Medicine

Laughing Gas Can Help Treat Depression, Small Study Finds (gizmodo.com) 90

PolygamousRanchKid shares a report from Gizmodo: A dose of laughing gas may just help some people with hard-to-treat depression, suggests a new, small clinical trial published Wednesday. The study found that people who inhaled nitrous oxide reported improvements in their depression symptoms afterward. It also found that people felt similar improvements with a smaller dose as they did with a larger one, but experienced substantially fewer side effects. Nitrous oxide (NO) is a colorless, non-flammable gas at room temperature that's long been used as an anesthetic and sometimes as a recreational drug, due to the euphoria and dissociative hallucinations it can cause upon inhalation. But several years ago, Peter Nagele, a researcher and trauma anesthesiologist at the University of Chicago, and his colleagues began looking into nitrous oxide as a potential treatment for depression.

The small trial recruited 28 participants in a crossover design, which is when all the volunteers go through each of the trial's conditions and their responses are compared to one another (as opposed to two or more distinct groups that either take the drug or placebo). The team found that these volunteers on average experienced a greater improvement in depression symptoms when they took the nitrous oxide at either dose than they did after taking the placebo (based on the primary survey they completed) -- an improvement that lasted for up to two weeks. Some doctors and patients had been using generic ketamine, taken through IV, as an experimental depression treatment for years. But Johnson & Johnson didn't fund expensive clinical trials to secure an approval for ketamine as a depression treatment; it instead developed a patentable form taken as a nasal spray, called esketamine. That sort of commercialization isn't something that's possible with nitrous oxide, according to Nagale.
The study has been published in the journal Science Translational Medicine.
Medicine

CDC To Meet On Rare Heart Inflammation Following COVID Vaccine (yahoo.com) 114

An anonymous reader quotes a report from Reuters: The Centers for Disease Control and Prevention announced Thursday that will convene an "emergency meeting" of its advisers on June 18th to discuss rare but higher-than-expected reports of heart inflammation following doses of the mRNA-based Pfizer and Moderna COVID-19 vaccines. So far, the CDC has identified 226 reports that might meet the agency's "working case definition" of myocarditis and pericarditis following the shots, the agency disclosed Thursday. The vast majority have recovered, but 41 had ongoing symptoms, 15 are still hospitalized, and 3 are in the intensive care unit. The reports represent just a tiny fraction of the nearly 130 million Americans who have been fully vaccinated with either Pfizer or Moderna's doses.

"It's a bit of an apples-to-oranges comparison because, again, these are preliminary reports. Not all these will turn out to be true myocarditis or pericarditis reports," cautioned Dr. Tom Shimabukuro, a CDC vaccine safety official. Shimabukuro said their findings were mostly "consistent" with reports of rare cases of heart inflammation that had been studied in Israel and reported from the U.S. Department of Defense earlier this year. The CDC is working on more data and analysis on the reports ahead of the emergency meeting of its own advisers next week, he said, and also planned to analyze the risk of heart inflammation posed by catching COVID-19. The new details about myocarditis and pericarditis emerged first in presentations to a panel of independent advisers for the Food and Drug Administration, who are meeting Thursday to discuss how the regulator should approach emergency use authorization for using COVID-19 vaccines in younger children.

Medicine

'Miraculous' Mosquito Hack Cuts Dengue By 77% (bbc.com) 67

Dengue fever cases have been cut by 77% in a "groundbreaking" trial that manipulates the mosquitoes that spread it, say scientists. The BBC reports: They used mosquitoes infected with "miraculous" bacteria that reduce the insect's ability to spread dengue. The trial took place in Yogyakarta city, Indonesia, and is being expanded in the hope of eradicating the virus. The World Mosquito Programme team says it could be a solution to a virus that has gone around the world. The trial used mosquitoes infected with Wolbachia bacteria. One of the researchers, Dr Katie Anders, describes them as "naturally miraculous." Wolbachia doesn't harm the mosquito, but it camps out in the same parts of its body that the dengue virus needs to get into. The bacteria compete for resources and make it much harder for dengue virus to replicate, so the mosquito is less likely to cause an infection when it bites again.

The trial used five million mosquito eggs infected with Wolbachia. Eggs were placed in buckets of water in the city every two weeks and the process of building up an infected population of mosquitoes took nine months. Yogyakarta was split into 24 zones and the mosquitoes were released only in half of them. The results, published in the New England Journal of Medicine, showed a 77% reduction in cases and an 86% reduction in people needing hospital care when the insects were released.

Science

The First 'Google Translate' For Elephants Debuts (scientificamerican.com) 50

An anonymous reader quotes a report from Scientific American: Elephants possess an incredibly rich repertoire of communication techniques, including hundreds of calls and gestures that convey specific meanings and can change depending on the context. Different elephant populations also exhibit culturally learned behaviors unique to their specific group. Elephant behaviors are so complex, in fact, that even scientists may struggle to keep up with them all. Now, to get the animals and researchers on the same page, a renowned biologist who has been studying endangered savanna elephants for nearly 50 years has co-developed a digital elephant ethogram, a repository of everything known about their behavior and communication.

[Joyce Poole, co-founder and scientific director of ElephantVoices, a nonprofit science and conservation organization, and co-creator of the new ethogram] built the easily searchable public database with her husband and research partner Petter Granli after they came to realize that scientific papers alone would no longer cut it for cataloging the discoveries they and others were making. The Elephant Ethogram currently includes more than 500 behaviors depicted through nearly 3,000 annotated videos, photographs and audio files. The entries encompass the majority, if not all, of typical elephant behaviors, which Poole and Granli gleaned from more than 100 references spanning more than 100 years, with the oldest records dating back to 1907. About half of the described behaviors came from the two investigators' own studies and observations, while the rest came from around seven other leading savanna elephant research teams.

While the ethogram is primarily driven by Poole and Granli's observations, "there are very few, if any, examples of behaviors described in the literature that we have not seen ourselves," Poole points out. The project is also just beginning, she adds, because it is meant to be a living catalog that scientists actively contribute to as new findings come in. Poole and Granli believe the exhaustive, digitized Elephant Ethogram is the first of its kind for any nonhuman wild animal. The multimedia-based nature of the project is important, Poole adds, because with descriptions based only on the written word, audio files or photographs, "it is hard to show the often subtle differences in movement that differentiate one behavior from another." Now that the project is online, Poole hopes other researchers will begin contributing their own observations and discoveries, broadening the database to include cultural findings from additional savanna elephant populations and unusual behaviors Poole and Granli might have missed.

Medicine

Biden Administration To Buy 500 Million Pfizer Coronavirus Vaccine Doses To Donate To the World (washingtonpost.com) 227

The Biden administration is buying 500 million doses of Pfizer's coronavirus vaccine to donate to the world, as the United States dramatically increases its efforts to help vaccinate the global population, the Washington Post reported Wednesday, citing three people familiar with the plans. From the report: President Biden is slated to announce the plan at the G-7 meeting in Britain this week amid growing calls for the United States and other rich countries to play a more substantial role in boosting the global supply of vaccines. Biden told reporters Wednesday as he boarded Air Force One to Europe he would be announcing his global vaccine strategy. The Biden administration previously announced it would share at least 80 million vaccine doses with the world by the end of June. Last week, the White House detailed plans for how it would allocate 25 million doses, with about 19 million of them being shared with Covax, the World Health Organization-backed initiative to distribute vaccine doses around the globe. Roughly 6 million doses would be shared directly with countries experiencing severe coronavirus outbreaks, including India.
Earth

Whale That Travelled Halfway Around the World Sets Migration Record (newscientist.com) 17

Between May and July of 2013, a single grey whale (Eschrichtius robustus) was spotted off the coast of Namibia. This was odd, as while there have been rare sightings of this species in the Atlantic Ocean, they are usually confined to the northern hemisphere. From a report: It turns out the animal had travelled at least 20,000 kilometres (12,427.4 miles) -- halfway around the planet -- setting a record for a migration of any mammal, barring humans. Rus Hoelzel at Durham University in the UK and his colleagues used tissue samples collected from the whale's skin and analysed its DNA to trace its origins.

By comparing it with other grey whale populations, they found that this individual, a male, was probably born to the endangered western North Pacific population, found along the coast of eastern Asia. This means it travelled at least 20,000 kilometres to get to the southern Atlantic. Earth's circumference is slightly over 40,000 kilometres. "This is the record really for an in-water migration, if you're assuming that this individual started its life in the north-west Pacific and it found its way to Namibia," says Hoelzel. "That's as far as any vertebrate has ever gone in water, as far as we know." Land dwelling mammals fall far short of this feat -- the record is a grey wolf that roamed more than 7000 kilometres in a year.

China

China is Vaccinating a Staggering 20 Million People a Day (nature.com) 210

For more than a week, an average of about 20 million people have been vaccinated against COVID-19 every day in China. At this rate, the nation would have fully vaccinated the entire UK population in little more than six days. From a report: China now accounts for more than half of the 35 million or so people around the world receiving a COVID-19 shot each day. Zoltan Kis, a chemical engineer in the Future Vaccine Manufacturing Research Hub at Imperial College London, doesn't know of "anything even close to those production scales" for a vaccine. "The manufacturing efforts required in China to reach this high production throughput are tremendous," he says. The majority of doses are of one of two vaccines, both of which have been approved for emergency use worldwide by the World Health Organization (WHO). CoronaVac -- produced by Beijing-based company Sinovac -- showed an efficacy of 51% against symptoms of COVID-19 in clinical trials, and much higher protection against severe disease and death. The second jab was developed in Beijing by state-owned firm Sinopharm and has demonstrated an efficacy of 79% against symptomatic disease and hospitalization.
Science

Microscopic Animal Revived After Slumbering in Arctic Permafrost for 24,000 Years (cnn.com) 30

Bdelloid rotifers typically live in watery environments and have an incredible ability to survive. Russian scientists found the creatures in a core of frozen soil extracted from the Siberian permafrost using a drilling rig. CNN reports:"Our report is the hardest proof as of today that multicellular animals could withstand tens of thousands of years in cryptobiosis, the state of almost completely arrested metabolism," said Stas Malavin, a researcher at the Soil Cryology Laboratory at the Pushchino Scientific Center for Biological Research in Russia.

Earlier research by other groups had shown that the rotifers could survive up to 10 years when frozen. In a new study, the Russian researchers used radiocarbon dating to determine that the critters they recovered from the permafrost -- ground that is frozen year-round, apart from a thin layer near the surface -- were about 24,000 years old. The study was published in the journal Current Biology on Monday. It's not the first time ancient life has been resurrected from a permanently frozen habitat.

Science

A 'Bubble Barrier' is Trapping Plastic Waste Before It Can Get Into the Sea (cnn.com) 28

larryjoe writes: A curtain of bubbles in Amsterdam's Westerdok canal filters 86% of trash floating down the canal. The bubbles come from a pipe at the bottom of the canal connected to an air compressor. Holes in the pipe allow the bubbles to float to the water surface, forming a water curtain that pushes trash to the water surface. The curtain is positioned in a skewed orientation to allow the downstream water flow to channel the trash to a catchment system. This novel system catches many types of trash without a physical barrier that impedes vehicles or wildlife. The catchment system only keeps trash that is at least 10mm in size to allow small wildlife to escape. This filtering system is being trialed by a small startup.
Science

Engineers At MIT Have Created Actual Programmable Fibers (interestingengineering.com) 24

Engineers at MIT have recently announced that they have successfully developed a programmable fiber. Interesting Engineering reports: Featured in Nature Communications, this new research could result in the development of wearable tech that could sense, store, analyze, and infer the activity(s) of its wearers in real-time. The senior author of the study, Yeol Fink, believes that digital fibers like those developed in this study could help expand the possibilities for fabrics to "uncover the context of hidden patterns in the human body that could be used for physical performance monitoring, medical inference, and early disease detection." Applications for the technology could even expand into other areas of our lives like, for example, storing wedding music within the bride's gown.

The fibers were created by chaining hundreds of microscale silicon digital chips into a preform to make a new "smart" polymer fiber. By using precision control, the authors of the study were able to create fibers with the continuous electrical connection between each chip of tens of meters. These fibers are thin and flexible and can even be passed through the eye of a needle. This would mean they could be seamlessly (pun intended) woven into existing fabrics, and can even withstand being washed at least ten times without degrading. This would mean this wearable tech could be retrofitted to existing clothing and you wouldn't even know it's there. Such innovation is interesting, but it could open up doors for applications only ever dreamed of.

The fiber also has a pretty decent storage capacity too -- all things considered. During the research, it was found to be possible to write, store, and recall 767-kilobit full-color short movie files and a 0.48-megabyte music file. The files can be stored for two months without power. The fibers also integrate a neural network with thousands of connections. This was used to monitor and analyze the surface body temperature of a test subject after being woven into the armpit of the shirt. By training the neural network with 270-minutes of data the team got it to predict the minute-by-minute activity of the shirt's wearer with 96% accuracy. The fibers are also controlled using a small external device that could have microcontrollers added to it in the future.

Power

Reducing Poverty Can Actually Lower Energy Demand, Finds Research (arstechnica.com) 196

An anonymous reader shares a report from The Conversation: As people around the world escape poverty, you might expect their energy use to increase. But my research in Nepal, Vietnam, and Zambia found the opposite: lower levels of deprivation were linked to lower levels of energy demand. What is behind this counterintuitive finding? [...] We found that households that do have access to clean fuels, safe water, basic education and adequate food -- that is, those not in extreme poverty -- can use as little as half the energy of the national average in their country. This is important, as it goes directly against the argument that more resources and energy will be needed for people in the global south to escape extreme poverty. The biggest factor is the switch from traditional cooking fuels, like firewood or charcoal, to more efficient (and less polluting) electricity and gas.

In Zambia, Nepal, and Vietnam, modern energy resources are extremely unfairly distributed -- more so than income, general spending, or even spending on leisure. As a consequence, poorer households use more dirty energy than richer households, with ensuing health and gender impacts. Cooking with inefficient fuels consumes a lot of energy, and even more when water needs to be boiled before drinking. But do households with higher incomes and more devices have a better chance of escaping poverty? Some do, but having higher incomes and mobile phones are not either prerequisites or guarantees of having basic needs satisfied. Richer households without access to electricity or sanitation are not spared from having malnourished children or health problems from using charcoal. Ironically, for most households, it is easier to obtain a mobile phone than a clean, nonpolluting fuel for cooking. Therefore, measuring progress via household income leads to an incomplete understanding of poverty and its deprivations.

So what? Are we arguing against the global south using more energy for development? No: instead of focusing on how much energy is used, we are pointing to the importance of collective services (like electricity, indoor sanitation and public transport) for alleviating the multiple deprivations of poverty. In addressing these issues we cannot shy away from asking why so many countries in the global south have such a low capacity to invest in those services. It has to do with the fact that poverty does not just happen: it is created via interlinked systems of wealth extraction such as structural adjustment, or high costs of servicing national debts. Given that climate change is caused by the energy use of a rich minority in the global north but the consequences are borne by the majority in the poorer global south, human development is not only a matter of economic justice but also climate justice. Investing in vital collective services underpins both.

United States

FDA Approves Alzheimer's Drug Despite Fierce Debate Over Whether It Works (nytimes.com) 90

The Food and Drug Administration on Monday approved the first new medication for Alzheimer's disease in nearly two decades, a contentious decision, made despite opposition from the agency's independent advisory committee and some Alzheimer's experts who said there was not enough evidence that the drug can help patients. From a report: The drug, aducanumab, which will go by the brand name Aduhelm, is a monthly intravenous infusion intended to slow cognitive decline in people with mild memory and thinking problems. It is the first approved treatment to attack the disease process of Alzheimer's instead of just addressing dementia symptoms. Recognizing that clinical trials of the drug had provided incomplete evidence to demonstrate effectiveness, the F.D.A. granted approval on the condition that the manufacturer, Biogen, conduct a new clinical trial. During the several years it could take for that trial to be concluded, the drug will be available to patients, the agency said. If the post-market study, called a Phase 4 trial, fails to show the drug is effective, the F.D.A. can -- but is not required to -- rescind its approval.
Space

Jeff Bezos Plans to Travel to Space on Blue Origin Flight (bloomberg.com) 131

Jeff Bezos will go to space next month when his company, Blue Origin, launches its first passenger-carrying mission. From a report: The 57-year-old, who plans to travel alongside his brother, Mark, made the announcement in an Instagram post Monday. The scheduled launch next month will be about two weeks after the billionaire plans to step down as chief executive officer of Amazon.com. "Ever since I was five years old, I've dreamed of traveling to space," Bezos said in the post. "On July 20th, I will take that journey with my brother. The greatest adventure, with my best friend."

Blue Origin is one of several high-profile space-tourism companies backed by a wealthy entrepreneur, alongside Elon Musk's Space Exploration Technologies and Richard Branson-backed Virgin Galactic Holdings. Both of those companies are making plans to carry paying customers. Blue Origin is auctioning off a seat on its New Shepard rocket for the July 20 flight, an 11-minute trip to suborbital space that will reach an altitude of about 100 kilometers (62 miles). The spot will be the only one available for purchase on the flight, and the proceeds will go to a Blue Origin foundation that promotes math and science education.

Space

Will the US Air Force Use SpaceX's Starship for Speedy Cargo Deliveries? (arstechnica.com) 133

The U.S. Air Force wants to invest $38 million next year in projects under the heading "Rocket Cargo." Ars Technica reports that Air Force is already spending $9.7 million on the projects, "but seeks to increase that total for the coming year as it moves into the test phase of the program. The funds will have to be approved by Congress as part of its budget deliberation process this summer and fall."

The Air Force's 462-page budget-justifying document says their branch of the military "seeks to leverage the current multi-billion dollar commercial investment to develop the largest rockets ever, and with full reusability to develop and test the capability to leverage a commercial rocket to deliver Air Force cargo anywhere on the Earth in less than one hour, with a 100-ton capacity."

Although this does not refer to Starship by name, this is the only vehicle under development in the world with this kind of capability. The Air Force does not intend to invest directly into the vehicle's development, the document says. However, it proposes to fund science and technology needed to interface with the Starship vehicle so that the Air Force might leverage its capabilities. Clearly, some Air Force officials are intrigued by the possibility of launching 100 tons of cargo from the United States and having the ability to land it anywhere in the world about an hour later.
Medicine

A New Type Of COVID-19 Vaccine Could Debut Soon (npr.org) 148

"A new kind of COVID-19 vaccine could be available as soon as this summer," reports NPR: It's what's known as a protein subunit vaccine. It works somewhat differently from the current crop of vaccines authorized for use in the U.S. but is based on a well-understood technology and doesn't require special refrigeration.

In general, vaccines work by showing people's immune systems something that looks like the virus but really isn't. Consider it an advance warning; if the real virus ever turns up, the immune system is ready to try to squelch it. In the case of the coronavirus, that "something" is one of the proteins in the virus — the spike protein. The vaccines made by Johnson & Johnson, Moderna and Pfizer contain genetic instructions for the spike protein, and it's up to the cells in our bodies to make the protein itself.

The first protein subunit COVID-19 vaccine to become available will likely come from the biotech company, Novavax. In contrast to the three vaccines already authorized in the U.S., it contains the spike protein itself — no need to make it, it's already made — along with an adjuvant that enhances the immune system's response, to make the vaccine even more protective.

Protein subunit vaccines made this way have been around for a while. There are vaccines on the market for hepatitis B and pertussis based on this technology.

And meanwhile, the article points out, there's also another company — the pharmaceutical giant Sanofi — that's also working on its own protein subunit vaccine against the coronavirus.
Cellphones

Apple's MagSafe Devices May Affect Pacemakers (appleinsider.com) 15

The American Heart Association is a research-funding nonprofit. One of its publications, The Journal of the American Heart Association, "has concurred with a previous report by the Heart Rhythm Journal which said close contact with an iPhone 12 affected certain implantable cardiac devices," writes Apple Insider. As with that report, the American Heart Association says the effect are solely when the iPhone is on or very near the implant... "Our study demonstrates that magnet reversion mode may be triggered when the iPhone 12 Pro Max is placed directly on the skin over an implantable cardiac device and thus has the potential to inhibit lifesaving therapies," say the report writers in the Journal of the American Heart Association. The testing involved placing the iPhone 12 Pro Max in very close proximity to a series of 11 different pacemakers and defibrillators... The degree of interference did vary across the testing, but all devices were affected. The report says that "the iPhone 12 Pro Max was able to trigger magnetic reversion mode at a distance up to 1.5cm [0.6 inches]."

"Apple Inc, has an advisory stating that the newer generation iPhone 12 does not pose a greater risk for magnet interference when compared to the older generation iPhones," notes the report. "However, our study suggests otherwise as magnet response was demonstrated in 3/3 cases in vivo..."

In January 2021, Apple updated its MagSafe support document to recommend that users keep the iPhone 12 six inches away from any medical implants.

Medicine

Proven Against Coronavirus, mRNA Can Do So Much More (cnn.com) 108

A long read in Wired argues that the mRNA vaccine revolution is just beginning.

CNN explains why scientists are so excited: When the final Phase 3 data came out last November showing the mRNA vaccines made by Pfizer/BioNTech and Moderna were more than 90% effective, Dr. Anthony Fauci had no words. He texted smiley face emojis to a journalist seeking his reaction. This astonishing efficacy has held up in real-world studies in the U.S., Israel and elsewhere. The mRNA technology developed for its speed and flexibility as opposed to expectations it would provide strong protection against an infectious disease has pleased and astonished even those who already advocated for it...

This approach that led to remarkably safe and effective vaccines against a new virus is also showing promise against old enemies such as HIV, and infections that threaten babies and young children, such as respiratory syncytial virus and metapneumovirus. It's being tested as a treatment for cancers, including melanoma and brain tumors. It might offer a new way to treat autoimmune diseases. And it's also being checked out as a possible alternative to gene therapy for intractable conditions such as sickle cell disease.

In fact, Moderna is already working on personalized cancer vaccines, the article points out — and that's just the beginning. Two researchers whose technology underlies both the Modern and BioNTech/Pfizer vaccines are now also working on two vaccines against HIV, another one to prevent genital herpes, and two targeting influenza, including a so-called universal influenza vaccine that could protect against rapidly mutating flu strains, possibly offering years of protection with a single shot.

And researchers have also studied mRNA vaccines to fight Ebola, Zika, rabies and cytomegalovirus.
Businesses

How Amazon Became an Engine For Anti-Vaccine Misinformation (fastcompany.com) 191

Type "vaccines" into Amazon's search bar, and its auto-complete suggests "are dangerous" for your search. But that's just part of a larger problem, points out Fast Company (in an article shared by Slashdot reader tedlistens).

For example, Amazon's search results are touting as "best sellers!" many books with some very bad science: Offered by small publishers or self-published through Amazon's platform, the books rehearse the falsehoods and conspiracy theories that fuel vaccine opposition, steepening the impact of the pandemic and slowing a global recovery. They also illustrate how the world's biggest store has become a megaphone for anti-vaccine activists, medical misinformers, and conspiracy theorists, pushing dangerous falsehoods in a medium that carries more apparent legitimacy than just a tweet.

"Without question, Amazon is one of the greatest single promoters of anti-vaccine disinformation, and the world leader in pushing fake anti-vaccine and COVID-19 conspiracy books," says Peter Hotez, a pediatrician and vaccine expert at the Baylor College of Medicine. For years, journalists and researchers have warned of the ways fraudsters, extremists, and conspiracy theorists use Amazon to earn cash and attention. To Hotez, who has devoted much of his career to educating the public about vaccines, the real-world consequences aren't academic. In the U.S. and elsewhere, he says, vaccination efforts are now up against a growing ecosystem of activist groups, foreign manipulators, and digital influencers who "peddle fake books on Amazon...."

Gradually, Amazon has taken a tougher approach to content moderation, and to a seemingly ceaseless onslaught of counterfeits, fraud, defective products, and toxic speech... Despite its sweeps, however, Amazon is still flooded with misinformation, and helping amplify it too: A series of recent studies and a review by Fast Company show the bookstore is boosting misinformation around health-related terms like "autism" or "covid," and nudging customers toward a universe of other conspiracy theory books.

In one audit first published in January, researchers at the University of Washington surveyed Amazon's search results for four dozen terms related to vaccines. Among 38,000 search results and over 16,000 recommendations, they counted nearly 5,000 unique products containing misinformation, or 10.47% of the total. For books, they found that titles deemed misinformative appeared higher in search results than books that debunked their theories. "Overall, our audits suggest that Amazon has a severe vaccine/health misinformation problem exacerbated by its search and recommendation algorithms," write Prerna Juneja and Tanushee Mitra in their paper, presented last month at the CHI Conference on Human Factors in Computing Systems. "Just a single click on an anti-vaccine book could fill your homepage with several other similar anti-vaccine books..." Like any products on Amazon, or any content across social media platforms, anti-vaccine titles also benefit from an algorithmically-powered ranking system. And despite the company's aggressive efforts to battle fraud, it's a system that's still easily manipulated through false reviews...

Much of the uproar about misinformation has focused on Facebook, YouTube, and Twitter, but Amazon's role deserves more attention, says Marc Tuters, an assistant professor of new media at the University of Amsterdam, who helped lead the Infodemic.eu study. The retailer sells half of all the books in the U.S. and its brand is highly trusted by consumers.

Social Networks

'TikTok Detected My ADHD Before I Did' (theguardian.com) 94

"It's kind of embarrassing to say, but the social media app TikTok figured out I had ADHD before I did," writes 23-year-old Australian journalist Matilda Boseley in The Guardian.

"For 23 years my parents, my teachers, my doctor, my psychologist and my own brain all missed the warning signs, yet somehow it only took that app's algorithm a few days to accidentally diagnose me..." Growing up I had always had a nagging feeling that everyone else in the world was coping better than I was. Somehow they could remember appointments and deadlines, they had the discipline to keep an updated planner and they didn't drift off daydreaming in the middle of important conversations... I just felt like there were 10 TVs constantly switched on in my head, and with so much going on, all the small things would fall through the cracks. It wasn't until I downloaded TikTok that I truly considered I might have the disorder.

See, the app is based around the "for you" page which curates a stream of videos for you. It starts out pretty generic, but as you "like" some videos, and quickly scroll past others, the app's algorithm builds a profile of you and your interests. And that profile is scarily accurate sometimes. It genuinely knew me better than I knew myself. What I think happened is that the algorithm noticed that every time a video titled something like "Five little known signs of ADHD in women" showed up on my feed I would watch it, fascinated, all the way to the end.

So, like the dystopian capitalism machine it is, the app showed me more and more of these videos desperate to keep me on the app and extract every possible advertising cent my eyeballs could buy. But, as a side effect, all of a sudden I was seeing ADHD content made by women and for women, for the very first time. It was like someone putting everything that always felt weird in my brain into words. Forgetting something exists if you can't see it could be a problem with "object permanence". Being unable to stand up and tidy my apartment, despite desperately wanting to, might not be laziness; it could be "executive dysfunction". Suddenly it occurred to me, maybe I wasn't somehow just "worse at being a person" than everyone else. Maybe I simply didn't have enough dopamine in my brain. I can't overstate how liberating that felt.

So I booked a doctor's appointment, and three referrals, four months and about $700 later my new psychiatrist looked straight into the webcam and said: "Yes, I think you clearly have ADHD and you've had it for your whole life." I cried from joy when he said it.

Mental health experts told me it wasn't actually that surprising that hearing first-hand accounts of neurodivergence is what finally made the pin drop. In fact, Beyond Blue's lead clinical advisor Dr Grant Blashki said social media could be an extraordinarily powerful tool for increasing what the medical community refer to as "mental health literacy". In fact "learning you have ADHD on TikTok" is now such a common phenomenon that it's become its own meme on the app. There isn't any hard and fast data on the phenomenon but just from my own experience, since telling my friends about my diagnosis, no less than four people have come back to me saying they reckon they might have it too...

At the end of the day I am so grateful for TikTok, and the creators that make ADHD videos. That algorithm has profoundly changed my life, undoubtedly for the better.

Earth

Giant Diamonds May Hold the Key To Superdeep Earthquakes (sciencemag.org) 11

"Earthquakes shouldn't occur more than 300 kilometers below Earth's surface, according to most geophysical models," reports Science magazine. "Yet they commonly do — a phenomenon that has mystified seismologists for decades."

Slashdot reader sciencehabit shares their report on one possible explanation: that water carried by the tectonic plates shoved beneath continents "could be triggering these deep temblors." The find may also explain another marvel: why a huge number of fist-size diamonds form at this depth...

Steven Shirey, a geochemist at the Carnegie Institution for Science...and his team took a closer look at how water might make its way down deep... Regardless of depth, Shirey and his team found that once rocks in the slabs reached temperatures above 580 degrees C, they were less able to hold water. As that water flooded out of the slab, it weakened the surrounding rocks and triggered quakes, Shirey and his colleagues report in AGU Advances. This water, typically chock-full of dissolved minerals, would also be available to fuel diamond formation...

"The temperature tells the story," says Douglas Wiens, a seismologist at Washington University in St. Louis who was not involved in the new study. If the tectonic slab starts out hot, as it would if the rocks are relatively young, he says, the plate will dehydrate at depths between 100 and 250 kilometers and thus won't carry water far enough down to generate deep quakes. But if rocks in the sinking slab are old and relatively cool, water will stay locked inside the sinking slab for a longer time, persisting there until it is released at depths of 300 to 500 kilometers or more.

Further work in both the lab and the field will be needed to fully understand the relationships between water released from sinking slabs and deep earthquakes, Wiens says. In the meantime, he says, it's clear that diamonds that form at those depths, imperfections and all, will be critical to teasing out the details of the story.

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