Researchers have developed a nasal Alzheimer's vaccine that was successful in reducing atrophied brain matter in mice by blocking a protein that causes the disease. It also reduced changes and abnormal behavior in the brain normally associated with the disease. The study was published in the journal Nature. Interesting Engineering reports: "Much more research is necessary for the vaccine to be used in humans, but it is an accomplishment that can contribute to the development of a dementia cure," team member Haruhisa Inoue, a professor at Kyoto University, told The Asahi Shimbun. Alzheimer's disease and other forms of dementia are characterized by an abnormal accumulation of tau proteins in the brain. In the study, the research team incorporated a gene into a harmless virus to make it produce tau.

They then administered the virus nasally to mice with genes that made them prone to developing dementia. The vaccine proceeded to stimulate the mice's immune system, causing them to build antibodies that removed the tau proteins. These antibodies were more than double in mice who had the vaccine administered compared to those that did not. In addition, the vaccinated mice's brain areas were only two-thirds as atrophied as those who were not vaccinated. Finally, no detrimental side effects were recorded during the eight months the scientists observed the mice.

The coronavirus has proven ten times deadlier than the swine flu outbreak that spread across the globe a decade prior, the World Health Organization has confirmed. The Independent reports: The swine flu pandemic, which spanned a stretch of time between January 2009 and August 2010, saw more than 1.6 million confirmed cases, resulting in the confirmed deaths of 18,449 people. Now the World Health Organization's top official Tedros Adhanom Ghebreyesus has warned the coronavirus pandemic currently gripping the planet has outstripped the fatalities caused by the H1N1 strain tenfold.

"We can only say what we know, and we can only act on what we know," he said. "Evidence from several countries is giving us a clearer picture about this virus, how it behaves, how to stop it and how to treat it. We know that Covid-19 spreads fast and we know that it is deadly -- ten times deadlier than the 2009 flu pandemic. We know that the virus can spread more easily in crowded environments like nursing homes. We know that early case finding, testing, isolating, caring for every case, and tracing every contact is essential for stopping transmission. We know that in some countries cases are doubling every three to four days. However while Covid-19 accelerates very fast it decelerates much more slowly. In other words the way down is much slower than the way up. That means control measures must be lifted slowly and with control."

gollum123 shares a report from CNN: States on the country's East and West coasts are forming their own regional pacts to work together on how to reopen from the stay-at-home orders each has issued to limit the spread of the novel coronavirus. The first such group to be announced came Monday on the East Coast. Democratic New York Gov. Andrew Cuomo said his state, New Jersey, Connecticut, Pennsylvania, Delaware and Rhode Island each plan to name a public health and economic official to a regional working group. The chief of staff of the governor of each state also will be a part of the group, which will begin work immediately to design a reopening plan. Later on Monday, the West Coast states of California, Washington and Oregon also announced they are joining forces in a plan to begin incremental release of stay-at-home orders. When announcing the three-state coordination of the western governors during his midday briefing on Monday, Newsom quoted an old proverb: "If you want to go fast, go alone, but if you want to go far, go together." The report notes that other regional pacts could be in the works as well.

"Minnesota Gov. Tim Walz told reporters on Monday that he spoke with Michigan Gov. Gretchen Whitmer and Wisconsin Gov. Tony Evers about working together to open those states from their respective stay-at-home orders," reports CNN. "But the only way that this can happen is if we have widespread testing," Walz said.

kbahey shares a report from Planet Princeton: Renowned mathematician and Princeton University professor John Horton Conway died April 11 as a result of complications from the coronavirus. He was 82. Conway made contributions to many areas of mathematics, including game theory, but was most well known for the invention of the cellular automaton called the Game of Life. The Guardian once called Conway the world's most charismatic mathematician. "John Horton Conway is a cross between Archimedes, Mick Jagger and Salvador Dali. For many years, he worried that his obsession with playing silly games was ruining his career -- until he realized that it could lead to extraordinary discoveries," wrote journalist Siobhan Roberts in a 2015 profile.

There are 70 coronavirus vaccines in development globally, with three candidates already being tested in human trials, according to the World Health Organization, as drugmakers race to find a cure for the deadly pathogen. From a report: The furthest along in the clinical process is an experimental vaccine developed by Hong Kong-listed CanSino Biologics and the Beijing Institute of Biotechnology, which is in phase 2. The other two being tested in humans are treatments developed separately by U.S. drugmakers Moderna and Inovio Pharmaceuticals, according to a WHO document. Progress is occurring at unprecedented speed in developing vaccines as the infectious pathogen looks unlikely to be stamped out through containment measures alone. The drug industry is hoping to compress the time it takes to get a vaccine to market -- usually about 10 to 15 years -- to within the next year.

The UK public will soon be able to find out if they may have been in the vicinity of people unwell with coronavirus via a new contact-tracing app, Matt Hancock, the health secretary, has said. From a report: At No 10's daily press conference on Sunday, Hancock said the NHS app would allow people to report their symptoms, and then the app would anonymously alert other app users that had been in contact with that person in recent days. The Guardian reported last week that the app, developed by NHSX -- the health service's digital transformation arm -- with academic and industry partners, is in the advanced stages of evaluation and is weeks away from being ready to be deployed. About 60% of the adult population would need to sign up and engage with the app by registering their symptoms or positive test results for it to be effective. Their proximity to other users would be logged, and they would follow advice given in alerts to self-isolate -- even in cases where they were not aware of having been in contact with someone infected.

A team in Colombia is to test a ventilator made with a Raspberry Pi computer and easy-to-source parts. From a report: The design and computer code were posted online in March by a man in California, who had no prior experience at creating medical equipment. Marco Mascorro, a robotics engineer, said he built the ventilator because knew the machines were in high demand to treat Covid-19. His post prompted a flood of feedback from healthcare workers. He has used the advice to make improvements. "I am a true believer that technology can solve a lot of the problems we have right now specifically in this pandemic," he told the BBC. The Colombian team said the design was important for their South American country because parts for traditional models could be hard to obtain. By contrast, Mr Mascorro's design uses only easy-to-find parts -- for example, the valves it employs can commonly be found at car and plumbing supply stores. The machine is set to be put through a fast-tracked round of tests at two institutions in Bogota -- the University Hospital of the Pontifical Xavierian University and Los Andes University.

Yahoo News shares an encouraging report from former Newsweek correspondent Andrew Romano: Until very recently, nationwide data about how many COVID-19 patients are currently receiving treatment in hospitals was hard to come by. It's still incomplete and inconsistent. But on April 7, researchers at the University of Minnesota launched the U.S. COVID-19 Hospitalization Tracking Project, which is just what it sounds like: the first effort to capture, track, visualize and compare daily data on the number of COVID-19 hospitalizations from the 37 state departments of health that are reporting this information (so far).

The reason this information is so valuable is simple. Because hospitalization typically occurs a week or so after infection, it's less of a lagging indicator than the death count (which trails by two to two and a half weeks) and more directly tied to the trajectory of the epidemic than the testing-dependent case count. It's also a measure of the most pressing public health concern of all: how close we are to exceeding the capacity of our hospital system, which can make COVID-19 much deadlier than it would otherwise be.

Which brings us to New York and California. Chart each state's hospitalization data over the last seven days or so, and two different narratives emerge. Both are encouraging...

On Wednesday, New York's daily death count hit an all-time high: 799. But that reflects infections from weeks ago, before the state's lockdown started. The number of people testing positive stayed relatively flat. Meanwhile, there were fewer new hospitalizations — just 200 — than on any day since March 18. It wasn't a blip. The amount of new daily hospitalizations has been declining since last Thursday: from 1,427 on April 2 to 1,095 on April 3 to 656 on April 6 to 200 on April 8. (There are some questions about inconsistencies between the data from New York state and New York City, but the trend line is the same.) Previously, the total current number of coronavirus patients in New York hospitals had been increasing by at least 20 percent a day for weeks. Now the overall number of hospitalizations is barely increasing at all...

The good news in New York is that the state might be peaking now. The good news in California is that the state might not peak for a long time — but its path to that peak will be so incremental, its curve so flat, that coronavirus patients will never come close to overwhelming the hospital system.
The numbers do look encouraging. (Click on the "Currently Hospitalized" rectangle and then select each state's two-letter abbreviation from the dropdown menu.) In fact, the San Francisco Bay Area recorded its fourth day of declining ICU patients on Saturday. "Home-sheltering efforts may well be paying off, at least according to the number of hospitalizations and patients in ICU," reports the Bay Area Newsgroup.

And SFGate noted Friday that the statewide hospitalization figures "have also been relatively flat in recent days, with Governor Gavin Newsom expressing guarded optimism after the number of individuals in intensive care units decreased Thursday."

sciencehabit writes: Recycling isn't as guilt-free as it seems. Only about 30% of the plastic that goes into soda bottles gets turned into new plastic, and it often ends up as a lower strength version. Now, researchers report they've engineered an enzyme that can convert 90% of that same plastic back to its pristine starting materials. Work is underway to scale up the technology and open a demonstration plant next year.

The researchers generated hundreds of mutant enzymes changing amino acids as they went. They then mass produced the mutants in bacteria and screened them to find efficient breakers of plastic bonds. After repeating this process for several rounds, they isolated a mutant enzyme that's 10,000 times more efficient at breaking down an important bond that allows plastic to be recycled.

The team is currently building a demonstration plant that is expected to recycle hundreds of tons of plastic per year. The enzyme can't recycle other major types of plastics, such as polyethylene and polystyrene, which have bonds between building blocks that are harder to break. But if successful, it could make it help society deal with one of the most challenging plastic problems we face.
John McGeehan, who directs the center for enzyme innovation at the University of Portsmouth, also tells Science that now recycling companies typically melt plastics together to make carpets or other low-grade plastic fibers that will eventually end up in a landfill or get incinerated.

"It's not really recycling at all."

This week the Washington Post asked their "business of health care" reporter to explain the true status in the scientific community of hydroxychloroquine, an already-approved malaria drug also used to control inflammation in lupus and rheumatoid arthritis patients.

"There is no clear evidence that the drugs work against the coronavirus," he writes, "despite their use by hospitals and doctors in the United States and other countries since the outbreak began." Their antiviral properties have been proved in test tubes, but rigorous clinical trials to test their effectiveness in humans have not been completed. Limited studies on coronavirus patients have been published by researchers in France and China, but their extremely small size and other problems prevented them from being statistically significant. The French study included a combination of hydroxychloroquine with the antibiotic azithromycin that showed benefit in six patients... Another study in 11 patients in France showed no evidence the regimen works. A Chinese study also showed no benefit over the standard course of treatment.

Mainstream scientists caution against using the drugs without more evidence they are effective... The dangerous side effects of the drugs are much better known. Most seriously, the drugs can trigger arrhythmia, which can lead to a fatal heart attack in patients with cardiovascular disease or who are taking certain drugs, including anti-depression medications. Doctors recommend screening with an electrocardiogram to prevent the drug from being given to the 1 percent of patients at the greatest risk of a cardiac event. The drugs also can cause vision loss called retinopathy with long-term use, and chloroquine has been associated with psychosis...

As the coronavirus has spread from China across the world and to the United States, the dire reality is that there is no vaccine and no approved drug available to treat the serious respiratory symptoms that are claiming thousand of lives.
Long-time Slashdot reader UnknowingFool shares doubts raised about that small French study, as even its publisher now acknowledges it "does not meet" their own expected standards.

The Post does note that multiple trials are "ongoing" (though six different research centers testing the drug told CNN it would be "months" before results were known). But the Post adds that already "public and political interest has caused runs, hoarding and severe shortages in recent weeks."

An anonymous reader quotes Reuters: U.S. deaths due to the coronavirus surpassed 20,000 on Saturday, the highest reported number in the world, according to a Reuters tally, although there are signs the pandemic might be nearing a peak. Italy has the second most reported deaths at 19,468 and Spain is in third place with 16,353.

The United States has five times the population of Italy and nearly seven times the population of Spain.

The United States has seen its highest death tolls to date in the epidemic with roughly 2,000 deaths a day reported for the last four days in a row.
While America has 4.3% of the world's population, it appears to have nearly 20% of the world's 100,000 confirmed fatalities from COVID-19. [Update: This comparison might be skewed by countries underreporting their fatalities.] Long-time blogger Jason Kottke notes the virus is now causing more deaths per day in the U.S. than any other cause, including heart disease and cancer.

But earlier this week Kottke also shared graphs from six different countries visualizing positive new statistics from the Imperial College team suggesting social distancing has worked in 11 European countries they analyzed.

"We estimate that interventions across all 11 countries will have averted 59,000 deaths up to 31 March," the researchers write, adding "Many more deaths will be averted through ensuring that interventions remain in place until transmission drops to low levels."

Long-time Slashdot reader lkcl quotes NASA: Over the past several weeks, NASA satellite measurements have revealed significant reductions in air pollution over the major metropolitan areas of the Northeast United States. Similar reductions have been observed in other regions of the world....

March 2020 shows the lowest monthly atmospheric nitrogen dioxide levels of any March during the OMI data record, which spans 2005 to the present. In fact, the data indicate that the nitrogen dioxide levels in March 2020 are about 30% lower on average across the region of the I-95 corridor from Washington, DC to Boston than when compared to the March mean of 2015-19.

RadioShack's former CEO tells Canada's National Post newspaper the surprising story of what happened after he left the company in 2004: When it came, rather than being crestfallen, he felt liberated, and free to pursue an "itch" that he had always felt the need to scratch. So he applied to medical school at McMaster University in Hamilton, Ontario... "I don't miss being a CEO one bit," Levy says. "I enjoyed it immensely, when I was doing it. But do I enjoy what I am doing now? The answer is, immensely."

Brian Levy, MD, was talking about his unusual career path with a reporter, via a socially-distanced phone call, on an April afternoon after wrapping up an overnight shift in the Emergency Department at Brampton Civic Hospital, northwest of Toronto. Brampton Civic is among the busiest emergency departments in Canada. The former CEO initially fancied becoming a psychiatrist, given all his years managing people, but he realized early on in medical school that he was more of a generalist, not to mention a Type-A, adrenaline-junky.

"Emergency medicine is a perfect fit for my personality," he says.
The article notes Levy's department "is eerily quiet, preparing for an expected surge in COVID-19 cases" -- and that in his spare time he's still an electronics geek.

"I am just one of those people who was very fortunate, where things worked out, and where I could do not just do one thing I really enjoyed in life, but two."

The New York Post reports that a COVID-19 vaccine "may be six months away, according to a researcher leading a team of scientists in England." "I think there's a high chance that it will work based on other things that we have done with this type of vaccine," Sarah Gilbert, a professor of virology at Oxford told The Times of London. "It's not just a hunch and as every week goes by we have more data to look at. I would go for 80 percent, that's my personal view."
Gilbert added that if they can find places that haven't imposed a lockdown, "we will get our efficacy results very quickly."

America and Israel have also reported encouraging progress on a vaccine. And in the Netherlands and Australia, researchers are testing the effectiveness of the BCG tuberculosis vaccine developed in the 1920s (with more tests being scheduled for Africa, and experiments in the U.K.) UPI reports researchers in the Netherlands "have started recruiting 1,000 healthcare workers, who are at high risk for COVID-19, in eight hospitals who will receive either the BCG vaccine or a placebo."

The Times of London reports that the U.K. government "signalled that it would be willing to fund the manufacture of millions of doses in advance" if the results of professor Gilbert's research looked promising. "This would allow it to be available immediately to the public if it were proven to work.

"With ministers struggling to find a strategy to exit the lockdown, long-term hopes of a return to normality rely on a vaccine."

An anonymous reader quotes a report from Technology Networks: According to a popular view, creativity is a product of the brain's right hemisphere -- innovative people are considered "right-brain thinkers" while "left-brain thinkers" are thought to be analytical and logical. Neuroscientists who are skeptical of this idea have argued that there is not enough evidence to support this idea and an ability as complex as human creativity must draw on vast swaths of both hemispheres. A new brain-imaging study out of Drexel University's Creativity Research Lab sheds light on this controversy by studying the brain activity of jazz guitarists during improvisation. The study, which was recently published in the journal NeuroImage, showed that creativity is, in fact, driven primarily by the right hemisphere in musicians who are comparatively inexperienced at improvisation. However, musicians who are highly experienced at improvisation rely primarily on their left hemisphere. This suggests that creativity is a "right-brain ability" when a person deals with an unfamiliar situation but that creativity draws on well-learned, left-hemisphere routines when a person is experienced at the task. "[W]hen a person is an expert, his or her performing is produced primarily by relatively unconscious, automatic processes that are difficult for a person to consciously alter, but easy to disrupt in the attempt, as when self-consciousness causes a person to 'choke' or falter," the report says. "In contrast, novices' performances tend to be under deliberate, conscious control. Thus, they are better able to make adjustments according to instructions given by a teacher or coach."

"Recordings of brain activity could reveal the point at which a performer is ready to release some conscious control and rely on unconscious, well-learned routines. Releasing conscious control prematurely may cause the performer to lock-in bad habits or nonoptimal technique."

hackingbear writes: After testing blood from 500 residents for antibodies to the COVID-19 virus in the town of Gangelt, which is a hot spot of the pandemic in Germany, scientists at a nearby university say they have determined that 14% have been infected and are therefore "immune." Some of those people would have had no symptoms at all. Scientists found that 2% of residents were actively infected by the coronavirus and a total of 14% had antibodies, indicating a prior infection. "From the result of their blood survey, the German team estimated the death rate in the municipality at 0.37% overall, a figure significantly lower than what's shown on a dashboard maintained by Johns Hopkins, where the death rate in Germany among reported cases is 2%," reports MIT Technology Review. In contrast, the 2019-2020 seasonal flu has infected up to 17% of U.S. population and killed ~0.1% of those infected. Since first emerged in late December, or purportedly as early as late November, the COVID-19 has infected over 1.6 million people and killed over 100,000.

Marcia Dunn from The Associated Press remembers the Apollo 13 mission 50 years later: Apollo 13âs astronauts never gave a thought to their mission number as they blasted off for the moon 50 years ago. Even when their oxygen tank ruptured two days later â" on April 13. Jim Lovell and Fred Haise insist they're not superstitious. They even use 13 in their email addresses. As mission commander Lovell sees it, he's incredibly lucky. Not only did he survive NASA's most harrowing moonshot, he's around to mark its golden anniversary. "I'm still alive. As long as I can keep breathing, I'm good," Lovell, 92, said in an interview with The Associated Press from his Lake Forest, Illinois, home. A half-century later, Apollo 13 is still considered Mission Control's finest hour. Lovell calls it "a miraculous recovery." Haise, like so many others, regards it as NASA's most successful failure. "It was a great mission," Haise, 86, said. It showed "what can be done if people use their minds and a little ingenuity."

wiredmikey writes from a report via SecurityWeek: Authorities in Italy are using Drones equipped with heat sensors to take the temperature of citizens and send the information to a drone operator, who has a thermal map on his hand-held screen -- shining orange and purple blobs. The hovering drone emits a mechanical buzz reminiscent of a wasp and shouts down instructions in a tinny voice. "Attention! You are in a prohibited area. Get out immediately," commands the drone, about the size of a loaf of bread. "Violations of the regulations result in administrative and criminal penalties," the drone says. "Once a person's temperature is read by the drone, you must still stop that person and measure their temperature with a normal thermometer," Matteo Copia, a police commander, said. Copia says the local police force has received new powers that allow it to check people's temperature without their knowledge or permission.

A prototype smart toilet that can identify you by your "analprint" and monitor your trip to the loo has been created by researchers at Stanford University. It's equipped with cameras and sensors that collect information on your bodily waste, and it uses that data to look for any health issues you might have. The Verge reports: The "analprint" is the toilet's primary way of identifying each user. Much to the authors' dismay, it's also the aspect of the toilet that's gotten the most attention since the paper describing the proto-toilet was published in a press release and the journal Nature Biomedical Engineering on Monday.

The idea for an analprint was sparked by Salvador Dali, who discovered that "the anus has 35 or 37 creases, which are as unique as fingerprints," Park wrote in a blog post. The prototype device -- which is modular and can be attached to most standard toilets -- uses a Raspberry Pi paired with a camera to capture each person's unique analprint as they sit down to use the toilet, ensuring the data it captures is associated with the correct person. The real action happens after the person sits down, according to Park. Inside the toilet, there are cameras to capture images of the person and their waste, motion sensors to detect urine streams, and medical sensors to analyze what's inside the excrement. To further distinguish an individual, the smart toilet also includes a fingerprint scanner on the lever. The smart toilet uses an algorithm to determine "urodynamics," which analyzes the flow rate, magnitude, and stream time of each participant's urine to determine their general health and if they have a bladder infection. Participants' stool was also classified using the "Bristol Stool Form Scale." The first prototype smart toilet can detect constipation and infections, "but the eventual goal is to spot any severe health problems like colon cancer," the report says. It notes that the data and images that are collected "are stored in an encrypted cloud server, which is supposed to keep the information private."