DNA origami involves using short DNA strands to hold a longer, folded strand in place at certain points, like sticky tape. Until now, assembling the shape has involved heating the DNA and allowing it to cool slowly for up to a week. But researchers at the Technical University of Munich in Germany have worked out that for most of the cooling period, nothing happens. But when a crucial temperature is reached, the whole structure forms suddenly (abstract).
The researchers now aim to design nanostructures with optimal folding temperatures close to 37 C, the temperature at which mammalian cell cultures are grown, so that DNA machines could one day be used in biological settings."