Researchers have identified cells in the human brain that are responsible for episodic memories. The study has been published in the journal Proceedings of the National Academy of Sciences. NPR reports: The cells are called time cells, and they place a sort of time stamp on memories as they are being formed. That allows us to recall sequences of events or experiences in the right order. "By having time cells create this indexing across time, you can put everything together in a way that makes sense," says Dr. Bradley Lega, the study's senior author and a neurosurgeon at the University of Texas Southwestern Medical Center in Dallas. Time cells were discovered in rodents decades ago. But the new study is critical because "the final arbitrator is always the human brain," says Dr. Gyorgy Buzsaki, Biggs Professor of Neuroscience at New York University. Buzsaki is not an author of the study but did edit the manuscript.

Lega and his team found the time cells by studying the brains of 27 people who were awaiting surgery for severe epilepsy. As part of their pre-surgical preparation, these patients had electrodes placed in the hippocampus and another area of the brain involved in navigation, memory and time perception. In the experiment, the patients studied sequences of 12 or 15 words that appeared on a laptop screen during a period of about 30 seconds. Then, after a break, they were asked to recall the words they had seen. Meanwhile, the researchers were measuring the activity of individual brain cells. And they found a small number that that would fire at specific times during each sequence of words.

"The time cells that we found, they are marking out discrete segments of time within this approximately 30-second window," Lega says. These time stamps seemed to help people recall when they had seen each word, and in what order, he says. And the brain probably uses the same approach when we're reliving an experience like falling off a bike. The results help explain why people who have damage to the hippocampus may experience odd memory problems, Buzsaki says.

A Chinese spacecraft is expected to land on Mars in May, state-run media reported on Thursday, citing a space agency official. From a report: The spacecraft, which left Earth in July, is set to land in Utopia Planitia, a plain in the northern hemisphere of Mars, the China News Service reported, citing Liu Tongjie, spokesman for the Mars mission. Separate spacecraft launched by the United States and the United Arab Emirates this year are also en route to Mars, though only the U.S. one will attempt a landing.

Since 2000, there have always been humans living and working on the International Space Station -- and the streak could just be getting started. National Geographic reports: On Halloween in the year 2000, a Russian Soyuz rocket launched from the Baikonur Cosmodrome in Kazakhstan and flew into the history books, carrying one U.S. astronaut and two Russian cosmonauts to the nascent International Space Station (ISS). The crew arrived two days later, and the space station has been continuously occupied by humans ever since, a 20-year streak of living and working in low-Earth orbit. "There's kids now who are in college who, for their entire lives, we've been living off the planet," says Kenny Todd, NASA's deputy program manager for the ISS. "When I was a kid, that was all stuff that was just dreams."

The orbiting laboratory is among the most expensive and technologically complex objects ever built: a $150-billion pressurized habitat as long as a football field, whizzing 254 miles above Earth's surface at 17,000 miles an hour. Over the decades, 241 women and men from around the world have temporarily called the space station home, some for nearly a full year at a time. "It's pretty crazy -- I'm surprised we haven't, like, really seriously hurt anybody," says retired NASA astronaut Scott Kelly, who spent nearly a year on one ISS stay. "It's really a testament to the seriousness [with which] people on the ground take this job, the attention to detail."

Upward of a hundred thousand people have worked together to design, build, launch, and operate the sprawling station, says David Nixon, who worked with NASA on ISS designs in the mid-1980s. "When you compare the station to the procession of great structures and buildings built by humanity since the dawn of civilization, it's up there with the Pyramids, the Acropolis -- all the great structures and edifices," he says. The future of the ISS remains uncertain. "The station is currently slated to run until at least 2024, and much of its hardware is certified to operate safely until at least 2028, if not longer for its younger components," the report notes.

"Will the ISS be disassembled and scavenged in orbit to construct a future space station? Will it be turned over to private companies as nations venture farther into space? Will the whole structure go out in a final blaze of glory, steered into a Pacific crash landing like the Russian space station Mir?"

An anonymous reader quotes a report from The Guardian: Scientists have found evidence that frozen methane deposits in the Arctic Ocean -- known as the "sleeping giants of the carbon cycle" -- have started to be released over a large area of the continental slope off the East Siberian coast, the Guardian can reveal. High levels of the potent greenhouse gas have been detected down to a depth of 350 meters in the Laptev Sea near Russia, prompting concern among researchers that a new climate feedback loop may have been triggered that could accelerate the pace of global heating.

The slope sediments in the Arctic contain a huge quantity of frozen methane and other gases -- known as hydrates. Methane has a warming effect 80 times stronger than carbon dioxide over 20 years. The United States Geological Survey has previously listed Arctic hydrate destabilization as one of four most serious scenarios for abrupt climate change. The international team onboard the Russian research ship R/V Akademik Keldysh said most of the bubbles were currently dissolving in the water but methane levels at the surface were four to eight times what would normally be expected and this was venting into the atmosphere. The scientists -- who are part of a multi-year International Shelf Study Expedition -- stressed their findings were preliminary. The scale of methane releases will not be confirmed until they return, analyze the data and have their studies published in a peer-reviewed journal. But the discovery of potentially destabilized slope frozen methane raises concerns that a new tipping point has been reached that could increase the speed of global heating.

fahrbot-bot shares a press release from NASA: NASA's Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS-REx) mission has successfully stowed the spacecraft's Sample Return Capsule (SRC) and its abundant sample of asteroid Bennu. On Wednesday, Oct. 28, the mission team sent commands to the spacecraft, instructing it to close the capsule -- marking the end of one of the most challenging phases of the mission.

The mission team spent two days working around the clock to carry out the stowage procedure, with preparations for the stowage event beginning Oct. 24. The process to stow the sample is unique compared to other spacecraft operations and required the team's continuous oversight and input over the two-day period. For the spacecraft to proceed with each step in the stowage sequence, the team had to assess images and telemetry from the previous step to confirm the operation was successful and the spacecraft was ready to continue. Given that OSIRIS-REx is currently more than 205 million miles (330 million km) from Earth, this required the team to also work with a greater than 18.5-minute time delay for signals traveling in each direction.

Throughout the process, the OSIRIS-REx team continually assessed the Touch-And-Go Sample Acquisition Mechanism's (TAGSAM) wrist alignment to ensure the collector head was being placed properly into the SRC. Additionally, the team inspected images to observe any material escaping from the collector head to confirm that no particles would hinder the stowage process. StowCam images of the stowage sequence show that a few particles escaped during the stowage procedure, but the team is confident that a plentiful amount of material remains inside of the head. By the evening of Oct. 27, the spacecraft's TAGSAM arm had placed the collector head into the SRC. The following morning, the OSIRIS-REx team verified that the collector head was thoroughly fastened into the capsule by performing a "backout check." This sequence commanded the TAGSAM arm to attempt to back out of the capsule -- which tugged on the collector head and ensured the latches are well secured.

Microsoft is overhauling Excel with the ability to support custom live data types. The Verge reports: You could import the data type for Seattle, for example, and then create a formula that references that single cell to pull out information on the population of Seattle. These data types work by cramming a set of structured data into a single cell in Excel that can then be referenced by the rest of the spreadsheet. Data can also be refreshed to keep it up to date. If you're a student who is researching the periodic table, for example, you could create a cell for each element and easily pull out individual data from there.

Microsoft is bringing more than 100 new data types into Excel for Microsoft 365 Personal or Family subscribers. Excel users will be able to track stocks, pull in nutritional information for dieting plans, and much more, thanks to data from Wolfram Alpha's service. This is currently available for Office beta testers in the Insiders program. Where these custom data types will be most powerful is obviously for businesses that rely on Excel daily. Microsoft is leveraging its Power BI service to act as the connector to bring sources of data into Excel data types on the commercial side, allowing businesses to connect up a variety of data. This could be hierarchical data or even references to other data types and images. Businesses will even be able to convert existing cells into linked data types, making data analysis a lot easier.

Power BI won't be the only way for this feature to work, though. When you import data into Excel, you can now transform it into a data type with Power Query. That could include information from files, databases, websites, and more. The data that's imported can be cleaned up and then converted into a data type to be used in spreadsheets. If you've pulled in data using Power Query, it's easy to refresh the data from its original source. [...] These new Power BI data types will be available in Excel for Windows for all Microsoft 365 / Office 365 subscribers that also have a Power BI Pro service plan. Power Query data types are also rolling out to subscribers. On the consumer side, Wolfram Alpha data types are currently available in preview for Office insiders and should be available to all Microsoft 365 subscribers soon.

A reader shares a report from Observer: NASA's Hubble Space Telescope has discovered a rare, heavy and immensely valuable asteroid called "16 Psyche" in the Solar System's main asteroid belt between Mars and Jupiter. Asteroid Psyche is located at roughly 230 million miles (370 million kilometers) from Earth and measures 140 miles (226 kilometers) across, about the size of West Virginia. What makes it special is that, unlike most asteroids that are either rocky or icy, Psyche is made almost entirely of metals, just like the core of Earth, according to a study published in the Planetary Science Journal on Monday.

Given the asteroid's size, its metal content could be worth $10,000 quadrillion ($10,000,000,000,000,000,000), or about 10,000 times the global economy as of 2019. Using ultraviolet spectrum data collected by the Space Telescope Imaging Spectrograph on the Hubble Space Telescope during two observations in 2017, researchers deduced that Psyche's surface could be mostly pure iron. However, they recognized that the presence of an iron composition of as small as 10 percent could dominate ultraviolet observations. Psyche is the target of the NASA Discovery Mission Psyche, expected to launch in 2022 atop a SpaceX Falcon Heavy rocket. Further facts about the asteroid, including its exact metal content, will hopefully be uncovered when an orbiting probe arrives in early 2026. The asteroid is believed to be the dead core left by a planet that failed during its formation early in the Solar System's life or the result of many violent collisions in its distant past.

An anonymous reader quotes a report from the BBC: An enormous coral reef has been found at the northern tip of Australia's Great Barrier Reef, the first such discovery in 120 years, scientists say. At 500m (1,640ft) high, the reef is taller than New York's Empire State Building and the Petronas Twin Towers in Kuala Lumpur, Malaysia. Scientists on a 12-month mission found the structure, detached from the Great Barrier Reef off Cape York, last week. They were conducting 3D mapping of the sea floor in the area. A team aboard a research vessel owned by the Schmidt Ocean Institute (SOI), a non-profit group based in California, used an underwater robot to explore the reef.

The reef is the first of its kind to be found in the region since the late 1800s, scientists said. There are known to be seven other tall reefs in the region, including the one at Raine Island -- the world's most important green sea turtle nesting area. While the reef is bedded to the ocean floor off North Queensland, it is detached, meaning it is not part of the main body of the Great Barrier Reef. Described as "blade-like," the reef is 1.5km wide (one mile), then rises 500m to its shallowest depth of only 40m below the sea surface. Researchers are expected to continue surveying the northern Great Barrier Reef until 17 November.

NASA's Mars 2020 Perseverance rover mission has logged a lot of flight miles since being lofted skyward on July 30 -- 146.3 million miles (235.4 million kilometers) to be exact. Turns out that is exactly the same distance it has to go before the spacecraft hits the Red Planet's atmosphere like a 11,900 mph (19,000 kph) freight train on Feb. 18, 2021. From a report: "At 1:40 p.m. Pacific Time today, our spacecraft will have just as many miles in its metaphorical rearview mirror as it will out its metaphorical windshield," said Julie Kangas, a navigator working on the Perseverance rover mission at NASA's Jet Propulsion Laboratory in Southern California. "While I don't think there will be cake, especially since most of us are working from home, it's still a pretty neat milestone. Next stop, Jezero Crater." The Sun's gravitational influence plays a significant role in shaping not just spacecraft trajectories to Mars (as well as to everywhere else in the solar system), but also the relative movement of the two planets. So Perseverance's route to the Red Planet follows a curved trajectory rather than an arrow-straight path.

"Although we're halfway into the distance we need to travel to Mars, the rover is not halfway between the two worlds," Kangas explained. "In straight-line distance, Earth is 26.6 million miles [42.7 million kilometers] behind Perseverance and Mars is 17.9 million miles [28.8 million kilometers] in front." At the current distance, it takes 2 minutes, 22 seconds for a transmission to travel from mission controllers at JPL via the Deep Space Network to the spacecraft. By time of landing, Perseverance will have covered 292.5 million miles (470.8 million kilometers), and Mars will be about 130 million miles (209 million kilometers) away from Earth; at that point, a transmission will take about 11.5 minutes to reach the spacecraft.

omfglearntoplay shares a report from ScienceAlert: Playing through the greenery and litter of a mini forest's undergrowth for just one month may be enough to change a child's immune system, according to a small new experiment. When daycare workers in Finland rolled out a lawn, planted forest undergrowth such as dwarf heather and blueberries, and allowed children to care for crops in planter boxes, the diversity of microbes in the guts and on the skin of young kids appeared healthier in a very short space of time. Compared to other city kids who play in standard urban daycares with yards of pavement, tile and gravel, 3-, 4-, and 5-year-olds at these greened-up daycare centers in Finland showed increased T-cells and other important immune markers in their blood within 28 days.

"We also found that the intestinal microbiota of children who received greenery was similar to the intestinal microbiota of children visiting the forest every day," says environmental scientist Marja Roslund from the University of Helsinki. Prior research has shown early exposure to green space is somehow linked to a well-functioning immune system, but it's still not clear whether that relationship is causal or not. The experiment in Finland is the first to explicitly manipulate a child's urban environment and then test for changes in their micriobiome and, in turn, a child's immune system. While the findings don't hold all the answers, they do support a leading idea -- namely that a change in environmental microbes can relatively easily affect a well-established microbiome in children, giving their immune system a helping hand in the process. The study was published in the journal Science Advances.

An anonymous reader quotes a report from Network World: The Folding@home project has shared new results of its efforts to simulate proteins from the SARS-CoV-2 virus to better understand how they function and how to stop them. Folding@home is a distributed computing effort that uses small clients to run simulations for biomedical research when users' PCs are idle. The clients operate independently of each other to perform their own unique simulation and send in the results to the F@h servers. In its SARS-CoV-2 simulations, F@h first targeted the spike, the cone-shaped appendages on the surface of the virus consisting of three proteins. The spike must open to attach itself to a human cell to infiltrate and replicate. F@h's mission was to simulate this opening process to gain unique insight into what the open state looks like and find a way to inhibit the connection between the spike and human cells.

And it did so. In a newly published paper, the Folding@home team said it was able to simulate an "unprecedented" 0.1 seconds of the viral proteome. They captured dramatic opening of the spike complex, as well as shape-shifting in other proteins that revealed more than 50 "cryptic" pockets that expand targeting options for the design of antivirals. [...] The model derived from the F@h simulations shows that the spike opens up and exposes buried surfaces. These surfaces are necessary for infecting a human cell and can also be targeted with antibodies or antivirals that bind to the surface to neutralize the virus and prevent it from infecting someone. "And the tech sector played a big role in helping the find," adds the anonymous Slashdot reader. "Microsoft, Nvidia, AMD, Intel, AWS, Oracle, and Cisco all helped with hardware and cloud services. Pure Storage donated a one petabyte all-flash storage array. Linus Tech Tips, a hobbyist YouTube channel for home system builders with 12 million followers, set up a 100TB server to take the load off."

In an effort to curb the second wave of COVID-19, the Russian government on Tuesday implemented a nationwide mask mandate, as coronavirus cases spike worldwide. CBS News reports: Under the new mandate, effective Wednesday, masks will be mandatory in crowded public spaces, such as public transportation, parking lots and elevators, according to the order published on the website for the federal health watchdog agency Rospotrebnadzor, also known as the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. The department has also advised local authorities to ban all entertainment activities, including bars and restaurants, between 11 p.m. and 6 a.m. It recommended strengthening safety protocols on public transport, taxis, shops, restaurants and theaters. People not wearing masks will be refused service in these establishments. However, Moscow authorities said that they are not planning to close nightclubs and bars overnight.

Russia has had over 1,520,000 cases of COVID-19 and over 26,000 deaths since the pandemic began, according to Johns Hopkins University. It recorded a record-high number of new cases on Monday, with 17,148, and October has seen more confirmed cases in the country overall than any other month. [...] The country has the fourth-highest number of COVID-19 cases in the world, behind the United States, India and Brazil.

Japan will be carbon neutral by 2050, its prime minister said this week, making an ambitious pledge to sharply accelerate the country's global warming targets, even as it plans to build more than a dozen new coal-burning power plants in the coming years. From a report: The prime minister, Yoshihide Suga, laid out the goal during his first major policy speech since taking office in September, when Japan's longest-serving leader, Shinzo Abe, abruptly resigned. The announcement came just weeks after China, Japan's regional rival, said it would reduce its net carbon emissions to zero by 2060. Addressing Japan's Parliament, Mr. Suga called for the country to "be carbon neutral in 2050," a declaration that drew loud applause from lawmakers. Achieving that goal will be good not only for the world, he said, but also for Japan's economy and global standing. "Taking an aggressive approach to global warming will bring about a transformation in our industrial structure and economic system that will lead to big growth" in the economy, he said, answering critics who have warned of the economic consequences. Japan's new climate pledge is a major upgrade of its previous commitment to reducing greenhouse gases, and necessary if the world hopes to keep a global temperature rise well below 2 degrees, as called for in the 2015 Paris climate accord.

Antibodies against the novel coronavirus declined rapidly in the British population during the summer, a study found on Tuesday, suggesting protection after infection may not be long lasting and raising the prospect of waning immunity in the community. From a report: Scientists at Imperial College London have tracked antibody levels in the British population following the first wave of COVID-19 infections in March and April. Their study found that antibody prevalence fell by a quarter, from 6% of the population around the end of June to just 4.4% in September. That raises the prospect of decreasing population immunity ahead of a second wave of infections in recent weeks that has forced local lockdowns and restrictions. Although immunity to the novel coronavirus is a complex and murky area, and may be assisted by T cells, as well as B cells that can stimulate the quick production of antibodies following re-exposure to the virus, the researchers said the experience of other coronaviruses suggested immunity might not be enduring.

Amid fanfare in March, California officials celebrated the launch of a multimillion-dollar contract with Verily -- Google's health-focused sister company -- that they said would vastly expand COVID testing among the state's impoverished and underserved communities. But seven months later, San Francisco and Alameda counties -- two of the state's most populous -- have severed ties with the company's testing sites amid concerns about patients' data privacy and complaints that funding intended to boost testing in low-income Black and Latino neighborhoods instead was benefiting higher-income residents in other communities. From a report: San Francisco and Alameda are among at least 28 counties, including Los Angeles, where California has paid Verily to boost testing capacity through contracts collectively worth $55 million, according to a spokesperson for the California Governor's Office of Emergency Services. About half of them have received COVID tests through six mobile units that travel among rural areas. Gov. Gavin Newsom has heralded the investment as a game changer in addressing persistent inequities in access to COVID testing across the state that tend to fall along lines of ethnicity and income. The goal, he said in April, touting six new Verily testing sites, was to "make sure we're truly testing California broadly defined, not just parts of California and those that somehow have the privilege of getting ahead of the line." Yet the roadblocks for getting underrepresented populations to use the program soon became apparent to Alameda County officials. In a June letter to California Secretary of Health Mark Ghaly, Oakland Mayor Libby Schaaf and other members of the county's COVID-19 Racial Disparities Task Force raised numerous concerns about the Verily protocols.

Seattle-based Ultra Safe Nuclear Technologies (USNC-Tech) has developed a concept for a new Nuclear Thermal Propulsion (NTP) engine that they claim is safer and more reliable than previous NTP designs and with far greater efficiency than a chemical rocket. The concept could reduce Earth-Mars travel time to just three months. New Atlas reports: According to Dr. Michael Eades, principal engineer at USNC-Tech, the new concept engine is more reliable than previous NTP designs and can produce twice the specific impulse of a chemical rocket. Specific impulse is a measure of a rocket's efficiency. To fuel the concept, UNSC-Tech uses a Fully Ceramic Micro-encapsulated (FCM) fuel to power the engine's reactor. This fuel is based on High-Assay Low Enriched Uranium (HALEU), which is derived from reprocessed civilian nuclear fuel and is enriched to between 5 and 20 percent -- greater than that of civilian reactors and less than that of naval reactors. The fuel is then encapsulated into particles coated with zirconium carbide (ZrC).

The company claims that this fuel is much more rugged than conventional nuclear fuels and can operate at high temperatures. This produces safer reactor designs and a high thrust and specific impulse that could previously only be obtained with highly-enriched uranium. In addition, such fuel can be produced with current supply chains and manufacturing plants. It is hoped the new concept could lead to nuclear engines that reduce deep space mission times drastically, with a crewed mission to Mars arriving in as little as three months. Beyond that, the concept is aimed at a commercial market as well as with NASA and the US Department of Defense, allowing for more ambitious private missions.

An anonymous reader quotes a report from IEEE Spectrum: In April, Guoping Feng and colleagues at MIT, along with [Karl Deisseroth, a neuroscientist and bioengineer at Stanford University] demonstrated a minimally invasive optogenetic system that required drilling a small hole in the skull, then being able to control opsin-expressing neurons six millimeters deep into the brain using blue light. This approach used of a type of opsin that slowly activates neurons in a step-wise manner. In the most recent study [published in the journal Nature Biotechnology], Deisseroth and colleagues sought to instead enable both deep and fast optogenetics without surgery. The Stanford team expressed in the brain cells of mice a powerful new opsin called ChRmine (pronounced like the deep-red color "carmine"), discovered by Deisseroth's group last year in a marine organism. Then, they shined a red light outside the skull and were able to activate neural circuits in the midbrain and brainstem at depths of up to 7 millimeters. With the technique, the scientists turned on and off brain circuits with millisecond precision. "It really worked well, far better than we even expected might be possible," says Deisseroth.

The team then tested the effectiveness of the system. In one instance, they used light to quickly and precisely stop seizures in epileptic mice, and in another to turn on serotonin-producing neurons to promote social behavior in mice. Most optogenetic techniques involve injecting viruses with an opsin gene of choice directly into the brain with a needle. To avoid this, the Stanford team used a type of PHP virus developed at CalTech that can be injected in the blood. The virus then crosses the blood-brain barrier to deliver its payload, an opsin gene, to brain cells. In this case, even the delivery of the gene is noninvasive -- no needle penetrates the brain. Deisseroth's team is now testing the non-invasive technique in fish and collaborating with others to apply it to non-human primates. They're also working with the Seattle-based Allen Institute to develop mouse lines bred with ChRmine in their cells.

NASA has confirmed the presence of water on the moon's sunlit surface, a breakthrough that suggests the chemical compound that is vital to life on Earth could be distributed across more parts of the lunar surface than the ice that has previously been found in dark and cold areas. From a report: "We don't know yet if we can use it as a resource," NASA Administrator Jim Bridenstine said, but he added that learning more about the water is crucial to U.S. plans to explore the moon. The discovery comes from the space agency's Stratospheric Observatory for Infrared Astronomy, or SOFIA -- a modified Boeing 747 that can take its large telescope high into Earth's atmosphere, at altitudes up to 45,000 feet. Those heights allow researchers to peer at objects in space with hardly any visual disruptions from water vapor. The water molecules are in Clavius crater, a large crater in the moon's southern hemisphere. To detect the molecules, SOFIA used a special infrared camera that can discern between water's specific wavelength of 6.1 microns and that of its close chemical relative hydroxyl, or OH. "Data from this location reveal water in concentrations of 100 to 412 parts per million -- roughly equivalent to a 12-ounce bottle of water -- trapped in a cubic meter of soil spread across the lunar surface," NASA said in a release about the discovery.

"This is not puddles of water but instead water molecules that are so spread apart that they do not form ice or liquid water," said Casey Honniball, the lead author of a study about the discovery. The data confirm what experts have suspected, that water might exist on the moon's sunny side. But in recent years, researchers had been able to document only water ice at the moon's poles and other darker and colder areas. Experts will now try to figure out exactly how the water came to form and why it persists. NASA scientists published their findings in the latest issue of Nature Astronomy.

One of the world's leading COVID-19 experimental vaccines produces an immune response in both young and old adults, raising hopes of a path out of the gloom and economic destruction wrought by the novel coronavirus. From a report: The vaccine, developed by the University of Oxford, also triggers lower adverse responses among the elderly, British drug maker AstraZeneca Plc, which is helping manufacture the vaccine, said on Monday. A vaccine that works is seen as a game-changer in the battle against the novel coronavirus, which has killed more than 1.15 million people, shuttered swathes of the global economy and turned normal life upside down for billions of people. "It is encouraging to see immunogenicity responses were similar between older and younger adults and that reactogenicity was lower in older adults, where the COVID-19 disease severity is higher," an AstraZeneca spokesman said. "The results further build the body of evidence for the safety and immunogenicity of AZD1222," the spokesman said, referring to the technical name of the vaccine. The Oxford/AstraZeneca vaccine is expected to be one of the first from big pharma to secure regulatory approval, along with Pfizer and BioNTech's candidate, as the world tries to plot a path out of the COVID-19 pandemic.

"TCP/IP doesn't work at interplanetary distances," 77-year-old Vinton Cerf tells Quanta magazine. "So we designed a set of protocols that do." Specifically, bundle protocols: a disruption/delay-tolerant networking (DTN) protocol with nodes that can also store information: A data packet traveling from Earth to Jupiter might, for example, go through a relay on Mars, Cerf explained. However, when the packet arrives at the relay, some 40 million miles into the 400-million-mile journey, Mars may not be oriented properly to send the packet on to Jupiter. "Why throw the information away, instead of hanging on to it until Jupiter shows up?" Cerf said. This store-and-forward feature allows bundles to navigate toward their destinations one hop at a time, despite large disruptions and delays...

So, a couple decades after conceiving of bundle protocols, is the interplanetary internet up and running?

We don't have to build the whole thing and then hope somebody uses it. We sought to get standards in place, as we have for the internet; offer those standards freely; and then achieve interoperability so that the various spacefaring nations could help each other. We're taking the next obvious step for multi-mission infrastructure: designing the capability for an interplanetary backbone network. You build what's needed for the next mission. As spacecraft get built and deployed, they carry the standard protocols that become part of the interplanetary backbone. Then, when they finish their primary scientific mission, they get repurposed as nodes in the backbone network. We accrete an interplanetary backbone over time.

In 2004, the Mars rovers were supposed to transmit data back to Earth directly through the deep space network — three big 70-meter antennas in Australia, Spain and California. However, the channel's available data rate was 28 kilobits per second, which isn't much. When they turned the radios on, they overheated. They had to back off, which meant less data would come back. That made the scientists grumpy. One of the JPL engineers used prototype software — this is so cool! — to reprogram the rovers and orbiters from hundreds of millions of miles away. We built a small store-and-forward interplanetary internet with essentially three nodes: the rovers on the surface of Mars, the orbiters and the deep space network on Earth. That's been running ever since.

We've been refining the design of those protocols, implementing and testing them. The latest protocols are running back-and-forth relays between Earth and the International Space Station... We did another test at the ISS where the astronauts were controlling a little robot vehicle in Germany.