A biotechnology firm has released genetically modified mosquitoes into the United States for the first time. Long-time Slashdot reader clovis shares the report via Nature: The experiment, launched this week in the Florida Keys -- over the objections of some local critics -- tests a method for suppressing populations of wild Aedes aegypti mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever. [...] Aedes aegypti makes up about 4% of the mosquito population in the Keys, a chain of tropical islands off the southern tip of Florida. But it is responsible for practically all mosquito-borne disease transmitted to humans in the region, according to the Florida Keys Mosquito Control District (FKMCD), which is working closely with Oxitec on the project. [...] In late April of this year, project researchers placed boxes containing Oxitec's mosquito eggs at six locations in three areas of the Keys. The first males are expected to emerge within the first two weeks of May. About 12,000 males will exit the boxes each week over the next 12 weeks. In a second phase later this year, intended to collect even more data, nearly 20 million mosquitoes will emerge over a period of about 16 weeks, according to Oxitec. "There is the usual opposition of the 'It's GMO, so it should not be done' variety," adds clovis. "As for ecological food chain considerations, one should know that aedes aegypti is not native to the western hemisphere. It is believed to have been imported from Africa during the slave trade era."

sciencehabit shares a report from Science Magazine: When humans first set foot in Australia more than 65,000 years ago, they faced the perilous task of navigating a landscape they'd never seen. Now, researchers have used supercomputers to simulate 125 billion possible travel routes and reconstruct the most likely "superhighways" these ancient immigrants used as they spread across the continent. The project offers new insight into how landmarks and water supplies shape human migrations, and provides archaeologists with clues for where to look for undiscovered ancient settlements.

It took weeks to run the complex simulations on a supercomputer operated by the U.S. government. But the number crunching ultimately revealed a network of "optimal superhighways" that had the most attractive combinations of easy walking, water, and landmarks. Optimal road map in hand, the researchers faced a fundamental question, says lead author Stefani Crabtree, an archaeologist at Utah State University, Logan, and the Santa Fe Institute: Was there any evidence that real people had once used these computer-identified corridors? To find out, the researchers compared their routes to the locations of the roughly three dozen archaeological sites in Australia known to be at least 35,000 years old. Many sites sat on or near the superhighways. Some corridors also coincided with ancient trade routes known from indigenous oral histories, or aligned with genetic and linguistic studies used to trace early human migrations. "I think all of us were surprised by the goodness of the fit," says archaeologist Sean Ulm of James Cook University, Cairns.

The map has also highlighted little-studied migration corridors that could yield future archaeological discoveries. For example, some early superhighways sat on coastal lands that are now submerged, giving marine researchers a guide for exploration. Even more intriguing, the authors and others say, are major routes that cut across several arid areas in Australia's center and in the northeastern state of Queensland. Those paths challenge a "long-standing view that the earliest people avoided the deserts," Ulm says. The Queensland highway, in particular, presents "an excellent focus point" for future archaeological surveys, says archaeologist Shimona Kealy of the Australian National University. The study has been published in the journal Nature Human Behavior.

Hmmmmmm shares a report from SpaceNews: The Long March 5B, a variant of China's largest rocket, successfully launched the 22.5-metric-ton Tianhe module from Wenchang Thursday local time. Tianhe separated from the core stage of the launcher after 492 seconds of flight, directly entering its planned initial orbit. Designed specifically to launch space station modules into low Earth orbit, the Long March 5B uniquely uses a core stage and four side boosters to place its payload directly into low Earth orbit. However this core stage is now also in orbit and is likely to make an uncontrolled reentry over the next days or week as growing interaction with the atmosphere drags it to Earth. If so, it will be one of the largest instances of uncontrolled reentry of a spacecraft and could potentially land on an inhabited area.

The high speed of the rocket body means it orbits the Earth roughly every 90 minutes and so a change of just a few minutes in reentry time results in reentry point thousands of kilometers away. The Long March 5B core stage's orbital inclination of 41.5 degrees means the rocket body passes a little farther north than New York, Madrid and Beijing and as far south as southern Chile and Wellington, New Zealand, and could make its reentry at any point within this area. The most likely event will see any debris surviving the intense heat of reentry falling into the oceans or uninhabited areas, but the risk remains of damage to people or property.

Curbs on the sale of house coal and wet wood for household burning in England have come into force under new rules aimed at cutting air pollution. From a report: People will still be able to use stoves and open fires but they will need to burn cleaner alternatives. These are the first restrictions on what people can burn in their homes since the clean air acts of the 1950s. The UK's air is far cleaner now, but in recent years pollution from log burners has increased dramatically. Only 8% of households use them, but they are now the biggest source of the tiny pollution particles that are most damaging to health, according to government data. It shows domestic wood burning in both closed stoves and open fires was responsible for 38% of pollution particles under 2.5 microns in size, three times more than road traffic. These tiny particles can enter the bloodstream and lodge in lungs and other organs, the Department for Environment Food and Rural Affairs (Defra) warns, and have been identified by the World Health Organization as the most serious air pollutant for human health.

An anonymous reader quotes a report from the BBC: The world's biggest jeweller, Pandora, says it will no longer sell mined diamonds and will switch to exclusively laboratory-made diamonds. Concerns about the environment and working practices in the mining industry have led to growing demand for alternatives to mined diamonds. Pandora's chief executive, Alexander Lacik, told the BBC the change was part of a broader sustainability drive. He said the firm was pursuing it because "it's the right thing to do." They are also cheaper: "We can essentially create the same outcome as nature has created, but at a very, very different price." Mr Lacik explains they can be made for as little as "a third of what it is for something that we've dug up from the ground."

Pandora's lab-made diamonds are being made in Britain, and the UK is the first country where they will be sold. The new diamond jewelry will start at $350. [...] One problem with lab-made diamonds, though, is that they can take a lot of energy to produce. Between 50% and 60% of them come from China, where they are made in a process known as "high-pressure, high-temperature technology." The use of coal powered electricity is widespread. However in the United States, the biggest retail market for lab-grown diamonds, there is a greater focus on using renewable energy. The largest US producer, Diamond Foundry, says its process is "100% hydro-powered, meaning zero emissions." Both types are chemically and physically identical to mined diamonds.

DesertNomad writes: A dull, dark, otherwise unremarkable spot near the constellation Canis Major appears to be the locus of extra-galactic, super-high-energy cosmic ray production, with the actual source in the Virgo cluster and the cosmic rays' paths distorted by the complex galactic magnetic field. Astrophysicists crafted the most state-of-the-art model of the Milky Way's magnetic field, and found that this model explains the significant change in direction of the cosmic rays. The findings appear in a paper via arXiv.

The Apple Watch may gain the ability to measure blood pressure, blood glucose, and blood alcohol levels, according to newly-revealed information about one of Apple's chosen business partners. MacRumors reports: Apple has been revealed to be the largest customer of the British electronics start-up Rockley Photonics, The Telegraph reports. Rockley Photonics has developed non-invasive optical sensors for detecting multiple blood-related health metrics, including blood pressure, blood glucose, and blood alcohol levels, many of which are only normally detectable with more invasive dedicated medical equipment. Rockley's sensors beam infrared light through a user's skin, much like the existing sensors on the back of the Apple Watch for detecting heart rate and blood oxygen levels.

Rockley's disclosure that its biggest client is Apple came about as the company prepares to go public in New York. The company's filings said that Apple accounted for the majority of its revenue over the last two years and that it has an ongoing "supply and development agreement" with the company, under which it expects to continue to heavily rely on Apple for most of its revenue. Given the growth of Rockley Photonics and the scale of Apple's partnership with the company, it seems to be virtually inevitable that the company's health sensor technology will be coming to the Apple Watch sooner rather than later.

According to The Byte, the co-founder of brain implant startup Neuralink, Max Hodak, announced he's leaving the company. From the report: Hodak, who started the ultra-ambitious venture with Elon Musk and had until recently served as its president, didn't say why he was leaving the company or on what terms. In other words, it's not currently clear whether he left voluntary or was fired. "I am no longer at Neuralink (as of a few weeks ago)," he wrote in a tweet. "I learned a ton there and remain a huge cheerleader for the company! Onward to new things." Last month, Hodak made headlines when he tweeted that the startup has the technological advances and savvy to create its own "Jurassic Park."

An anonymous reader quotes a report from New Atlas: A fascinating new study from a team of US researchers has used machine learning techniques to develop algorithms that can analyze naturalistic driving data and detect mild cognitive impairment and dementia in a driver. The work is still in the preliminary stages, however, the researchers claim it could be possible in the future to detect early signs of dementia using either a smartphone app or devices incorporated into car software systems. The research utilized data from a novel long-term study called LongROAD (The Longitudinal Research on Aging Drivers), which tracked nearly 3,000 older drivers for up to four years, offering a large longitudinal dataset.

Over the course of the LongROAD study, 33 subjects were diagnosed with MCI and 31 with dementia. A series of machine learning models were trained on the LongROAD data, tasked with detecting MCI and dementia from driving behaviors. "Based on variables derived from the naturalistic driving data and basic demographic characteristics, such as age, sex, race/ethnicity and education level, we could predict mild cognitive impairment and dementia with 88 percent accuracy," says Sharon Di, lead author on the new study. Although age was the number one factor for detecting MCI or dementia, a number of driving variables closely followed. These include, "the percentage of trips traveled within 15 miles (24 km) of home ... the length of trips starting and ending at home, minutes per trip, and number of hard braking events with deceleration rates 0.35 g." Using driving variables alone, the models could still predict those MCI or dementia drivers with 66 percent accuracy. The new study was published in the journal Geriatrics.

It's taken 17 years, with many setbacks and some deaths, and still Richard Branson's space mission is yet to launch. From a report: Richard Branson was running almost 15 years late. But as we rode into the Mojave desert on the morning of 12 December 2018, he was feeling upbeat and untroubled by the past. He wore jeans, a leather jacket and the easy smile of someone used to being behind schedule. Branson hadn't exactly squandered the past 15 years. He'd become a grandfather, moved to a private island in the Caribbean and expanded Virgin's business empire into banking, hotels, gyms, wedding dresses and more. But he was staking his legacy on Virgin Galactic, the space tourism company he formed in 2004. The idea was to build a rocketship with seats for eight -- two pilots, six passengers -- that would be carried aloft by a mothership, released about 45,000ft in the air and then zoom just beyond the lower limit of space, float around for a few minutes, before returning to Earth. He was charging $200,000 a seat. It did not initially seem like such a crazy idea. That year, a boutique aviation firm in Mojave, California, two hours north of Los Angeles, had built a prototype mothership and rocketship that a pair of test pilots flew to space three times, becoming the first privately built space craft. Branson hired the firm to design, build and test him a bigger version of the craft.

But the undertaking was proving far more difficult than Branson anticipated. An accidental explosion in 2007 killed three engineers. A mid-air accident in 2014 destroyed the ship and killed a test pilot, forcing Virgin Galactic to more or less start over. I approached the company shortly after the accident to ask if I could embed with them and write a story about their space programme for the New Yorker. I worked on the story for four years. After it came out, in August 2018, I spent another two years reporting and writing a book about the test pilots who fly Branson's spaceship. Amid the tragedies and setbacks, Branson remained optimistic of the prospect of imminent success. In 2004: "It is envisaged that Virgin Galactic will open for business by the beginning of 2005 and, subject to the necessary safety and regulatory approvals, begin operating flights from 2007." Then, in 2009: "I'm very confident that we should be able to meet 2011." Later, in 2017: "We are hopefully about three months before we are in space, maybe six months before I'm in space." Meanwhile, other private space companies, such as Elon Musk's SpaceX and Jeff Bezos's Blue Origin, were making progress. Branson confessed that had he known in 2004 what he knew now, "I wouldn't have gone ahead with the project... We simply couldn't afford it."

His record on delivering promises has made him a polarising figure. Branson has appeared on lists of both hucksters and heroes. One poll ranked him second among people whom British children should emulate; Jesus Christ came third. His biographer describes him as "a card player with a weak hand who plays to strength," but also a "self-made and self-deprecating man whose flamboyance endears him to aspiring tycoons, who snap up his books and flock to his lectures to glean the secrets of fortune-hunting." But all of that was in the past; the turmoil and hardship would hopefully make the triumph all that much sweeter. For he and I knew as we headed into the desert that tomorrow could finally be the day that Virgin Galactic went to space.

Widely circulating coronavirus variants and persistent hesitancy about vaccines will keep the goal out of reach. The virus is here to stay, but vaccinating the most vulnerable may be enough to restore normalcy. From a report: Early in the pandemic, when vaccines for the coronavirus were still just a glimmer on the horizon, the term "herd immunity" came to signify the endgame: the point when enough Americans would be protected from the virus so we could be rid of the pathogen and reclaim our lives. Now, more than half of adults in the United States have been inoculated with at least one dose of a vaccine. But daily vaccination rates are slipping, and there is widespread consensus among scientists and public health experts that the herd immunity threshold is not attainable -- at least not in the foreseeable future, and perhaps not ever. Instead, they are coming to the conclusion that rather than making a long-promised exit, the virus will most likely become a manageable threat that will continue to circulate in the United States for years to come, still causing hospitalizations and deaths but in much smaller numbers.

How much smaller is uncertain and depends in part on how much of the nation, and the world, becomes vaccinated and how the coronavirus evolves. It is already clear, however, that the virus is changing too quickly, new variants are spreading too easily and vaccination is proceeding too slowly for herd immunity to be within reach anytime soon. Continued immunizations, especially for people at highest risk because of age, exposure or health status, will be crucial to limiting the severity of outbreaks, if not their frequency, experts believe. "The virus is unlikely to go away," said Rustom Antia, an evolutionary biologist at Emory University in Atlanta. "But we want to do all we can to check that it's likely to become a mild infection." The shift in outlook presents a new challenge for public health authorities. The drive for herd immunity -- by the summer, some experts once thought possible -- captured the imagination of large segments of the public. To say the goal will not be attained adds another "why bother" to the list of reasons that vaccine skeptics use to avoid being inoculated. Yet vaccinations remain the key to transforming the virus into a controllable threat, experts said. Dr. Anthony S. Fauci, the Biden administration's top adviser on Covid-19, acknowledged the shift in experts' thinking. "People were getting confused and thinking you're never going to get the infections down until you reach this mystical level of herd immunity, whatever that number is," he said.

Four astronauts in a SpaceX Dragon capsule successfully splashed down into the Gulf of Mexico this morning at 2:57 a.m. ET — returning from the International Space Station in the first U.S. crew splashdown in darkness since the Apollo 8 moonshot in 1968.

Phys.org reports: It was an express trip home, lasting just 6 1/2 hours... "We welcome you back to planet Earth and thanks for flying SpaceX," SpaceX's Mission Control radioed moments after splashdown. "For those of you enrolled in our frequent flyer program, you've earned 68 million miles on this voyage...."

The 167-day mission was the longest for a crew capsule launching from the U.S. The previous record of 84 days was set by NASA's final Skylab station astronauts in 1974. Saturday night's undocking left seven people at the space station, four of whom arrived a week ago via SpaceX...

Once finished with their medical checks on the ship, the astronauts planned to hop on a helicopter for the short flight to shore, then catch a plane straight to Houston for a reunion with their families. "It's not very often you get to wake up on the space station and go to sleep in Houston," chief flight director Holly Ridings told reporters.

The astronauts' capsule, Resilience, will head back to Cape Canaveral for refurbishment for SpaceX's first private crew mission in September... A tech billionaire has purchased the entire three-day flight, which will orbit 75 miles (120 kilometers) above the space station. He'll fly with a pair of contest winners and a physician assistant from St. Jude Children's Research Hospital, his designated charity for the mission.

SpaceX's next astronaut launch for NASA will follow in October.

Scientific American has published an opinion piece by the principle investigator for a project called SPARK, launched five years ago "to harness the power of big data by engaging hundreds of thousands of individuals with autism and their family members to participate in research."

The article calls autism "a remarkably heterogeneous disorder that affects more than five million Americans and has no FDA-approved treatments," arguing that the more people who participate in their research, "the deeper and richer these data sets become, catalyzing research that is expanding our knowledge of both biology and behavior to develop more precise approaches to medical and behavioral issues." SPARK is the world's largest autism research study to date with over 250,000 participants, more than 100,000 of whom have provided DNA samples through the simple act of spitting in a tube. We have generated genomic data that have been de-identified and made available to qualified researchers. SPARK has itself been able to analyze 19,000 genes to find possible connections to autism; worked with 31 of the nation's leading medical schools and autism research centers; and helped thousands of participating families enroll in nearly 100 additional autism research studies.

Genetic research has taught us that what we commonly call autism is actually a spectrum of hundreds of conditions that vary widely among adults and children. Across this spectrum, individuals share core symptoms and challenges with social interaction, restricted interests and/or repetitive behaviors. We now know that genes play a central role in the causes of these "autisms," which are the result of genetic changes in combination with other causes including prenatal factors. To date, research employing data science and machine learning has identified approximately 150 genes related to autism, but suggests there may be as many as 500 or more...

But in order to get answers faster and be certain of these results, SPARK and our research partners need a huge sample size: "bigger data." To ensure an accurate inventory of all the major genetic contributors, and learn if and how different genetic variants contribute to autistic behaviors, we need not only the largest but also the most diverse group of participants. The genetic, medical and behavioral data SPARK collects from people with autism and their families is rich in detail and can be leveraged by many different investigators. Access to rich data sets draws talented scientists to the field of autism science to develop new methods of finding patterns in the data, better predicting associated behavioral and medical issues, and, perhaps, identifying more effective supports and treatments...

We know that big data, with each person representing their unique profile of someone impacted by autism, will lead to many of the answers we seek.

"Scientists have spotted one of the largest stellar flares ever recorded in our galaxy," reports Space.com: The jets of plasma shot outward from the sun's nearest neighbor, the red dwarf star Proxima Centauri. The flare, which was around 100 times more powerful than any experienced in our solar system, could change the way scientists think about solar radiation and alien life...

On May 1, 2019, the team captured the mega flare, which shone for just 7 seconds and was mainly visible in the ultraviolet spectrum. "The star went from normal to 14,000 times brighter when seen in ultraviolet wavelengths over the span of a few seconds," lead author Meredith MacGregor, an astrophysicist at the University of Colorado Boulder, said in a statement...

The flare on Proxima Centauri was extremely powerful compared with those emitted by the sun. Unlike flares from the sun, this one also emitted different kinds of radiation. In particular, it produced a huge surge of ultraviolet light and radio waves — known as "millimeter radiation...." The new findings suggest that stellar flares given off by red dwarfs are much more violent than previously expected and could reduce the likelihood of alien life developing around them.
Proxima Centauri is orbited by two explanets, one of which "is considered to be Earth-like and lies within the star's habitable zone — the distance from a star that could support the development of life, according to the researchers..."

But in a statement, the leader authors now points out that Proxima Centauri's planets "are getting hit by something like this not once in a century, but at least once a day, if not several times a day."

NASA has suspended work on SpaceX's new $2.9 billion lunar lander contract while a federal watchdog agency adjudicates two protests over the award, the agency said Friday. The Verge reports: Putting the Human Landing System (or HLS) work on hold until the GAO makes a decision on the two protests means SpaceX won't immediately receive its first chunk of the $2.9 billion award, nor will it commence the initial talks with NASA that would normally take place at the onset of a major contract. Elon Musk's SpaceX was picked by NASA on April 16th to build the agency's first human lunar lander since the Apollo program, as the agency opted to rely on just one company for a high-profile contract that many in the space industry expected to go to two companies.

As a result, two companies that were in the running for the contract, Blue Origin and Dynetics, protested NASA's decision to the Government Accountability Office, which adjudicates bidding disputes. Blue Origin alleges the agency unfairly "moved the goalposts at the last minute" and endangered NASA's speedy 2024 timeline by only picking SpaceX. "Pursuant to the GAO protests, NASA instructed SpaceX that progress on the HLS contract has been suspended until GAO resolves all outstanding litigation related to this procurement," NASA spokeswoman Monica Witt said in a statement.

NASA's Ingenuity helicopter completed its fourth and most ambitious test flight across Mars on Friday. CNET reports: NASA JPL tweeted "Success," saying Ingenuity went father and faster than ever before. NASA also shared a nifty image from one of the Perseverance rover's cameras showing the helicopter in flight in the distance. Ingenuity had originally been scheduled for a fourth flight on Thursday, but a known glitch prevented the rotorcraft from switching into flight mode. The chopper remained safe and healthy and ready for the redo.

The plan for the latest test was to fly the helicopter to an altitude of 16 feet (5 meters), collect images of the landscape below, hover and then head back to its takeoff spot. The flight path was set to take it 436 feet (133 meters) downrange and last 117 seconds. It takes time to send the data back from Mars, but NASA is expecting to receive a bounty of photos snapped by the helicopter during the flight. This will help prove the rotorcraft's potential for use as a scout that can assist surface vehicles like rovers as they explore from the ground. NASA said the plucky chopper already "has met or surpassed all of its technical objectives." That gave the helicopter team license to try the more daring fourth flight to push its capabilities in the thin atmosphere of Mars.

Astronomers reconstructed a space rock's path before it exploded over southern Africa in 2018 and sprinkled the Kalahari with meteorites. From a report: On the morning of June 2, 2018, an asteroid was seen careening toward us at 38,000 miles per hour. It was going to impact Earth, and there was nothing anyone could do to stop it. Astronomers were beside themselves with excitement. Five feet long and weighing about the same as an adult African elephant, this space rock posed no threat. But the early detection of this asteroid, only the second to be spotted in space before hitting land, was a good test of our ability to spot larger, more dangerous asteroids. Moreover, it afforded scientists the chance to study the asteroid before its obliteration, quickly narrow down the impact site and obtain some of the most pristine, least weathered meteorite samples around. Later that day, a fireball almost as bright as the sun illuminated Botswana's darkened sky before exploding 17 miles above ground with the force of 200 tons of TNT. Fragments fell like extraterrestrial buckshot into a national park larger than the Netherlands.

Immediately, Botswanan scientists and guides joined with international meteorite experts to hunt for the asteroid's wreckage. As of November 2020, the team has found 24 individual meteorites. And thanks to the telltale geology of these rocky leftovers, observations of their path to Earth and the memories of a dead NASA spacecraft, scientists were able to unspool the history of this asteroid with breathtaking detail. As reported earlier this month in the journal Meteoritics & Planetary Science, Botswana's off-world visitor was once part of Vesta, a gigantic ramshackle asteroid forged at the dawn of the solar system. About 22 million years ago, another asteroid crashed into one of its lonely hills, leaving a modest crater and sending countless shards of Vesta on a space odyssey. One of them was the object that fell over southern Africa in 2018, an explosive end to a lonely journey. 'It is such an amazing thing to be in possession of such a rare specimen with so much history attached to it," said Mohutsiwa Gabadirwe, a geologist and curator at the Botswana Geoscience Institute who is a co-author.

Named 2018 LA, the asteroid was first seen by the Catalina Sky Survey, a trio of telescopes north of Tucson, Ariz. Additional telescopes, like the SkyMapper Southern Sky Survey, saw it too, allowing scientists to tentatively map out an impact site in southern Africa. Peter Jenniskens, a meteorite expert at the SETI Institute and study author, said that the initial search area was a 1,400-square-mile patch in Botswana. Hoping to shrink it down, he visited local businesses with Oliver Moses of the Okavango Research Institute. They located security camera footage at a hotel and gas stations that had recorded the fireball, allowing them to more precisely pinpoint the fall site: a (still-sizable) spot within the Central Kalahari Game Reserve. This was a surreal place to go meteorite hunting. Bat-eared foxes and warthogs strolled past, lions stealthily stalked and slaughtered giraffes while leopards lounged in trees. Wardens from Botswana's Department of Wildlife and National Parks protected the search party in case a fanged predator got too close for comfort. The meteorites also looked a lot like animal poop, meaning the team were frequently bamboozled by coprological impostors. 'It was a totally unusual experience for all of us,' said Mr. Gabadirwe.

An anonymous reader quotes a report from Phys.Org: Scientists from Stony Brook University and the Max Planck Institute of Animal Behavior have pieced together a timeline of how brain and body size evolved in mammals over the last 150 million years. The findings, published in Science Advances, show that brain size relative to body size -- long considered an indicator of animal intelligence -- has not followed a stable scale over evolutionary time. The international team of 22 scientists, including biologists, evolutionary statisticians, and anthropologists, compared the brain mass of 1400 living and extinct mammals. For the 107 fossils examined -- among them ancient whales and the most ancient Old World monkey skull ever found -- they used endocranial volume data from skulls instead of brain mass data. The brain measurements were then analyzed along with body size to compare the scale of brain size to body size over deep evolutionary time.

According to the study, "big-brained" humans, dolphins, and elephants, for example, attained their proportions in different ways. Elephants increased in body size, but surprisingly, even more in brain size. Dolphins, on the other hand, generally decreased their body size while increasing brain size. Great apes showed a wide variety of body sizes, with a general trend towards increases in brain and body size. In comparison, ancestral hominins, which represent the human line, showed a relative decrease in body size and increase in brain size compared to great apes. The authors say that these complex patterns urge a re-evaluation of the deeply rooted paradigm that comparing brain size to body size for any species provides a measure of the species' intelligence. The study has been published in the journal Science Advances.

Artem S. Tashkinov shares a report from Ars Technica: Health regulators in Brazil say that doses of Russia's Sputnik V COVID-19 vaccine contain a cold-causing virus capable of replicating in human cells. The unintended presence of the virus in the vaccine can "lead to infections in humans and can cause damage and death, especially in people with low immunity and respiratory problems, among other health problems," Brazil's Health Regulatory Agency, Anvisa, said Wednesday in a translated statement. Russia has unequivocally denied the claim, lobbed legal threats at Anvisa, and accused the respected regulators of being politically motivated to reject the vaccine. Still, Brazil's findings raise serious questions about the quality and safety of the vaccine, which is now being used in many countries. The findings also support concerns of Slovak regulators, who said earlier this month that batches of Sputnik V they received did not "have the same characteristics and properties" as the Sputnik V vaccine that was described in a peer-reviewed publication and found to be 91.6 percent effective.

Moreover, quality-control issues weren't the end of Anvisa's concerns. In an overall evaluation of the Russian vaccine, Brazil's regulators found its safety and efficacy were based on insufficient, limited, and sometimes faulty data and analyses. "Flaws... were identified in all stages of clinical studies," Anvisa said. The agency also reported that its inspectors who traveled to Russia to assess the vaccine's production were barred from vaccine facilities at Gamaleya Institute, which developed Sputnik V. Russia touts that "the safety and efficacy of Sputnik V has been confirmed by 61 regulators in countries where the vaccine has been authorized." However, Brazil's regulators said that of the 51 countries it contacted, only 14 were using the vaccine, and most of those countries did not have a tradition of vigilant drug-safety monitoring.

An anonymous reader quotes a report from Scientific American: Since the novel coronavirus began its global spread, influenza cases reported to the World Health Organization have dropped to minuscule levels. The reason, epidemiologists think, is that the public health measures taken to keep the coronavirus from spreading also stop the flu. Influenza viruses are transmitted in much the same way as SARS-CoV-2, but they are less effective at jumping from host to host. As Scientific American reported last fall, the drop-off in flu numbers was both swift and universal. Since then, cases have stayed remarkably low. "There's just no flu circulating," says Greg Poland, who has studied the disease at the Mayo Clinic for decades. The U.S. saw about 600 deaths from influenza during the 2020-2021 flu season. In comparison, the Centers for Disease Control and Prevention estimated there were roughly 22,000 deaths in the prior season and 34,000 two seasons ago.

Because each year's flu vaccine is based on strains that have been circulating during the past year, it is unclear how next year's vaccine will fare, should the typical patterns of the disease return. [...] Public health experts are grateful for the reprieve. Some are also worried about a lost immune response, however. If influenza subsides for several years, today's toddlers could miss a chance to have an early-age response imprinted on their immune system. That could be good or bad, depending on what strains circulate during the rest of their life. For now, future flu transmission remains a roll of the dice.