Medicine

Meet Molnupiravir, Merck's Pill That Cuts COVID-19 Hospitalization and Death By About Half (arstechnica.com) 181

An anonymous reader quotes a report from Ars Technica: An oral antiviral drug appears to cut the risk of hospitalization and death from COVID-19 by roughly 50 percent in people newly diagnosed with the infection and at risk for severe disease, pharmaceutical company Merck announced Friday morning. The drug-maker and its partner, Ridgeback Biotherapeutics, released top-line results of a Phase III trial, which the companies ended early given the positive results. The companies say they will apply for an Emergency Use Authorization from the US Food and Drug Administration as soon as possible.

The trial enrolled people who had newly tested positive for a SARS-CoV-2 infection and had onset of mild-to-moderate COVID-19 symptoms within just the past five days of starting the trial. The enrollees also had to have at least one risk factor for a poor outcome, such as having obesity, diabetes, heart disease, or being age 60 or above. While some participants received a placebo and standard care, others took an oral dose of the drug every 12 hours for five days. After 29 days of follow-up, 53 out of 377 participants who received the placebo were hospitalized with COVID-19, and eight of those participants died. Among those who received the drug, only 28 of 385 were hospitalized and none of those patients died. Put another way, 7.3 percent of patients on the drug were either hospitalized or died compared with 14.1 percent in the placebo group. Merck also highlighted that the trial was global and that the drug appeared to work equally well against varying SARS-CoV-2 variants, including delta, gamma, and mu. The drug-maker noted that it had viral genetic data to identify variants from 40 percent of participants. The safety data was equally promising, with participants reporting similar numbers of drug-related adverse events between the placebo group than the drug group (11 percent and 12 percent, respectively). About 3.4 percent of people in the placebo group quit the study due to adverse events, while only 1.3 percent quit in the drug group.

The drug at the center of these seemingly smashing results is dubbed molnupiravir -- a name inspired by that of Thor's hammer, Mjolnir. The idea is that the drug will strike down SARS-CoV-2, like a mighty blow from the god of thunder. In an interview with Stat news, Merck's head of research and development, Dean Li, said that the new data proves the drug's mythological force. "Our prediction from our in vitro studies and now with this data is that molnupiravir is named after the right [thing]... this is a hammer against SARS-CoV-2 regardless of the variant." Molnupiravir is a small molecule that wallops the work of a viral RNA-dependent RNA polymerase, an enzyme critical for making copies of RNA viruses, such as SARS-CoV-2. [...] Molnupiravir delivers a precise blow to viral RNA polymerase by posing as a building block for RNA. In the body, molnupiravir is forged into a deceptive ribonucleoside that the polymerase unwittingly incorporates into new strands of viral RNA instead of cytidine. This is essentially lethal. Researchers call the effect a "viral error catastrophe," in which the rate of genetic mutations or errors exceeds a threshold compatible with the virus surviving.

Censorship

Who Censored Marie Antoinette's Letters? X-Rays Reveal a Surprise (science.org) 26

sciencehabit shares a report from Science.org: In late 1791 and early 1792, on the eve of the French Revolutionary Wars, Queen Marie Antoinette engaged in a secret correspondence with her confidant and rumored lover, Swedish Count Axel von Fersen. Nearly 50 letters from that exchange survive at the French National Archives. But certain passages in 15 of the letters were unreadable, obscured by redactions made with swirls of dark ink. Now, researchers have revealed the words beneath 45 of these alterations using x-ray technology. They have also discovered the censor's identity: von Fersen, himself. The idea that von Fersen made the redactions is "a revelation," says Catriona Seth, a professor of French literature at the University of Oxford who was not involved with the work. Historians had thought the letters were censored in the second half of the 19th century -- most likely by von Fersen's great-nephew -- to protect the writers' reputations. Now, she says, scholars will need to rethink the cover-up -- and the reasons behind it.

The newly legible passages are largely sentimental, phrases like "made my heart happy," and "you that I love." Comments on politics and world events, meanwhile, remain uncensored. But even these seemingly intimate phrases don't definitively tell historians anything new about Marie Antoinette and von Fersen's relationship, Seth says. Scholars, she notes, already knew Marie Antoinette had "a very deep affection for him." Still, she adds, the letters offer "direct insight into the thoughts and feelings of Marie Antoinette." In the future, the techniques in this study could be used in combination with machine algorithms to automatically transcribe old texts, the researchers say, making it easier to understand these important documents -- and others like them.
The researchers published their findings in the journal Science Advances.
Education

California Becomes First State To Require Covid-19 Vaccination For Students 232

skam240 writes: California has just become the first state to add Covid-19 vaccination to its list of required vaccines for in-school attendance. "The requirement will go into effect at the start of the term that follows the FDA's full approval for that grade group -- either January 1 or July 1," reports CNN, citing a release from Gov. Gavin Newsom's office. For grades 7-12 the requirement is expected to begin on July 1, 2022. Newsom's office said independent study is an option for unvaccinated students. "This will accelerate our effort to get this pandemic behind us," Newsom told CNN's Ana Cabrera minutes after making the announcement. "We already mandate 10 vaccines. In so many ways... it's probably the most predictable announcement."

"I have four young kids. I can't take this anymore. I'm like most parents, I want to get this behind us, get this economy moving again, make sure our kids never have to worry about getting a call saying they can't go to school the next day because one of the kids or a staff member tested positive," the governor added.
AI

AI Can Predict If It Will Rain In Two Hours' Time (bbc.com) 50

Artificial intelligence can tell whether it is going to rain in the next two hours, research suggests. The BBC reports: Scientists at Google-owned London AI lab DeepMind and the University of Exeter partnered with the Met Office to build the so-called nowcasting system. Traditional methods use complex equations and often forecast for only between six hours and two weeks' time. The AI system can make more accurate short-term predictions, including for critical storms and floods. The system learned how to identify common patterns of rainfall, using UK radar maps from 2016 to 2018, was tested on maps from 2019 and found, by 50 Met Office meteorologists, to be accurate in 89% of cases. The research, published in the journal Nature, found: "Meteorologists significantly preferred the [AI] approach to competing methods."
Space

Blue Origin Has a Toxic Culture, Former and Current Employees Say (arstechnica.com) 97

An anonymous reader quotes a report from Ars Technica: A former communications executive at Blue Origin and 20 other current and former employees have written a blistering essay about the company's culture, citing safety concerns, sexist attitudes, and a lack of commitment to the planet's future. "In our experience, Blue Origin's culture sits on a foundation that ignores the plight of our planet, turns a blind eye to sexism, is not sufficiently attuned to safety concerns, and silences those who seek to correct wrongs," the essay authors write. "That's not the world we should be creating here on Earth, and certainly not as our springboard to a better one." Published Thursday on the Lioness website, the essay is signed publicly by only Alexandra Abrams, who led employee communications for the company until she was terminated in 2019. The other signatories, a majority of whom were engineers, declined to publicly disclose their names because they did not want to jeopardize employment at Blue Origin or harm their prospects in the aerospace industry for other jobs.

At times, the essay is shocking in its candor. Many of the essay's authors said they would not feel safe flying on a Blue Origin vehicle. And the anecdotes of sexism and an unhealthy work culture are vivid. "Former and current employees have had experiences they could only describe as dehumanizing, and are terrified of the potential consequences for speaking out against the wealthiest man on the planet," the authors write. "Others have experienced periods of suicidal thoughts after having their passion for space manipulated in such a toxic environment. One senior program leader with decades in the aerospace and defense industry said working at Blue Origin was the worst experience of her life."

After publication of the essay, Ars spoke with several current and former employees who have provided reliable information in the past about the company. Although it is clear the essay was a product of disgruntled workers, these sources agreed that there were elements of truth in the essay. For these sources, the withering criticism of Blue Origin founder Jeff Bezos, and his hand-picked chief executive, Bob Smith, rang especially true. The essay authors write, "Professional dissent at Blue Origin is actively stifled. Smith personally told one of us to not make it easy for employees to ask questions at company town halls -- one of the only available forums for live, open discussion." These town halls are typically moderated so that employees cannot directly ask questions of Smith. In one infamous exchange, there were apparently so few substantive questions Smith was willing to answer that the moderator resorted to asking Smith what his favorite ice cream was. "Sorbet," Smith answered. Another example of unwelcome management tactics cited in the essay was Bezos' decision, after the Supreme Court ruling in the Epic Systems arbitration case, to force employees to sign away their right to resolve employment disputes in court. Sources confirmed to Ars that they were indeed faced with the choice of signing such an onerous contract or realizing they would eventually have to leave Blue Origin. It seemed grossly unfair.
In response, Blue Origin said in a statement: "Ms. Abrams was dismissed for cause two years ago after repeated warnings for issues involving federal export control regulations. Blue Origin has no tolerance for discrimination or harassment of any kind. We provide numerous avenues for employees, including a 24/7 anonymous hotline, and will promptly investigate any new claims of misconduct."

Abrams disputes those claims, saying that she never received any warnings, verbal or written, from management issues involving federal export control regulations.
Space

FAA Clears Virgin Galactic's SpaceShipTwo For Flight After Probe Into July Incident (npr.org) 14

Virgin Galactic is cleared to resume flights of its SpaceShipTwo space plane, the Federal Aviation Administration (FAA) said Wednesday, after capping a safety investigation into issues that came up during the company's July flight carrying its founder Richard Branson. During that mission, SpaceShipTwo strayed from its designated airspace on its descent from space, and Virgin Galactic didn't tell the FAA about it when it was supposed to. The Verge reports: With the investigation now closed, the FAA required Virgin Galactic to make changes "on how it communicates to the FAA during flight operations to keep the public safe," it said in a statement. Virgin Galactic said that includes "updated calculations to expand the protected airspace for future flights" and "additional steps into the Company's flight procedures to ensure real-time mission notifications to FAA Air Traffic Control." Another change: "Updated calculations to expand the protected airspace for future flights," the company said. "We appreciate the FAA's thorough review of this inquiry. Our test flight program is specifically designed to continually improve our processes and procedures," Virgin Galactic CEO Michael Colglazier said in a statement. "The updates to our airspace and real-time mission notification protocols will strengthen our preparations as we move closer to the commercial launch of our spaceflight experience."
Science

CRISPR Gene-Editing Experiment Partly Restores Vision In Legally Blind Patients (npr.org) 26

An anonymous reader quotes a report from NPR: Carlene Knight's vision was so bad that she couldn't even maneuver around the call center where she works using her cane. But that's changed as a result of volunteering for a landmark medical experiment. Her vision has improved enough for her to make out doorways, navigate hallways, spot objects and even see colors. Knight is one of seven patients with a rare eye disease who volunteered to let doctors modify their DNA by injecting the revolutionary gene-editing tool CRISPR directly into cells that are still in their bodies. Knight and [another volunteer in the experiment, Michael Kalberer] gave NPR exclusive interviews about their experience. This is the first time researchers worked with CRISPR this way. Earlier experiments had removed cells from patients' bodies, edited them in the lab and then infused the modified cells back into the patients. [...]

CRISPR is already showing promise for treating devastating blood disorders such as sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer. But those experiments involve taking cells out of the body, editing them in the lab, and then infusing them back into patients. That's impossible for diseases like [Leber congenital amaurosis, or LCA], because cells from the retina can't be removed and then put back into the eye. So doctors genetically modified a harmless virus to ferry the CRISPR gene editor and infused billions of the modified viruses into the retinas of Knight's left eye and Kalberer's right eye, as well as one eye of five other patients. The procedure was done on only one eye just in case something went wrong. The doctors hope to treat the patients' other eye after the research is complete. Once the CRISPR was inside the cells of the retinas, the hope was that it would cut out the genetic mutation causing the disease, restoring vision by reactivating the dormant cells.

The procedure didn't work for all of the patients, who have been followed for between three and nine months. The reasons it didn't work might have been because their dose was too low or perhaps because their vision was too damaged. But Kalberer, who got the lowest dose, and one volunteer who got a higher dose, began reporting improvement starting at about four to six weeks after the procedure. Knight and one other patient who received a higher dose improved enough to show improvement on a battery of tests that included navigating a maze. For two others, it's too soon to tell. None of the patients have regained normal vision -- far from it. But the improvements are already making a difference to patients, the researchers say. And no significant side effects have occurred. Many more patients will have to be treated and followed for much longer to make sure the treatment is safe and know just how much this might be helping.

NASA

Blue Origin 'Gambled' With Its Moon Lander Pricing, NASA Says in Legal Documents (theverge.com) 92

Jeff Bezos' Blue Origin "gambled" with its Moon lander proposal last year by hoping NASA would be willing to negotiate its $5.9 billion price tag, agency attorneys argued in blunt legal filings obtained by The Verge. From a report: NASA, cash-strapped with a tight budget from Congress, declined to negotiate and turned down Blue Origin's lunar lander in April and picked SpaceX's instead, sparking ongoing protests from Bezos' space company. NASA officials haven't talked much about Blue Origin's legal quarrels beyond occasional acknowledgements that the company's protesting -- first at a watchdog agency and now in federal court -- is holding up the agency's effort to land humans on the Moon by 2024.

But in hundreds of pages of legal filings The Verge obtained in a Freedom of Information Act request, agency attorneys exhaustively laid out NASA's defense of its Artemis Moon program and doubled down on its decision to pick one company, SpaceX, for the first crewed mission to the lunar surface since 1972. In NASA's main response to Blue Origin's protest, filed in late May, senior agency attorneys accused the company of employing a sort of door-in-the-face bidding tactic with its $5.9 billion proposal for Blue Moon, the lunar lander Blue Origin is building with a "National Team" that includes Lockheed Martin and Northrop Grumman. Blue Origin was "able and willing" to offer NASA a lower price for its lunar lander but chose not to because it expected NASA to ask and negotiate for a lower price first, the attorneys allege, citing a six-page declaration written by the company's senior vice president Brent Sherwood in April.

Science

Gene Editing 'Would Allow Us To Create Hardier Farm Breeds' (theguardian.com) 91

Leading UK researchers, vets and farmers have urged ministers to free livestock science of unnecessary legal curbs as the country prepares, post-Brexit, to ease gene-editing rules. Such a move would allow the creation of new breeds of animals resistant to disease, heat and drought, they argue. From a report: The government is expected to propose easing gene-editing restrictions in the near future to enable the creation of new generations of crops. However, the group -- which has written to the environment secretary, George Eustice -- worries there is less interest in using the technology to create new breeds of pigs, cows and poultry.

"It is every bit as important that we use the enormous power of gene editing to create breeds of animals that are resistant to disease, droughts and heatwaves as it is to fashion new crop varieties," said Professor Bruce Whitelaw of Edinburgh's Roslin Institute. "This is particularly important as global warming intensifies and we strive to ensure we are protected against future outbreaks of zoonotic diseases." The value of gene editing in this latter field is shown by work carried out at Roslin and Imperial College London, where scientists have identified a gene that may confer resistance to influenza. "We can now think about using gene editing to create breeds resistant to avian and swine flu, and so curb outbreaks on farms, while also reducing the risk of triggering future pandemics in humans," added Whitelaw, one of the letter's signatories.

Youtube

YouTube Will Remove Videos With Misinformation About Any Vaccine 549

YouTube will begin removing content questioning any approved medical vaccine, not just those for Covid-19, a departure from the video site's historically hands-off approach. From a report: The division of Alphabet's Google announced Wednesday that it will extend its policy against misinformation to cover all vaccines that health authorities consider effective. The ban will include any media that claims vaccines are dangerous or lead to chronic health outcomes such as autism, said Matt Halprin, YouTube's vice president for trust and safety. A year ago, YouTube banned certain videos critical of Covid-19 vaccines. The company said it has since pulled more than 130,000 videos for violating that rule. But many videos got around the rule by making dubious claims about vaccines without mentioning Covid-19. YouTube determined its policy was too limited. "We can imagine viewers then potentially extrapolating to Covid-19," Halprin said in an interview. "We wanted to make sure that we're covering the whole gamut."
Science

Identical Twins Carry Genetic Modifications No One Else Has (science.org) 17

sciencehabit shares a report from Science.org: Identical twins are living proof of how genetics shapes our looks and traits. Now, researchers have found they carry a molecular signature on their DNA that no one else has -- one that becomes fixed in their cells early in development and stays with them into adulthood. This signature doesn't seem to influence a twin's health, but it could offer insights into how identical twinning happens. "It is a starting point" for solving "what is really an enigma," says Jenny van Dongen, a twin genetics researcher at Free University (VU), Amsterdam. The signature could also be used to test whether a person had a "vanishing twin," an identical twin that died in the womb.

An international team led by van Dongen and VU twin genetics researcher Dorret Boomsma looked for clues in what's known as the epigenome. Patterns of chemical tags called methyl groups glom onto genes, turning them on or off. (Such epigenetic changes are responsible for everything from enabling Peruvians to live at high altitudes to helping the placenta develop.) Using blood and cheek cell samples, the researchers scanned the epigenomes of more than 3000 identical twins, as well as a comparable number of fraternal twins and some twins' parents. They looked at 400,000 different places on each person's genome. About 800 locations had differences in methylation that set identical twins apart from everyone else, the team reports today in Nature Communications. "It's likely something established very early on that is propagated to subsequent cells," van Dongen says.

Some of the methylated or unmethylated spots made sense, such as tags on genes involved in cell adhesion that might influence how easily a fertilized egg splits into two embryos. But changes in other locations, such as the ends of chromosomes, don't have an obvious explanation. These regions have been associated with aging, yet identical twins' life spans are similar to other people's. An epigenetic test might also be useful to determine whether a person once had an identical twin that vanished in the uterus, perhaps because it didn't have enough room or nutrients to grow. Sometimes a twin fetus appears in an ultrasound before vanishing, but other times it may be absorbed without leaving a trace. As many as 12% of pregnancies start out as multiples (including fraternal twins), according to some estimates, but only 2% of twin pairs survive. Using a separate data set, the epigenetic signature could predict whether someone was an identical twin in 70% to 80% of cases, van Dongen says. With data from a large enough group of people, the test would get even better, she says, and it could also help "predict the exact rate" of vanishing twins. That figure would be useful not only for researchers, but also "of broad interest" to twins themselves and to families who are mourning the loss of an identical twin, Boomsma says.

Medicine

Apple Watch Can Detect Arrhythmias Other Than AFib, Study Shows (myhealthyapple.com) 22

According to new research published this week in American Heart Association Journal, Apple Watch can detect arrhythmias other than Atrial Fibrillation (AFib). The Apple watch irregular pulse detection algorithm was found to have a positive predictive value of 0.84 for the identification of atrial fibrillation (AFib). MyHealthyApple reports: The Apple Heart Study investigated a smartwatch-based irregular pulse notification algorithm to identify AFib. For this secondary analysis, the researchers analyzed participants who received an ambulatory ECG patch after index irregular pulse notification. Among 419,297 participants enrolled in the Apple Heart Study, 450 participant ECG patches were analyzed, with no AF on 297 ECG patches (66%). Non-AF arrhythmias (excluding supraventricular tachycardias [less than] 30 beats and pauses [less than] 3 seconds) were detected in 119 participants (40.1%) with ECG patches without AFib. 76 participants (30.5%) reported subsequent AF diagnoses. In participants with an irregular pulse notification on the Apple Watch and no AF observed on ECG patch, atrial and ventricular arrhythmias, mostly PACs and PVCs, were detected in 40% of participants.
Space

This May Be the First Planet Found Orbiting 3 Stars at Once (nytimes.com) 51

GW Ori is a star system 1,300 light years from Earth in the constellation of Orion. It is surrounded by a huge disk of dust and gas, a common feature of young star systems that are forming planets. But fascinatingly, it is a system with not one star, but three. From a report: As if that were not intriguing enough, GW Ori's disk is split in two, almost like Saturn's rings if they had a massive gap in between. And to make it even more bizarre, the outer ring is tilted at about 38 degrees. Scientists have been trying to explain what is going on there. Some hypothesized that the gap in the disk could be the result of one or more planets forming in the system. If so, this would be the first known planet that orbits three stars at once, also known as a circumtriple planet.

Now the GW Ori system has been modeled in greater detail, and researchers say a planet -- a gassy world as massive as Jupiter -- is the best explanation for the gap in the dust cloud. Although the planet itself cannot be seen, astronomers may be witnessing it carve out its orbit in its first million years of its existence. A paper on the finding was published in September in the Monthly Notices of the Royal Astronomical Society. The scientists say it disproves an alternative explanation -- that the gravitational torque of the stars cleared the space in the disk. Their paper suggests there is not enough turbulence in the disk, known as its viscosity, for this explanation to suffice The finding also highlights how much more there is to learn about the unexpected ways in which planets can form.

Earth

Air Pollution Likely Cause of Up To 6 Million Premature Births, Study Finds (theguardian.com) 48

Air pollution is likely to have been responsible for up to 6 million premature births and 3 million underweight babies worldwide every year, research shows. From a report: The analysis, which combines the results of multiple scientific studies, is the first to calculate the total global burden of outdoor and indoor air pollution combined. Indoor pollution, mostly from cooking stoves burning solid fuel such as coal or wood, made up almost two-thirds of the total pollution burden on pregnancies in 2019, according to the latest findings. This is especially true in developing areas, such as in some parts of south-east Asia and sub-Saharan Africa. "At an individual level, indoor air pollution exposure appears to carry a much higher burden compared to outdoor levels," said Rakesh Ghosh, an epidemiologist at University of California, San Francisco and lead researcher on the paper, published in the journal Plos Medicine.

"So, minimising household pollution exposure, to the extent possible, should be part of the message during prenatal care, especially where household pollution is prevalent." Air pollution is usually measured according to exposure to particulate matter smaller than 2.5 microns: once inhaled, the minuscule size of these particles allows them to be absorbed deep into the bloodstream, potentially causing far-reaching health problems.

Australia

Little Fluffy Clouds May Help Save Australia's Great Barrier Reef (reuters.com) 20

To slow the speed at which high temperatures and warm waters bleach the corals of the Great Barrier Reef, Australian scientists are spraying droplets of ocean water into the sky to form clouds to protect the environmental treasure. From a report: Researchers working on the so-called Cloud Brightening project said they use a turbine to spray microscopic sea particles to thicken existing clouds and reduce sunlight on the world's largest coral reef ecosystem located off Australia's northeast coast. The water droplets evaporate leaving only tiny salt crystals which float up into the atmosphere allowing water vapour to condense around them, forming clouds, said Daniel Harrison, a senior lecturer at Southern Cross University, who runs the project.

"If we do it over an extended period of time for a few weeks to a couple of months when the corals are experiencing a marine heatwave we can actually start to lower the water temperature over the Reef," said Harrison. The project had its second trial in March, the end of the Southern Hemisphere summer when the Reef off Australia's northeast is at its hottest, gathering valuable data on the atmosphere when corals are at most risk of bleaching. A combination of light and warm water causes coral bleaching. By cutting light over the reef by 6% in summer, "bleaching stress" would be cut by 50% to 60% on the undersea ecosystem, Harrison said.

Science

Prosecutors in Mexico Seeking Arrest Warrants For More Than 30 Scientists (theguardian.com) 57

Mexico's scientific community has reacted with outrage after the country's chief prosecutor requested arrest warrants for 31 scientists, researchers and academics on accusations of organised crime, money laundering and embezzlement -- charges that could land them alongside drug cartel kingpins in one of the country's most notorious lockups. From a report: A judge at the maximum security Altiplano prison -- from which Joaquin "El Chapo" Guzman escaped in 2015 -- denied granting the arrest warrants on Wednesday. But the federal prosecutor immediately announced plans to pursue arrest warrants for the third time. The university professors have been accused of violating a law that prevents members of an advisory board from receiving money from a government science fund. But that law was passed in 2019, and the scientists got the $2.5m years earlier when it was apparently legal. Those involved have denied the funds were illegal or misused. The National Council on Science and Technology (Conacyt) has described the reaction to the arrest warrant applications as "a concerted wave of disinformation," which was spreading "terror" in the scientific community.
AI

Samsung Engineers Propose 'Copying and Pasting' the Brain onto AI Chips (engadget.com) 134

Samsung has proposed a way to build brain-like computer chips by "copying and pasting" a brain's neuron wiring map onto 3D neuromorphic chips. Engadget reports: The approach would rely on a nanoelectrode array that enters a large volumes of neurons to record both where the neurons connect and the strength of those connections. You could copy that data and 'paste' it to a 3D network of solid-state memory, whether it's off-the-shelf flash storage or cutting-edge memory like resistive RAM. Each memory unit would have a conductance that reflects the strength of each neuron connection in the map. The result would be an effective return to "reverse engineering the brain" like scientists originally wanted, Samsung said.

The move could serve as a 'shortcut' to artificial intelligence systems that behave like real brains, including the flexibility to learn new concepts and adapt to changing conditions. You might even see fully autonomous machines with true cognition, according to the researchers.

"Envisioned by the leading engineers and scholars from Samsung and Harvard University, the insight was published as a Perspective paper, titled 'Neuromorphic electronics based on copying and pasting the brain'..." Samsung said in a statement.

In short, they're proposing a method that "directly downloads the brain's neuronal connection map onto the memory chip."
Science

The World's Longest Cave System Just Got Even Longer (livescience.com) 82

schwit1 shared this report from LiveScience: The world's longest known cave system just set a new record after surveyors spent hours mapping an additional 8 miles (13 kilometers) of the passageways at Mammoth Cave National Park in Kentucky.

The corridors at Mammoth Cave now measure a whopping 420 miles (676 km) in length, according to the National Park Service (NPS). That's about the distance between New York City and Raleigh, North Carolina.

Mapping the cave system was a huge undertaking, carried out by volunteers at the Cave Research Foundation (CRF), a Kentucky-based nonprofit group, and other locals, including those from the Central Kentucky Karst Coalition. "Many of the cave trips are long and arduous, involving climbing, vertical exposure, squeezes, crawlways, water and mud," Karen Willmes, the eastern operations manager with CRF, said in an NPS statement... "After the trip, cartographers turn the data collected on the cave trip into a map. Other volunteers provide surface support.

Earth

Scientists Find Hormone That Allows Seeds To Germinate In Low Water Conditions (ucr.edu) 26

Slashdot reader StellarThoughts shares an announcement from the University of California, Riverside. (Alternate URL): Plants have the ability to perceive drought. When they do, they emit a hormone that helps them hold on to water. This same hormone, ABA, sends a message to seeds that it isn't a good time to germinate, leading to lower crop yields and less food in places where it's hot — an increasingly long list as a result of climate change.

"If you block ABA, you mess with the chemical pathway that plants use to prevent seed germination," said Aditya Vaidya, UC Riverside project scientist and study author. "Our new chemical, Antabactin, does exactly this. If we apply it, we have shown that dormant seeds will sprout."

Demonstrations of Antabactin's effectiveness are described in a new paper published in the Proceedings of the National Academy of Sciences. This work builds on the same team's creation of a chemical that mimics the effects of the ABA hormone, produced by plants in response to drought stress. That chemical, Opabactin, slows a plant's growth so it conserves water and doesn't wilt. It works by inducing plants to close tiny pores in their leaves and stems, which prevents water from escaping. Next, the team wanted to find a molecule that would have the opposite effect, opening the pores, encouraging germination and increasing plant growth. Though seed dormancy has largely been removed through breeding, it is still a problem in some crops like lettuce. Sean Cutler, a UC Riverside plant cell biology professor and study co-author, said accelerating and slowing plant growth are important tools for farmers. "Our research is all about managing both of these needs," he said...

In their paper, the team members showed that applying Antabactin to barley and tomato seeds accelerated germination. Conceivably, both Antabactin and Opabactin could work together to help crops flourish in a world becoming drier and hotter. Once Antabactin has helped seeds sprout into healthy plants, a farmer might start saving water early in the growing season by spraying Opabactin. This way, enough water is "banked" for when the plants start flowering.

Science

Can Antimatter Be Generated in a Lab? (popularmechanics.com) 83

"An international team of physicists have come up with a way to generate antimatter in the lab," reports Popular Mechanics, theoretically "allowing them to recreate conditions that are similar to those near a neutron star." This setup, at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) research laboratory in Germany, involves two high-intensity laser beams that can generate a jet of antimatter, as outlined in a paper published earlier this summer in the journal Communications Physics. That could make antimatter-based research far more accessible for scientists around the world...

it's tremendously difficult to recreate a neutron star's extreme conditions in terms of the science and logistics — imagine if a sugar cube weighed as much as Mount Everest in your laboratory! Two, scientists want to make antimatter for further analysis in the lab... So how did the researchers at Helmholtz-Zentrum Dresden-Rossendorf figure out how to generate antimatter? They're using opposing lasers in a setup they're referring to as a laser pincer... There's a tiny piece of plastic that both lasers shoot toward. As the lasers destroy the plastic, they send clouds of electrons toward each other... By smashing particles together between two lasers, scientists can begin to approach the intensely concentrated gravity and matter of a neutron star...

In this case, scientists are still speculating that the laser pincers will work, with support from a computer simulation that has helped them test and confirm their theory. Now, the next step is to begin building the rig that will really fire the lasers. "[C]olleagues are developing a platform that can be used to experimentally test whether the magnetic fields actually form as our simulations predict," HZDR physicist Toma Toncian says.

Thanks to Slashdot reader Third Position for submitting the article!

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