Medicine

Researchers Finally Link Long Covid 'Brain Fog' to Inflammation (thehill.com) 111

An anonymous reader shared this report from The Hill: A new study indicates the debilitating "brain fog" suffered by millions of long COVID patients is linked to changes in the brain, including inflammation and an impaired ability to rewire itself following COVID-19 infection. United Press International reported this week that the small-scale study, conducted by researchers at Corewell Health in Grand Rapids, Michigan, and Michigan State University, shows that altered levels of a pair of key brain chemicals could be the culprit.

The study marks the first time doctors have been able to provide scientific proof that validates the experiences of the approximately 12 million COVID "long-haulers" in the U.S. who have reported neurological symptoms. Researchers looked at biomarkers in study participants and found that those complaining of brain fog had higher levels of an anti-inflammatory protein that is crucial to regulating a person's immune system, UPI reported. They also showed lower serum levels of nerve growth factor, a protein vital to the brain's plasticity...

One of the biggest issues involving long COVID has been doctors' inability to find physical proof of the symptoms described by patients. The study has changed that, according to co-author Dr. Bengt Arnetz.

Earth

The Most Promising Ways to Destroy 'Forever Chemicals' (msn.com) 85

"Researchers are seeking a breakthrough in technologies to tackle PFAS contamination," reports the Washington Post — including experiments with ultraviolet light, plasma and sound waves: "We're in a good spot," said Christopher Higgins, a professor of civil and environmental engineering at the Colorado School of Mines who researches PFAS. "There's a lot of things being tested. ... Around the world, everyone is trying to work on this topic...." PFAS destruction technologies are beginning to show potential. Some methods have been licensed by companies that are rolling out the systems in real-world settings. "There's been a lot of research happening over the past few years looking at advanced destruction technologies, and there's been a lot of improvements and advancements, and we're now starting to see some of them actually at scale," said Anna Reade [a senior scientist and director of PFAS advocacy at the Natural Resources Defense Council].

An approach known as supercritical water oxidation is one of the more developed technologies, Reade and other experts said. It involves heating and pressurizing water to a specific point that creates the ideal conditions to break every carbon fluorine bond, said Amy Dindal [a PFAS expert with Battelle, a science and technology nonprofit that has developed a PFAS destruction technology]. The process used in a patented technology created by Battelle produces carbon dioxide and a form of fluorine that can be quickly neutralized to become a harmless salt. "It's a complete destruction and mineralization technology, because we're actually breaking all of the carbon fluorine bonds," Dindal said, adding that the technology is "PFAS agnostic...."

Another promising approach using heat and pressure was developed by researchers at the Colorado School of Mines [and already licensed by a company in Washington]. Known as hydrothermal alkaline treatment, or HALT, it involves adding a low-cost chemical reagent such as sodium hydroxide to superheated liquid water.... A destruction method that harnesses ultraviolet light has also emerged as a contender [has licensed by a company in Michigan]. When UV light oxidizes an electron-generating compound, it produces a powerful electron that's very reactive and strong enough to break carbon fluorine bonds... Other technologies are experimenting with the use of plasma, which can generate reactive electrons to break down PFAS but tends to require a large amount of energy. Researchers are also experimenting with a process that uses sound waves. High-intensity sound waves create small bubbles in a water system or liquid waste stream, Higgins said. As those bubbles collapse, they can generate the high temperatures and pressure needed to degrade PFAS.

But "At the end of the day, not using these chemicals unless it's absolutely necessary is the actually most effective tool in our toolbox," Reade said.
Science

Paleontologists Identify Tiny Three-Eyed 'Sea Moth' Predator in Fossils (ground.news) 8

"With the help of more than five dozen fossils, paleontologists have uncovered a tiny three-eyed predator nicknamed the 'sea moth'," reports CNN, "that swam in Earth's oceans 506 million years ago."

Tiny as in 15 to 61 mm in total body length. (That's 0.60 to 2.4 inches...) But check out the illustration in CNN's article... Mosura fentoni, as the species is known, belongs to a group called radiodonts, an early offshoot of the arthropod evolutionary tree, according to a new study published Tuesday in the journal Royal Society Open Science. While radiodonts are now extinct, studying their fossilized remains can illuminate how modern arthropods such as insects, spiders and crabs evolved. One of the most diverse animal groups, arthropods are believed to account for more than 80% of living animal species, said lead study author Dr. Joe Moysiuk, curator of paleontology and geology at the Manitoba Museum in Winnipeg.

Well-preserved specimens of the previously unknown Mosura fentoni also reveal something that's never been seen in any other radiodont: an abdomen-like body region with 16 segments that include gills at its rear. This part of the creature's anatomy is similar to a batch of segments bearing respiratory organs at the rear of the body found in distant modern radiodont relatives like horseshoe crabs, woodlice and insects, Moysiuk said.... No animal living today quite looks like Mosura fentoni, Moysiuk said, although it had jointed claws similar to those of modern insects and crustaceans. But unlike those critters, which can have two or four additional eyes used to help maintain orientation, Mosura had a larger and more conspicuous third eye in the middle of its head.

"Although not closely related, Mosura probably swam in a similar way to a ray, undulating its multiple sets of swimming flaps up and down, like flying underwater," Moysiuk said in an email. "It also had a mouth shaped like a pencil sharpener and lined with rows of serrated plates, unlike any living animal." About the size of an adult human's index finger, Mosura and its swimming flaps vaguely resemble a moth, which led researchers to call it the "sea moth."

The Royal Society publication notes the etymology of the species name (Mosura fentoni is "from the name of the fictional Japanese monster, or kaiju... also known as 'Mothra'...in reference to the moth-like appearance of the animal."

Thanks to long-time Slashdot reader walterbyrd for sharing the news.
Australia

The Top Fell Off Australia's First Orbital-Class Rocket, Delaying Its Launch (arstechnica.com) 24

Australia's first orbital-class rocket launch was delayed after the nose cone of Gilmour Space's Eris rocket unexpectedly detached due to an electrical fault during final preparations. Although no damage occurred and no payload was onboard, the company is postponing the launch to investigate and replace the fairing before attempting another test flight. Ars Technica reports: Gilmour, the Australian startup that developed the Eris rocket, announced the setback in a post to the company's social media accounts Thursday. "During final launch preparations last night, an electrical fault triggered the system that opens the rocket's nose cone (the payload fairing)," Gilmour posted on LinkedIn. "This happened before any fuel was loaded into the vehicle. Most importantly, no one was injured, and early checks show no damage to the rocket or the launch pad."

Gilmour was gearing up for a launch attempt from a privately owned spaceport in the Australian state of Queensland early Friday, local time (Thursday in the United States). The company's Eris rocket, which was poised for its first test flight, stands about 82 feet (25 meters) tall with its payload fairing intact. It's designed to haul a payload of about 670 pounds (305 kilograms) to low-Earth orbit.

While Gilmour didn't release any photos of the accident, a company spokesperson confirmed to Ars that the payload fairing "deployed" after the unexpected electrical issue triggered the separation system. Payload fairings are like clamshells that enclose the satellites mounted to the top of their launch vehicle, protecting them from weather on the launch pad and from airflow as the rocket accelerates to supersonic speeds. Once in space, the rocket releases the payload shroud, usually in two halves. There were no satellites aboard the rocket as Gilmour prepared for its first test flight.
The report notes that the Eris rocket is aiming to "become the first all-Australian launcher to reach orbit."
Communications

NASA Resurrects Voyager 1 Interstellar Spacecraft's Thrusters After 20 Years (space.com) 64

NASA engineers have successfully revived Voyager 1's backup thrusters, unused since 2004 and once considered defunct. Space.com reports: This remarkable feat became necessary because the spacecraft's primary thrusters, which control its orientation, have been degrading due to residue buildup. If its thrusters fail completely, Voyager 1 could lose its ability to point its antenna toward Earth, therefore cutting off communication with Earth after nearly 50 years of operation. To make matters more urgent, the team faced a strict deadline while trying to remedy the thruster situation. After May 4, the Earth-based antenna that sends commands to Voyager 1 -- and its twin, Voyager 2 -- was scheduled to go offline for months of upgrades. This would have made timely intervention impossible.

To solve the problem, NASA's team had to reactivate Voyager 1's long-dormant backup roll thrusters and then attempt to restart the heaters that keep them operational. If the star tracker drifted too far from its guide star during this process, the roll thrusters would automatically fire as a safety measure -- but if the heaters weren't back online by then, firing the thrusters could cause a dangerous pressure spike. So, the team had to precisely realign the star tracker before the thrusters engaged. Because Voyager is so incredibly distant, the team faced an agonizing 23-hour wait for the radio signal to travel all the way back to Earth. If the test had failed, Voyager might have already been in serious trouble. Then, on March 20, their patience was finally rewarded when Voyager responded perfectly to their commands. Within 20 minutes of receiving the signal, the team saw the thruster heaters' temperature soar -- a clear sign that the backup thrusters were firing as planned.
"It was such a glorious moment. Team morale was very high that day," Todd Barber, the mission's propulsion lead at JPL, said in the statement. "These thrusters were considered dead. And that was a legitimate conclusion. It's just that one of our engineers had this insight that maybe there was this other possible cause, and it was fixable. It was yet another miracle save for Voyager."
Medicine

FDA Clears First Blood Test To Help Diagnose Alzheimer's Disease 48

An anonymous reader quotes a report from the Associated Press: U.S. health officials on Friday endorsed the first blood test that can help diagnose Alzheimer's and identify patients who may benefit from drugs that can modestly slow the memory-destroying disease. The test can aid doctors in determining whether a patient's memory problems are due to Alzheimer's or a number of other medical conditions that can cause cognitive difficulties. The Food and Drug Administration cleared it for patients 55 and older who are showing early signs of the disease.

The new test, from Fujirebio Diagnostics, Inc., identifies a sticky brain plaque, known as beta-amyloid, that is a key marker for Alzheimer's. Previously, the only FDA-approved methods for detecting amyloid were invasive tests of spinal fluid or expensive PET scans. The lower costs and convenience of a blood test could also help expand use of two new drugs, Leqembi and Kisunla, which have been shown to slightly slow the progression of Alzheimer's by clearing amyloid from the brain. Doctors are required to test patients for the plaque before prescribing the drugs, which require regular IV infusions. [...]

A number of specialty hospitals and laboratories have already developed their own in-house tests for amyloid in recent years. But those tests aren't reviewed by the FDA and generally aren't covered by insurance. Doctors have also had little data to judge which tests are reliable and accurate, leading to an unregulated marketplace that some have called a "wild west." Several larger diagnostic and drug companies are also developing their own tests for FDA approval, including Roche, Eli Lilly and C2N Diagnostics. The tests can only be ordered by a doctor and aren't intended for people who don't yet have any symptoms.
AI

MIT Asks arXiv To Take Down Preprint Paper On AI and Scientific Discovery 19

MIT has formally requested the withdrawal of a preprint paper on AI and scientific discovery due to serious concerns about the integrity and validity of its data and findings. It didn't provide specific details on what it believes is wrong with the paper. From a post: "Earlier this year, the COD conducted a confidential internal review based upon allegations it received regarding certain aspects of this paper. While student privacy laws and MIT policy prohibit the disclosure of the outcome of this review, we are writing to inform you that MIT has no confidence in the provenance, reliability or validity of the data and has no confidence in the veracity of the research contained in the paper. Based upon this finding, we also believe that the inclusion of this paper in arXiv may violate arXiv's Code of Conduct.

"Our understanding is that only authors of papers appearing on arXiv can submit withdrawal requests. We have directed the author to submit such a request, but to date, the author has not done so. Therefore, in an effort to clarify the research record, MIT respectfully request that the paper be marked as withdrawn from arXiv as soon as possible." Preprints, by definition, have not yet undergone peer review. MIT took this step in light of the publication's prominence in the research conversation and because it was a formal step it could take to mitigate the effects of misconduct. The author is no longer at MIT. [...]

"We are making this information public because we are concerned that, even in its non-published form, the paper is having an impact on discussions and projections about the effects of AI on science. Ensuring an accurate research record is important to MIT. We therefore would like to set the record straight and share our view that at this point the findings reported in this paper should not be relied on in academic or public discussions of these topics."
The paper in question, titled "Artificial Intelligence, Scientific Discovery, and Product Innovation" and authored by Aidan Toner-Rodgers, investigated the effects of introducing an AI-driven materials discovery tool to 1,018 scientists in a U.S. R&D lab. The study reported that AI-assisted researchers discovered 44% more materials, filed 39% more patents, and achieved a 17% increase in product innovation. These gains were primarily attributed to AI automating 57% of idea-generation tasks, allowing top-performing scientists to focus on evaluating AI-generated suggestions effectively. However, the benefits were unevenly distributed; lower-performing scientists saw minimal improvements, and 82% of participants reported decreased job satisfaction due to reduced creativity and skill utilization.

The Wall Street Journal reported on MIT's statement.
Medicine

Covid-19 Spikes in Hong Kong, Singapore as New Wave Spreads (bloomberg.com) 96

Health authorities in densely-populated Hong Kong and Singapore have warned that Covid-19 cases are spiking, as a resurgent wave spreads through Asia. Bloomberg: The virus' activity in Hong Kong is now "quite high," Albert Au, head of the Communicable Disease Branch of the city's Center for Health Protection, told local media this week. The percentage of respiratory samples testing Covid-positive in Hong Kong recently reached its highest in a year.

Severe cases -- including deaths -- also reached its highest level in about a year to 31 in the week through May 3, the center's data shows. While the resurgence is yet to match the infection peaks seen in the past two years, rising viral load found in sewage water and Covid-related medical consultations and hospitalizations suggest the virus is actively spreading in the city of over 7 million people.

Rival financial hub Singapore is also on Covid alert. The city-state's health ministry released its first update on infection numbers in almost a year this month, as the estimated number of cases jumped 28% to 14,200 in the week through May 3 from the previous seven days while daily hospitalization rose around 30%. Singapore now only provides case updates when there is a noticeable spike.

United States

MIT Says It No Longer Stands Behind Student's AI Research Paper (msn.com) 28

MIT said Friday it can no longer stand behind a widely circulated paper on AI written by a doctoral student in its economics program. The paper said that the introduction of an AI tool in a materials-science lab led to gains in new discoveries, but had more ambiguous effects on the scientists who used it. WSJ: MIT didn't name the student in its statement Friday, but it did name the paper. That paper, by Aidan Toner-Rodgers, was covered by The Wall Street Journal and other media outlets. In a press release, MIT said it "has no confidence in the provenance, reliability or validity of the data and has no confidence in the veracity of the research contained in the paper."

The university said the author of the paper is no longer at MIT. The paper said that after an AI tool was implemented at a large materials-science lab, researchers discovered significantly more materials -- a result that suggested that, in certain settings, AI could substantially improve worker productivity. But it also showed that most of the productivity gains went to scientists who were already highly effective, and that overall the AI tool made scientists less happy about their work.

China

China Launches First of 2,800 Satellites For AI Space Computing Constellation (spacenews.com) 71

China launched 12 satellites on Wednesday as part of the âoeThree-Body Computing Constellation,â the worldâ(TM)s first dedicated orbital computing network led by ADA Space and Zhejiang Lab. SpaceNews reports: A Long March 2D rocket lifted off at 12:12 a.m. Eastern (0412 UTC) May 14 from Jiuquan Satellite Launch Center in northwest China. Insulation tiles fell away from the payload fairing as the rocket climbed into a clear blue sky above the spaceport. The China Aerospace Science and Technology Corporation (CASC) announced a fully successful launch, revealing the mission to have sent 12 satellites for a space computing constellation into orbit. Commercial company ADA Space released further details, stating that the 12 satellites form the "Three-Body Computing Constellation," which will directly process data in space, rather than on the ground, reducing reliance on ground-based computing infrastructure. The constellation will be capable of a combined 5 peta operations per second (POPS) with 30 terabytes of onboard storage.

The satellites feature advanced AI capabilities, up to 100 Gbps laser inter-satellite links and remote sensing payloads -- data from which will be processed onboard, reducing data transmission requirements. One satellite also carries a cosmic X-ray polarimeter developed by Guangxi University and the National Astronomical Observatories of the Chinese Academy of Sciences (NAOC), which will detect, identify and classify transient events such as gamma-ray bursts, while also triggering messages to enable followup observations by other missions. [...] The company says the constellation can meet the growing demand for real-time computing in space, as well as help China take the lead globally in building space computing infrastructure, seize the commanding heights of this future industry. The development could mark the beginning of space-based cloud computing as a new capability, as well as open a new arena for strategic competition with the U.S.
You can watch a recording of the launch here.
Space

Dark Matter Formed When Fast Particles Slowed Down and Got Heavy, New Theory Says (phys.org) 38

Dartmouth researchers propose that dark matter originated from massless, light-like particles in the early universe that rapidly condensed into massive particles through a spin-based interaction. Phys.Org reports: [T]he study authors write that their theory is distinct because it can be tested using existing observational data. The extremely low-energy particles they suggest make up dark matter would have a unique signature on the cosmic microwave background, or CMB, the leftover radiation from the Big Bang that fills all of the universe. "Dark matter started its life as near-massless relativistic particles, almost like light," says Robert Caldwell, a professor of physics and astronomy and the paper's senior author. "That's totally antithetical to what dark matter is thought to be -- it is cold lumps that give galaxies their mass," Caldwell says. "Our theory tries to explain how it went from being light to being lumps."

Hot, fast-moving particles dominated the cosmos after the burst of energy known as the Big Bang that scientists believe triggered the universe's expansion 13.7 billion years ago. These particles were similar to photons, the massless particles that are the basic energy, or quanta, of light. It was in this chaos that extremely large numbers of these particles bonded to each other, according to Caldwell and Guanming Liang, the study's first author and a Dartmouth senior. They theorize that these massless particles were pulled together by the opposing directions of their spin, like the attraction between the north and south poles of magnets. As the particles cooled, Caldwell and Liang say, an imbalance in the particles' spins caused their energy to plummet, like steam rapidly cooling into water. The outcome was the cold, heavy particles that scientists think constitute dark matter.
The findings have been published in the journal Physical Review Letters.
Science

Baby Is Healed With World's First Personalized Gene-Editing Treatment (nytimes.com) 53

Scientists have successfully treated a 9.5-month-old boy with an ultra-rare genetic disorder using the world's first personalized gene-editing therapy. The patient, identified as KJ, has CPS1 deficiency -- a condition affecting just one in 1.3 million babies that prevents proper ammonia processing and is often fatal.

The breakthrough treatment, detailed in the New England Journal of Medicine, uses base editing technology to correct KJ's specific DNA mutation. The therapy delivers CRISPR components wrapped in fatty lipid molecules that protect them in the bloodstream until they reach liver cells, where they make the precise edit needed.

After three infusions, KJ now eats normal amounts of protein and has maintained stable ammonia levels even through viral illnesses that would typically cause dangerous spikes. His weight has increased from the 7th to 40th percentile. Dr. Peter Marks, former FDA official, called the approach "one of the most potentially transformational technologies" because it could be rapidly adapted for thousands of other rare genetic diseases without lengthy development cycles.
Medicine

First US Hub For Experimental Medical Treatments Is Coming (technologyreview.com) 40

Montana has passed a bill allowing licensed clinics to offer experimental medical treatments that haven't been approved by the FDA, provided the drugs have passed phase I safety trials. MIT Technology Review reports: The bill, which was passed by the state legislature on April 29 and is expected to be signed by Governor Greg Gianforte, essentially expands on existing Right to Try legislation in the state. But while that law was originally designed to allow terminally ill people to access experimental drugs, the new bill was drafted and lobbied for by people interested in extending human lifespans -- a group of longevity enthusiasts that includes scientists, libertarians, and influencers. These longevity enthusiasts are hoping Montana will serve as a test bed for opening up access to experimental drugs. [...]

Supporters of the bill say it gives individuals the freedom to make choices about their own bodies. At the same event, bioethicist Jessica Flanigan of the University of Richmond said she was "optimistic" about the measure, because "it's great any time anybody is trying to give people back their medical autonomy." Ultimately, they hope that the new law will enable people to try unproven drugs that might help them live longer, make it easier for Americans to try experimental treatments without having to travel abroad, and potentially turn Montana into a medical tourism hub.

But ethicists and legal scholars aren't as optimistic. "I hate it," bioethicist Alison Bateman-House of New York University says of the bill. She and others are worried about the ethics of promoting and selling unproven treatments -- and the risks of harm should something go wrong. [...] At any rate, the clinics are coming to Montana, says [Dylan Livingston, founder and CEO of the Alliance for Longevity Initiatives]. "We have half a dozen that are interested, and maybe two or three that are definitively going to set up shop out there." He won't name names, but he says some of the interested clinicians already have clinics in the US, while others are abroad."

Mac Davis -- founder and CEO of Minicircle, the company that developed the controversial "anti-aging" gene therapy -- told MIT Technology Review he was "looking into it." "I think this can be an opportunity for America and Montana to really kind of corner the market when it comes to medical tourism," says Livingston. "There is no other place in the world with this sort of regulatory environment."

Science

InventWood Is About To Mass-Produce Wood That's Stronger Than Steel (techcrunch.com) 99

Longtime Slashdot reader ndsurvivor shares a report from TechCrunch: In 2018, Liangbing Hu, a materials scientist at the University of Maryland, devised a way to turn ordinary wood into a material stronger than steel. It seemed like yet another headline-grabbing discovery that wouldn't make it out of the lab. "All these people came to him," said Alex Lau, CEO of InventWood, "He's like, OK, this is amazing, but I'm a university professor. I don't know quite what to do about it."

Rather than give up, Hu spent the next few years refining the technology, reducing the time it took to make the material from more than a week to a few hours. Soon, it was ready to commercialize, and he licensed the technology to InventWood. Now, the startup's first batches of Superwood will be produced starting this summer. "Right now, coming out of this first-of-a-kind commercial plant -- so it's a smaller plant -- we're focused on skin applications," Lau said. "Eventually we want to get to the bones of the building. Ninety percent of the carbon impact from buildings is concrete and steel in the construction of the building." To build the factory, InventWood has raised $15 million in the first close of a Series A round. The round was led by the Grantham Foundation with participation from Baruch Future Ventures, Builders Vision, and Muus Climate Partners, the company exclusively told TechCrunch.
How do they do it? According to TechCrunch, InventWood's Superwood is made by treating regular timber with "food industry" chemicals to remove lignin and modify its structure, then compressing it to increase hydrogen bonding between cellulose fibers. This densification makes the wood up to 10 times stronger than natural wood, with a higher strength-to-weight ratio than steel. "You end up with something that looks like these richer, tropical hardwoods," Lau added.
Robotics

Student's Robot Obliterates 4x4 Rubik's Cube World Record (bbc.com) 26

An anonymous reader quotes a report from the BBC: A student's robot has beaten the world record for solving a four-by-four Rubik's cube -- by 33 seconds. Matthew Pidden, a 22-year-old University of Bristol student, built and trained the "Revenger" over 15 weeks for his computer science bachelor's degree. The robot solved the cube in 45.305 seconds, obliterating the world record of 1 minute 18 seconds. However, the human record for solving the cube is 15.71 seconds.

Mr Pidden's robot uses dual webcams to scan the cube, a custom mechanism to manipulate the faces, and a fully self-built solving algorithm to generate efficient solutions. The student now plans to study for a master's degree in robotics at Imperial College London.

Science

Universe Expected To Decay Much Sooner Than Previously Thought (phys.org) 124

Dutch researchers have recalculated the timeline for cosmic decay via Hawking-like radiation and found that the universe may end much sooner than previously thought -- around 10^78 years, rather than 10^1100. Phys.Org reports: The research by black hole expert Heino Falcke, quantum physicist Michael Wondrak, and mathematician Walter van Suijlekom (all from Radboud University, Nijmegen, the Netherlands) is a follow-up to a 2023 paper by the same trio. In that paper, they showed that not only black holes, but also other objects such as neutron stars, can "evaporate" via a process akin to Hawking radiation. After that publication, the researchers received many questions from inside and outside the scientific community about how long the process would take. They have now answered this question in the new article.

The researchers calculated that the end of the universe is about 10^78 years away, if only Hawking-like radiation is taken into account. This is the time it takes for white dwarf stars, the most persistent celestial bodies, to decay via Hawking-like radiation. Previous studies, which did not take this effect into account, put the lifetime of white dwarfs at 10^1100 years. Lead author Heino Falcke said, "So the ultimate end of the universe comes much sooner than expected, but fortunately it still takes a very long time."
The findings have been published in the Journal of Cosmology and Astroparticle Physics.
Mars

Is There Water on Mars? (theconversation.com) 37

Evidence is mounting for "a vast reservoir of liquid water" on Mars, according to a new article by Australian National University professor Hrvoje TkalÄiÄ and geophysics associate professor Weijia Sun from the Chinese Academy of Geological Sciences, announcing their recently published paper.

"Using seismic data from NASA's InSight mission, we uncovered evidence that the seismic waves slow down in a layer between 5.4 and 8 kilometres below the surface, which could be because of the presence of liquid water at these depths." Mars is covered in traces of ancient bodies of water. But the puzzle of exactly where it all went when the planet turned cold and dry has long intrigued scientists... Billions of years ago, during the Noachian and Hesperian periods (4.1 billion to 3 billion years ago), rivers carved valleys and lakes shimmered. As Mars' magnetic field faded and its atmosphere thinned, most surface water vanished. Some escaped to space, some froze in polar caps, and some was trapped in minerals, where it remains today. But evaporation, freezing and rocks can't quite account for all the water that must have covered Mars in the distant past.

Calculations suggest the "missing" water is enough to cover the planet in an ocean at least 700 metres deep, and perhaps up to 900 metres deep. One hypothesis has been that the missing water seeped into the crust. Mars was heavily bombarded by meteorites during the Noachian period, which may have formed fractures that channelled water underground. Deep beneath the surface, warmer temperatures would keep the water in a liquid state — unlike the frozen layers nearer the surface.

In 2018, NASA's InSight lander touched down on Mars to listen to the planet's interior with a super-sensitive seismometer. By studying a particular kind of vibration called "shear waves", we found a significant underground anomaly: a layer between 5.4 and 8 kilometres down where these vibrations move more slowly. This "low-velocity layer" is most likely highly porous rock filled with liquid water, like a saturated sponge. Something like Earth's aquifers, where groundwater seeps into rock pores. We calculated the "aquifer layer" on Mars could hold enough water to cover the planet in a global ocean 520-780m deep.

InSight's seismometer captured vibrations between the crust of Mars and its lower layers from two meteorite impacts in 2021 and a Marsquake in 2022. "These signatures let us pinpoint boundaries where rock changes, revealing the water-soaked layer 5.4 to 8 kilometres deep."

It's an exciting possibility. "Purified, it could provide drinking water, oxygen, or fuel for rockets." And since microbes thrives on earth in deep rocks filled with water, "Could similar life, perhaps relics of ancient Martian ecosystems, persist in these reservoirs?"
Space

How Spaceport America Will Grow (space.com) 12

18 years ago Slashdot covered the creation of Spaceport America.

Today Space.com hails it as "the first purpose-built commercial spaceport in the world." But engineer/executive director Scott McLaughlin has plans to grow even more. Already home to an array of commercial space industry tenants, such as Virgin Galactic, SpinLaunch, Up Aerospace, and Prismatic, Spaceport America is a "rocket-friendly environment of 6,000 square miles of restricted airspace, low population density, a 12,000-foot by 200-foot runway, vertical launch complexes, and about 340 days of sunshine and low humidity," the organization boasts on its website...

Space.com: What changes do you see that make Spaceport America even more viable today?

McLaughlin: I think opening ourselves up to doing different kinds of work. We're more like a civilian test range now. We've got high-altitude UAVs [Unmanned Aerial Vehicles]. We're willing to do engine production. We believe we're about to sign a data center, one that's able to provide services to our customers who want low-latency, artificial intelligence, or high-powered computing. You'll be able to rent some virtual machines and do your own thing and have it be instantaneous at the spaceport. So I think being more broadminded about what we can do at the spaceport is helping generate customers and revenue...

Our goal is to see Virgin Galactic fly in a year or so, hopefully flying twice a week, and that will have a big impact on the spaceport... [W]e're trying to be open-minded as we're partnered with White Sands Missile Range to use that airspace. We're even looking at things like an electromagnetic pulse facility. It's a customer that I can't identify yet... We are working on a "reentry" license too. We recently discussed this with specialists and we think we have a site relatively close to the spaceport that's flat and free of mesquite bushes and such, so we can do capsule return and other types of return. And of course we have the runway. So I'd think we'd be the only spaceport that does vertical and horizontal launch and reentry....

We're never going to have the throughput that the Cape in Florida has. But we'll be a good alternative especially if you're going to do a small to medium-sized launch, and you need to do it quickly, and perhaps do it more securely than you would if you were to fly over water. That's why the Department of Defense is showing interest in the inland spaceport.

Medicine

Theranos Fraudster's Partner Launches His Own Blood-Testing Startup (thedailybeast.com) 34

"The romantic partner of Theranos fraudster Elizabeth Holmes has launched a start-up that sounds eerily similar to the venture that landed his girlfriend behind bars," writes The Daily Beast.

He's incorporated "Haemanthus" in Delaware a year and a half ago (though the company operates out of his neighborhood in Austin), according to the New York Times. Haemanthus appears to have around 10 employees.

From The Daily Beast: California hotel heir Billy Evans' new company is a blood-testing firm that markets itself as "the future of diagnostics," offering "a radically new approach to health testing," according to The New York Times. In other words, exactly what Theranos said it would do. Holmes is even advising the start-up from the Texas prison where she is serving out an 11-year prison sentence for fraud, sources told NPR... Evans has managed to raise nearly $20 million in funds from both friends and established investors in Austin and San Francisco, according to the investor materials.
The Times reports that Evan's company "plans to begin with testing pets for diseases before progressing to humans, according to two investors pitched on the company."

And TechCrunch reminds readers that Elizabeth Holmes said in a recent interview "that she remains 'completely committed to my dream of making affordable healthcare solutions available to everyone.'"
Biotech

Court Unanimously Denies Theranos Founder Elizabeth Holmes' Request For Rehearing (cnbc.com) 60

Elizabeth Holmes has lost her bid to have the appeal of her 2022 fraud conviction reheard by the 9th Circuit Court of Appeals, leaving the U.S. Supreme Court as her final option. She and former Theranos executive Sunny Balwani remain liable for $452 million in restitution, while Holmes continues serving her 11-year sentence. CNBC reports: The 9th Circuit U.S. Court of Appeals denied Holmes' request for a rehearing before the original three-judge panel that upheld her conviction. At the same time, the court said no judge on the circuit court had asked for a vote on whether to have the full court rehear the appeal.

Holmes, 41, was sentenced in January 2023 to 11 years and 3 months in prison after being found guilty of four counts of wire fraud in January 2022. She was found guilty of deceiving investors about the capabilities of Theranos, the blood-testing company she founded in 2003. The company crumbled after a Wall Street Journal story outlined the firm's struggles and shut down in 2018.

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