Science

Hidden Symmetry Could Be Key To More Robust Quantum Systems, Researchers Find (phys.org) 14

An anonymous reader quotes a report from Phys.Org: Researchers have found a way to protect highly fragile quantum systems from noise, which could aid in the design and development of new quantum devices, such as ultra-powerful quantum computers. The researchers, from the University of Cambridge, have shown that microscopic particles can remain intrinsically linked, or entangled, over long distances even if there are random disruptions between them. Using the mathematics of quantum theory, they discovered a simple setup where entangled particles can be prepared and stabilized even in the presence of noise by taking advantage of a previously unknown symmetry in quantum systems.

Their results, reported in the journal Physical Review Letters, open a new window into the mysterious quantum world that could revolutionize future technology by preserving quantum effects in noisy environments, which is the single biggest hurdle for developing such technology. Harnessing this capability will be at the heart of ultrafast quantum computers. [...] Now, Dutta and his co-author Professor Nigel Cooper have discovered a robust quantum system where multiple pairs of qubits remain entangled even with a lot of noise. They modeled an atomic system in a lattice formation, where atoms strongly interact with each other, hopping from one site of the lattice to another. The authors found if noise were added in the middle of the lattice, it didn't affect entangled particles between left and right sides. This surprising feature results from a special type of symmetry that conserves the number of such entangled pairs.

They showed this hidden symmetry protects the entangled pairs and allows their number to be controlled from zero to a large maximum value. Similar conclusions can be applied to a broad class of physical systems and can be realized with already existing ingredients in experimental platforms, paving the way to controllable entanglement in a noisy environment. The researchers are hoping to confirm their theoretical findings with experiments within the next year.

Medicine

MDMA-Assisted Couples Therapy Investigated In Landmark Pilot Trial 68

A new study, published in the European Journal of Psychotraumatology, is the first to explore the effects of MDMA therapy in couples where one member is suffering from PTSD. New Atlas reports: This preliminary study investigated the feasibility of incorporating two MDMA sessions into a previously established PTSD therapeutic regime known as CBCT, or cognitive-behavioral conjoint therapy. As opposed to traditional PTSD therapies focusing on the individual, CBCT is designed to help improve relationship functioning for couples, while still improving PTSD symptoms in the individual patient. The new trial recruited six couples, in which one member of the couple had a pre-existing PTSD diagnosis, and explored the feasibility of incorporating two MDMA sessions into the CBCT protocol, which traditionally involves around 15 therapy sessions conducted over several months.

The new study reports the addition of MDMA to the couples therapy protocol resulted in effects that were, "on par with, or greater than, those achieved with CBCT alone." Improvements were detected in both relationship outcomes and individual PTSD symptoms. The effects were most significant at the six-month follow up implying the MDMA therapy confers compelling long-term benefits. It is important to note the study was uncontrolled, so any efficacy comparisons to CBCT alone can only be garnered by examining prior CBCT studies. However, this feasibility study does establish the addition of MDMA to the pre-existing therapeutic protocol is safe and it does not negatively interfere with other PTSD treatments.
Space

SpaceX's Successful Starship High-Altitude Flight Ends In a Fiery Explosion (engadget.com) 285

Thelasko shares a report from Engadget: After a successful launch, the Starship rose and successfully maneuvered its way to the landing area. However, it appeared that the spacecraft didn't slow down enough for a proper landing, and it exploded in thrilling fashion. On the live feed, SpaceX said the test was successful and noted it would be moving on to testing the SN9 prototype next. Elon Musk tweeted "Successful ascent, switchover to header tanks & precise flap control to landing point!" In a follow-up, he explained the landing, saying that low fuel header tank pressure during the landing burn contributed to the high touchdown velocity and the massive explosion. The good news, is that the team got âoeall the data we neededâ and it appears everything is in order for future tests. You can view the full test flight here.
Medicine

UK Warns People With Serious Allergies To Avoid Pfizer Vaccine (reuters.com) 175

Britain's medicine regulator warned people with significant allergies not to get Pfizer-BioNTech's COVID-19 vaccine after two people suffered adverse reactions, but was set to give more detailed guidance on Wednesday based on reviews of those cases. Reuters reports: Starting with the elderly and frontline workers, Britain began mass vaccinating its population on Tuesday, part of a global drive that poses one of the biggest logistical challenges in peacetime history. National Health Service medical director Stephen Powis said the advice had been changed as a precaution after two NHS workers reported anaphylactoid reactions from the vaccine. "Two people with a history of significant allergic reactions responded adversely yesterday," Powis said. "Both are recovering well."

The Medicines and Healthcare Products Regulatory Agency (MHRA) initially advised anyone with "a history of a significant allergic reaction to a vaccine, medicine or food" to avoid taking the vaccine. However, by the end of Wednesday that guidance was set to be refined after discussions with experts on the nature of the reactions. "We're tweaking advice to make it very clear that if you've got a food allergy, you're not more at risk," Imperial College London's Paul Turner, an expert in allergy and immunology who has been advising the MHRA on their revised guidance, told Reuters. Pfizer and BioNTech said they were supporting the MHRA's investigation.
In other vaccine-related news, the European Medicines Agency (EMA), the EU regulatory body in charge of approving COVID-19 vaccines, said today it was the victim of a cyberattack.
Medicine

EU Agency in Charge of COVID-19 Vaccine Approval Says it Was Hacked (zdnet.com) 40

The European Medicines Agency (EMA), the EU regulatory body in charge of approving COVID-19 vaccines, said today it was the victim of a cyber-attack. From a report: In a short two-paragraph statement posted on its website today, the agency discloses the security breach but said it couldn't disclose any details about the intrusion due to an ongoing investigation. EMA is currently in the process of reviewing applications for two COVID-19 vaccines, one from US pharma giant Moderna, and a second developed in a collaboration between BioNTech and Pfizer. An EMA spokesperson did not return a request for comment seeking information if the attack targeted its vaccine approval process or if it was a financially-motivated attack like ransomware. Nonetheless, in a follow-up statement released on its own website, BioNTech said that "some documents relating to the regulatory submission for Pfizer and BioNTech's COVID-19 vaccine candidate, BNT162b2, which has been stored on an EMA server, had been unlawfully accessed" during the attack, confirming that COVID-19 research was most likely the target of the attack.
Earth

Human 'Stuff' Now Outweighs All Life on Earth (sciencemag.org) 98

sciencehabit writes: It's not just your storage unit that's packed to the gills. According to a new study, the mass of all our stuff -- buildings, roads, cars, and everything else we manufacture -- now exceeds the weight of all living things on the planet. And the amount of new material added every week equals the total weight of Earth's nearly 8 billion people. "If you weren't convinced before that humans are dominating the planet, then you should be convinced now," says Timon McPhearson, an urban ecologist at the New School who was not involved with the research. "This is an eye-catching comparison," adds Fridolin Krausmann, a social ecologist at the University of Natural Resources and Life Sciences, Vienna, who also was not involved in the work. There are many measures of humanity's impact on the planet. Fossil fuels have sent greenhouse gases soaring to levels not seen in at least 800,000 years. Agriculture and dwellings have altered 70% of land. And humans have wiped out untold numbers of species in an emerging great extinction. The transformations are so great that researchers have declared we're living in a new human-dominated age: the Anthropocene.
Earth

Mount Everest, Earth's Tallest Mountain, Just Got Taller By About a Meter 44

China and Nepal say they have determined the "most accurate height of Everest that we have ever had," calculating it to be about 8,848.86 meters (29,031.7 feet) high. That's almost a meter taller than the mountain's previous recognized height. CNET reports: The two countries, which border each other at the mountain's summit, shared the news in a joint virtual briefing Tuesday that was streamed live online. Nepal began remeasuring the mountain in 2017, and China began its own work after Chinese President Xi Jinping visited Nepal in 2019. As part of the complicated measurement, researchers placed signal receivers on the mountain and measured the amount of time it took signals to travel between the receiver and satellites to figure out the new height. Global positioning devices and ground-penetrating radar were also used. Nepal's lead surveyor Khimlal Gautam ended up with damaged toes due to frostbite he suffered while installing the measuring equipment.

A 2015 earthquake in Nepal helped inspire the re-measurement of Everest. The BBC notes that some geologists thought that quake could've shrunk the mountain's snow cap, while others note that Himalayan peaks can actually grow taller over time as shifting tectonic plates push them upward.
Mars

Scientists Say They Have Come Up With a Potential Way To Make Oxygen On Mars (cnn.com) 122

An anonymous reader quotes a report from CNN: In a high-stakes mission that could take five years to complete, NASA wants to land astronauts on Mars in the 2030s. Transporting enough oxygen and fuel on a spacecraft to sustain the mission for anywhere near that length of time, however, isn't currently viable. The way NASA plans to address this problem is by deploying MOXIE, or the Mars Oxygen in Situ Resource Utilization Experiment. This system is in the testing phase on the Mars Perseverance rover, which launched in July. The apparatus will convert the carbon dioxide that makes up 96% of the gas in the red planet's' atmosphere into oxygen.

On Mars, oxygen is only 0.13% of the atmosphere, compared to 21% of the Earth's atmosphere. The MOXIE system essentially produces oxygen like a tree -- pulling in the Martian air with a pump and using an electrochemical process to separate two oxygen atoms from each molecule of carbon dioxide, or CO2. The experimental technique proposed by Vijay Ramani and his colleagues uses a completely different resource -- salty water in lakes beneath the Martian surface. "The presence of the brine is fortuitous because it lowers freezing point of the water. You take the salty, brackish water and electrolyze that. Our process takes the water and splits it into hydrogen and oxygen," Ramani said. The method proposed in the new paper, however, assumes that these brines are readily available on Mars, said Michael Hecht, NASA's principal investigator for MOXIE and associate director for research management at the Massachusetts Institute of Technology's Haystack Observatory.
The study has been published in the journal PNAS.
Medicine

Pfizer's Vaccine Offers Strong Protection After First Dose (nytimes.com) 190

The coronavirus vaccine made by Pfizer and BioNTech provides strong protection against Covid-19 within about 10 days of the first dose, according to documents published on Tuesday by the Food and Drug Administration before a meeting of its vaccine advisory group. From a report: The finding is one of several significant new results featured in the briefing materials, which include more than 100 pages of data analyses from the agency and from Pfizer. Last month, Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95 percent after two doses administered three weeks apart. The new analyses show that the protection starts kicking in far earlier. What's more, the vaccine worked well regardless of a volunteer's race, weight or age. While the trial did not find any serious adverse events caused by the vaccine, many participants did experience aches, fevers and other side effects. "This is what an A+ report card looks like for a vaccine," said Akiko Iwasaki, an immunologist at Yale University.

On Thursday, F.D.A.'s vaccine advisory panel will discuss these materials in advance of a vote on whether to recommend authorization of Pfizer and BioNTech's vaccine. Pfizer and BioNTech began a large-scale clinical trial in July, recruiting 44,000 people in the United States, Brazil and Argentina. Half of the volunteers got the vaccine, and half got the placebo. New coronavirus cases quickly tapered off in the vaccinated group of volunteers about 10 days after the first dose, according to one graph in the briefing materials. In the placebo group, cases kept steadily increasing.

Security

Did COVID Data Whistleblower Hack Florida's Emergency Alert System? Police Raid Home (miamiherald.com) 210

FriendlySolipsist writes: Independent journalist Rebekah Jones, a scientist fired by the Florida state government because, she said, of her refusal to manipulate official COVID-19 data releases to coincide with political considerations and who now operates website floridacovidaction.com, had her home raided by the FL state police who seized computers and cellphones, the Miami Herald reported. The FDLE affidavit in support of the raid was published by the Miami Herald and asserts that an unauthorized internal message was sent to the "ReadyOps" system within the state Department of Health from an IPv6 address associated with the Comcast account at Jones residence. "The Florida Department of Law Enforcement on Monday raided the home of a former Department of Health data analyst who has been running an alternative web site to the state's COVID dashboard, alleging that she may have broken into a state email system and sent an unauthorized message to employees," reports the Miami Herald. "But Rebekah Jones, who was was fired from her job in May as the geographic information system manager for DOH's Division of Disease Control and Health Protection and who has since filed a whistleblower complaint against the state, denied having any role in the alleged intrusion into the state web site and instead said she believes Monday's action was intended to silence her."

Slashdot reader mtrachtenberg shares a thread on Twitter of Jones describing what happened.
Sci-Fi

Aliens In Hiding Until Mankind Is Ready, Says Ex-Israeli Space Head (nypost.com) 332

The former head of Israel's space program, Haim Eshed, says space aliens have reached an agreement with the U.S. government to stay mum on the experiments they conduct on Earth -- as well as their secret base on Mars -- until mankind is ready to accept them. The New York Post reports: "The aliens have asked not to announce that they are here [because] humanity is not ready yet," Eshed told Israeli paper Yedioth Aharonoth, according to the Jewish Press. The Jewish Press -- speculating that Eshed, 87, may have gone to insanity and beyond -- goes on to unspool his tangled web, which claims the involvement of President Trump and interplanetary diplomacy.

"Trump was on the verge of revealing [aliens existence], but the aliens in the Galactic Federation are saying, "Wait, let people calm down first,'" Eshed, who helmed Israel's space security program from 1981 to 2010, reportedly said. "They don't want to start mass hysteria. They want to first make us sane and understanding." Until that day, aliens have secured an agreement to keep their moves under wraps, said Eshed, noting that the extraterrestrials come in peace.

"There's an agreement between the U.S. government and the aliens. They signed a contract with us to do experiments here. They, too, are researching and trying to understand the whole fabric of the universe, and they want us as helpers." One of the hubs of the cooperation is a base on Mars -- where, by the way, Eshed claims American astronauts have already set foot. "There's an underground base in the depths of Mars, where their representatives are, and also our American astronauts," Eshed reportedly said.
Eshed added: "If I had come up with what I'm saying today five years ago, I would have been hospitalized. Wherever I've gone with this in academia, they've said, 'The man has lost his mind,'" he reportedly said. "Today they're already talking differently. I have nothing to lose. I've received my degrees and awards, I am respected in universities abroad, where the trend is also changing."
Medicine

The World's First DNA 'Tricorder' In Your Pocket (phys.org) 54

Cold Spring Harbor Laboratory (CSHL) scientists developed the world's first mobile genome sequence analyzer, a new iPhone app called iGenomics. By pairing an iPhone with a handheld DNA sequencer, users can create a mobile genetics laboratory, reminiscent of the "tricorder" featured in Star Trek. Phys.Org reports: The iGenomics app runs entirely on the iOS device, reducing the need for laptops or large equipment in the field, which is useful for pandemic and ecology workers. Aspyn Palatnick programmed iGenomics in CSHL Adjunct Associate Professor Michael Schatz's laboratory, over a period of eight years, starting when he was a 14-year-old high school intern. The iPhone app was developed to complement the tiny DNA sequencing devices being made by Oxford Nanopore.

Users can AirDrop sequencing data to each other, enabling DNA analysis in the most remote locations -- even those without internet access. iGenomics may soon even find its way into the hands of astronauts, Schatz describes: "There's a lot of interest to do DNA sequencing in space. I'm trying to see if there's a way we can get iGenomics up there. There's a lot of people that are interested to do that. It's a real testament about how it would be impossible to do, you know, any sort of analysis on regular computers. It's just impossible to bring them with you." In the journal Gigascience, Palatnick and Schatz report the iGenomics algorithm can quickly map DNA sequences of viral pathogens, such as a flu virus or Zika virus, and identify mutations important for diagnosis and treatment. They also provide an online tutorial for analyzing other viral genomes, such as from a SARS-CoV-2 patient.

Medicine

California Partners With Apple and Google For COVID-19 Contact Tracing On Phones 61

California is partnering with Apple and Google on an app to let people use their phones to track potential exposure to COVID-19. CNET reports: The digital system uses Bluetooth signals from people's phones to alert them if they've been in contact with someone who's tested positive for the novel coronavirus. The project takes advantage of two of the world's most popular operating systems -- Apple's iOS and Google's Android -- to potentially reach billions of people. To use the features, people can download the app, called CA Notify, starting Thursday. On iPhones, people can turn on the alerts in their phone settings. The companies said they intend to shut down the tools after they are no longer needed to fight the pandemic.
Science

The Search for Dark Matter Is Dramatically Expanding (wired.com) 55

Ever since astronomers reached a consensus in the 1980s that most of the mass in the universe is invisible -- that "dark matter" must glue galaxies together and gravitationally sculpt the cosmos as a whole -- experimentalists have hunted for the nonluminous particles. From a report: They first set out in pursuit of a heavy, sluggish form of dark matter called a weakly interacting massive particle, or WIMP -- the early favorite candidate for the cosmos's missing matter because it could solve another, unrelated puzzle in particle physics. Over the decades, teams of physicists set up ever larger targets, in the form of huge crystals and multi-ton vats of exotic liquids, hoping to catch the rare jiggle of an atom when a WIMP banged into it. But these detectors have stayed quiet, and physicists are increasingly contemplating a broader spectrum of possibilities. On the heavy end, they say the universe's invisible matter could clump into black holes as heavy as stars. At the other extreme, dark matter could spread out in a fine mist of particles thousands of trillions of trillions of times lighter than electrons. With new hypotheses come new detection methods. Kathryn Zurek, a theoretical physicist at the California Institute of Technology, said that if current WIMP experiments don't see anything, "then I think there's going to be a substantial part of the field that's going to shift into these new kinds of experiments." Already, the work has begun.
United States

US Air Pollution Monitoring Network Falling Into Disrepair (reuters.com) 97

The U.S. air pollution monitoring network has fallen into disrepair after years of budget cuts and neglect, leaving tens of millions of Americans vulnerable to undetected bad air quality from events like wildfires to industrial pollution, according to a report by the investigative arm of Congress. Reuters: The conclusions from a 2-1/2-year audit by the U.S. Government Accountability Office (GAO) confirm key findings in a Reuters special report published last week that detailed broad failures in the air-pollution monitoring system, whose data guides U.S. regulatory policy and informs the public about health risks. Federal funding for the air monitoring network, which is overseen by the Environmental Protection Agency (EPA) and operated and maintained by state and local environmental agencies, has declined by about 20% since 2004, after adjusting for inflation, leaving it in poor condition, according to the GAO report viewed by Reuters. The GAO report said some agencies have reported termite damage and leaky roofs at shelters housing sensitive but aging pollution monitoring equipment, and one state agency resorted to shopping on eBay to find used monitor parts because the manufacturer had stopped making them.
Science

Missing Credit Card Payments May Be an Early Sign of Dementia, Study Says (cnn.com) 114

Patterns of missing credit card and loan payments could be an early indicator of dementia years before diagnosis, a new study says. From a report: The study, published Monday in the medical journal JAMA, looked at Medicare patients living alone across the United States and analyzed their credit data and payments over time. Researchers found that patients with Alzheimer's disease and related dementia were more likely to miss payments up to six years before getting diagnosed, the study said. And, those poor financial actions led them to subprime credit scores two and a half years before diagnosis, as opposed to the patients without dementia. "I think we were a little surprised that it was so common that we could really see it in the data," lead author Lauren Hersch Nicholas told CNN. "Doctors colloquially say that you should look for dementia in the checkbook, but I don't think we had any sense of for how many years in advance these effects could be happening." Nicholas is an associate professor at Johns Hopkins University. Researchers from Johns Hopkins and the Federal Reserve Board of Governors led the study. Alzheimer's dementia affects about 5.8 million Americans who are 65 and older, according to the Alzheimer's Association. The number of Americans with the disease is projected to hit 13.8 million by 2050, the non-profit said.
Space

Voyager Probes Detect New Kind of 'Electron Burst' in Interstellar Space (space.com) 24

"NASA's twin Voyager probes keep making discoveries in interstellar space," reports Space.com The Voyager mission has detected a new type of "electron burst," which will provide insights into the mechanisms of flaring stars, a new study reports. The bursts occur when cosmic ray electrons — fast-moving particles from far beyond the solar system — are pushed by shock waves generated by solar eruptions. The electrons then accelerate further along cosmic magnetic field lines to incredible speed, study team members said.

"The idea that shock waves accelerate particles is not new," corresponding author Don Gurnett, professor emeritus in physics and astronomy at the University of Iowa, said in a statement. "[But] we detected it in a new realm: the interstellar medium, which is much different than in the solar wind, where similar processes have been observed...."

Eventually, the magnetic field lines propel the cosmic rays to almost the speed of light — nearly 670 times faster than the solar shock waves that first pushed them. (The shock waves move at roughly 1 million mph, or 1.6 million kph, study team members said.)

The article marvels at the fact that the spacecraft are still sending back data regularly from 14 billion miles away, beyond the edge of our solar system, more than 43 years after they left earth. They even detected the original solar shock wave which caused the electron burst "up to a year after the event occurred.

"The wait time happened because the spacecraft are so far from the sun."
Medicine

Celebrating the Path-Breaking Research That Lead to Coronavirus Vaccines (adn.com) 134

The Washington Post tells the remarkable story of how both Moderna's vaccine and the Pfizer/BioNTech vaccine relied on a specially designed spike protein partially created by America's Vaccine Research Center — along with messenger RNA, "a technology never before harnessed in an approved vaccine."

And also decades of path-breaking research: If, as expected in the next few weeks, regulators give those vaccines the green light, the technology and the precision approach to vaccine design could turn out to be the pandemic's silver linings: scientific breakthroughs that could begin to change the trajectory of the virus this winter and also pave the way for highly effective vaccines and treatments for other diseases. Vaccine development typically takes years, even decades. The progress of the last 11 months shifts the paradigm for what's possible, creating a new model for vaccine development and a toolset for a world that will have to fight more never-before-seen viruses in years to come.

But the pandemic wasn't a sudden eureka moment — it was a catalyst that helped ignite lines of research that had been moving forward for years, far outside the spotlight of a global crisis... Long before the pandemic, [Vaccine Research Center deputy director Barney] Graham worked with colleagues there and in academia to create a particularly accurate 3-D version of the spiky proteins that protrude from the surface of coronaviruses — an innovation that was rejected for publication by scientific journals five times because reviewers questioned its relevance. His laboratory partnered with one of the companies, Moderna, working to develop a fast and flexible vaccine technology, in the hope that science would be ready to respond when a pandemic appeared. "People hear about [vaccine progress] and think someone just thought about it that night. The amount of work — it's really a beautiful story of fundamental basic research,", said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases [of which the center is an intramural division]...

The leading coronavirus vaccine candidates in the United States began their development not in January when a mysterious pneumonia emerged in Wuhan, China, but decades ago — with starts and stops along the way.... Unlike fields that were sparked by a single powerful insight, [Ugur Sahin, chief executive of BioNTech] said that the recent success of messenger RNA vaccines is a story of countless improvements that turned an alluring biological idea into a beneficial technology. "This is a field which benefited from hundreds of inventions," said Sahin, who noted that when he started BioNTech in 2008, he cautioned investors that the technology would not yield a product for at least a decade. He kept his word: Until the coronavirus sped things along, BioNTech projected the launch of its first commercial project in 2023...

On Jan. 13, Moderna RNA scientist Melissa Moore came into work and found her team already busy translating the stabilized spike protein into their platform. The company could start making the vaccine almost right away because of its experience manufacturing experimental cancer vaccines, which involves taking tumor samples and developing personalized vaccines in 45 days.

The Post tries to convey how meaningful this moment is for the scientists involved. Years ago one BioNTech scientist had told their spouse, "I just want to live long enough that I can help the RNA go to the patient. I want to see...at least one person would be helped with this treatment."

And when the Vaccine Research Center's deputy director finally learned how effective the Pfizer/BioNTech vaccine was, "I just let it all go.

"I was sobbing, I guess, is the term."
NASA

Component Failure Found in Crew Capsule NASA Hoped to Launch in 2021 (theverge.com) 146

The Verge reports that a power component failed on the Orion deep-space crew capsule that NASA hopes to launch (unmanned) from its Space Launch System (or SLS) in late 2021, in a mission called Artemis 1.

The problem? It's buried deep within one of the spacecraft's power/data units (or PDUs) within the adapter that connects the capsule to its power/propulsion trunk "service module," so there's no easy way to fix it: As many as nine months would be needed to take the vehicle apart and put it back together again, in addition to three months for subsequent testing, according to the presentation. Lockheed has another option, but it's never been done before and may carry extra risks, Lockheed Martin engineers acknowledge in their presentation. To do it, engineers would have to tunnel through the adapter's exterior by removing some of the outer panels of the adapter to get to the PDU. The panels weren't designed to be removed this way, but this scenario may only take up to four months to complete if engineers figure out a way to do it. A third option is that Lockheed Martin and NASA could fly the Orion capsule as is. The PDU failed in such a way that it lost redundancy within the unit, so it can still function. But at a risk-averse agency like NASA, flying a vehicle without a backup plan is not exactly an attractive option...

If engineers choose to remove Orion from its service module, the capsule's first flight on the SLS may be delayed past its current date of November 2021. But the SLS has experienced its own set of delays: it was supposed to fly for the first time in 2017 but hasn't done so yet. It's not clear if the SLS itself will make the November 2021 flight date either; a key test of the rocket coming up at the end of the year has been pushed back, with no new target date set. So it's possible that Lockheed Martin and NASA can fix Orion before the SLS is ready to fly.

Any further delays to Artemis I add uncertainty to NASA's lunar landing timeline. NASA is hoping to land astronauts on the Moon by 2024, though many experts are skeptical that such a mission can be pulled off in time. Artemis I is vulnerable to other possible delays, but the component failure adds one more level of uncertainty to when the Orion and SLS combo will get off the ground.

Biotech

New Research Shows What We Can Accomplish by Manipulating Biology (arstechnica.com) 24

Long-time Slashdot reader sixoh1 shares "an interesting spin on biotechnology tools that we've been seeing explode lately like Crisper-CAS and mRNA."

Ars Technica writes: This is in no way a route to a practical therapy, but it does provide a fantastic window into what we can accomplish by manipulating biology. The whole effort described in the new paper is focused on a simple idea: if you figure out how to wreck one of the virus's key proteins, it won't be able to infect anything. And, conveniently, our cells have a system for destroying proteins, since that's often a useful thing to do...

This system relies on a small protein called "ubiquitin." When a protein is to be targeted for destruction, enzymes called ubiquitin ligases chemically link a chain of ubiquitins to it. These serve as a tag that is recognized by enzymes that digest any proteins with ubiquitin attached to them. So, the idea behind the new work is to identify a key viral protein and figure out how to attach ubiquitin to it...

Unfortunately, there are no proteins that attach ubiquitin to the viral spike protein. Or, rather, there were no proteins that fit that description. But a team at Harvard has now produced one.

They fed atomic-level details of the proteins' structure into software that finds the most energetically-favored interactions between proteins, simulated mutations, and eventually engineered the most promising ones to test their efficacy, ultimately cutting the presence of the viral spike protein in tested cells by 60 percent.

Ars Technica ultimately calls it "A mildly insane idea for disabling the coronavirus," though "Unfortunately, it's also likely to be absolutely useless... this is likely to be a non-starter, especially given that there are promising vaccines and many other potential therapies ahead of it in the pipeline for safety testing."

Yet "while the details of this work aren't really significant, the fact that we've developed all the underlying technology needed for it is worth keeping in mind."

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