alternative_right shares a report from ScienceDaily: Scientists may have finally uncovered the mystery behind ultra-high-energy cosmic rays -- the most powerful particles known in the universe. A team from NTNU suggests that colossal winds from supermassive black holes could be accelerating these particles to unimaginable speeds. These winds, moving at half the speed of light, might not only shape entire galaxies but also fling atomic nuclei across the cosmos with incredible energy. [...]

But what on earth does that mean? The Milky Way is the neighborhood in the universe where you and I live. Our Sun and solar system are part of this galaxy, along with at least 100 billion other stars. "There is a black hole called Sagittarius-A* located right in the centre of the Milky Way. This black hole is currently in a quiet phase where it isn't consuming any stars, as there is not enough matter in the vicinity," [said postdoctoral fellow Enrico Peretti from the Universite Paris Cite]. This contrasts with growing, supermassive, active black holes that consume up to several times the mass of our own Sun each year. "A tiny portion of the material can be pushed away by the force of the black hole before it is pulled in. As a result, around half of these supermassive black holes create winds that move through the universe at up to half the speed of light," Peretti said.

We have known about these gigantic winds for approximately ten years. The winds from these black holes can affect galaxies. By blowing away gases, they can prevent new stars from forming, for example. This is dramatic enough in itself, but Oikonomou and her colleagues looked at something else, much smaller, that these winds could be the cause of." It is possible that these powerful winds accelerate the particles that create the ultra-high-energy radiation," said [lead author Domenik Ehlert]. The findings have been published in the journal Monthly Notices of the Royal Astronomical Society.

An anonymous reader quotes a report from The Guardian: The heads of UK physics departments say their subject is facing a national crisis as one in four warns that their university departments are in danger of closing because of funding pressures. In an anonymous survey of department heads by the Institute of Physics (IoP), 26% said they faced potential closure of their department within the next two years, while 60% said they expected courses to be reduced. Four out of five departments said they were making staff cuts, and many were considering mergers or consolidation in what senior physicists described as a severe threat to the UK's future success. [...]

To avoid "irreversible damage", the IoP is asking for immediate government action including funding to support existing labs and research facilities, as well as setting up an "early warning system" to monitor departments at risk of closure, and reduce pressures affecting international student recruitment. In the longer term it is calling for radical reforms in higher education funding to allow universities to meet the full costs of teaching nationally important subjects such as physics. Sir Keith Burnett, the IoP's president and a former chair of physics at Oxford University, said: "While we understand the pressures on public finances, it would be negligent not to sound the alarm for a national capability fundamental to our wellbeing, competitiveness and the defense of the realm.

"We are walking towards a cliff edge but there is still time to avert a crisis which would lead not just to lost potential but to many physics departments shutting down altogether. Physics researchers and talented physics students are our future but if action isn't taken now to stabilize, strengthen and sustain one of our greatest national assets, we risk leaving them high and dry." Thomas said the erosion in value of domestic tuition fees and falling numbers of international students were behind the financial pressures, with smaller physics departments the most at risk. "What that means is we will get more and more concentration of where physics is being taught and lose geographical distribution. That goes against aims of widening participation and means some disadvantaged groups will miss out on opportunities to study physics, and it's important that we recognize that," Thomas said.

AstraZeneca has licensed Algen Biotechnologies' AI-powered gene-editing platform, AlgenBrain, to develop immune-related therapies in a deal worth up to $555 million. Reuters reports: AstraZeneca will get exclusive rights to develop and sell approved therapies, if any, that target immune system-related disorders in exchange for upfront and milestone payments to Algen. AstraZeneca has been advancing its cell and gene therapy capabilities through acquisitions and partnerships as it works towards its target of $80 billion in sales by 2030. Globally too, drugmakers are increasingly turning to artificial intelligence for drug development.

Monday's deal, however, does not include AstraZeneca buying a stake in the company, Algen CEO and co-founder Chun-Hao Huang told Reuters in an interview. "Together with AstraZeneca's deep expertise in translational science and clinical development, we aim to uncover new biological insights to accelerate the development of novel therapies," Huang said. Algen was spun out from the UC Berkeley lab where biochemist Jennifer Doudna pioneered the CRISPR technology that won her the Nobel Prize. The biotech firm's AI platform, AlgenBrain, can map genes to disease outcomes, helping the companies decide their development focus for targeted therapies.

California biotech entrepreneur and former magician Serhat Gumrukcu has been found guilty of orchestrating the 2018 murder of his business rival Gregory Davis, who had threatened to expose Gumrukcu's fraudulent dealings. He faces sentencing in November. SFGATE reports: Seven years ago, Turkish national Serhat Gumrukcu, 42, of Los Angeles, was negotiating a multimillion-dollar biotech merger built off his work on a supposed HIV cure. The deal was put in jeopardy by a former business partner named Gregory Davis, 49, who had threatened to bring legal action against Gumrukcu for fraudulent activities relating to a previous failed oil commodities deal, the U.S. Attorney's Office said in a news release last week. Gumrukcu, a magician-turned-scientist who admitted to buying his medical degree from a Russian university, lived in a Hollywood mansion and partied with Oscar winners and movie producers, according to VTDigger. He stood to make millions from the merger of his biotech company Enochian BioSciences. [...]

In 2017, upon learning that Davis, a father of six from Danville, Vermont, could potentially spoil his fortune-making deal, Gumrukcu set in motion a hit on the former business partner. The murder-for-hire plot involved four men in total, prosecutors said. Gumrukcu had a close friend from Las Vegas, Berk Eratay, approach a third man, Aron Ethridge to find a hit man to kill Davis. The shooter, 37-year-old Montana man Jerry Banks, arrived at Davis' home on Jan. 6, 2018, in a vehicle fitted with flashing red and blue lights and posed as a deputy U.S. marshal. After abducting Davis, Banks shot him dead in the vehicle and left the body partially buried in a snowbank nearby.

Investigators soon narrowed in on Gumrukcu after discovering emails between him and Davis revealing tensions over the failed oil deal. Gumrukcu was interviewed twice by the FBI and made false statements on both occasions, federal prosecutors said. Further inspection of cellphone data, bank information and messages identified the four men involved in the kidnapping and killing of Davis.

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the Nobel Prize in Physiology or Medicine on Monday for their discoveries about how the immune system regulates itself. The three researchers split 11 million Swedish kroner ($1.17 million). Their work identified regulatory T cells and the FOXP3 gene that controls them. Dr. Sakaguchi spent more than a decade solving a puzzle about the thymus. He discovered that the immune system has a backup mechanism to stop harmful cells from attacking the body's own tissues. Dr. Brunkow and Dr. Ramsdell found the specific gene responsible for this process while studying mice that developed severe autoimmune disease.

More than 200 clinical trials are now underway based on their research. Cancers attract regulatory T cells to block immune attacks. Researchers are developing drugs to turn the immune system against these cancer cells. In autoimmune diseases, regulatory T cells are missing or defective. The FOXP3 gene provides a starting point for drugs that teach the immune system to stop attacking itself.

If we could remove the 50 most concerning pieces of space debris in low-Earth orbit, there'd be a 50% reduction in the overall debris-generating potential, reports Ars Technica. That's according to Darren McKnight, lead author of a paper presented Friday at the International Astronautical Congress in Sydney, which calculated the objects most likely to collide with other fragments and create more debris. (Russia and the Soviet Union lead with 34 objects, followed by China with 10, the U.S. with three, Europe with two, and Japan with one.) Even just the top 10 were removed, the debris-generating potential drops by 30%.

"The things left before 2000 are still the majority of the problem," he points out, and "76% of the objects in the top 50 were deposited last century." 88% of the objects are post-mission rocket bodies left behind to hurtle through space. "The bad news is, since January 1, 2024, we've had 26 rocket bodies abandoned in low-Earth orbit that will stay in orbit for more than 25 years," McKnight told Ars... China launched 21 of the 26 hazardous new rocket bodies over the last 21 months, each averaging more than 4 metric tons (8,800 pounds). Two more came from US launchers, one from Russia, one from India, and one from Iran. This trend is likely to continue as China steps up deployment of two megaconstellations — Guowang and Thousand Sails — with thousands of communications satellites in low-Earth orbit.

Launches of these constellations began last year. The Guowang and Thousand Sails satellites are relatively small and likely capable of maneuvering out of the way of space debris, although China has not disclosed their exact capabilities. However, most of the rockets used for Guowang and Thousand Sails launches have left their upper stages in orbit. McKnight said nine upper stages China has abandoned after launching Guowang and Thousand Sails satellites will stay in orbit for more than 25 years, violating the international guidelines.

It will take hundreds of rockets to fully populate China's two major megaconstellations. The prospect of so much new space debris is worrisome, McKnight said. "In the next few years, if they continue the same trend, they're going to leave well over 100 rocket bodies over the 25-year rule if they continue to deploy these constellations," he said. "So, the trend is not good...." Since 2000, China has accumulated more dead rocket mass in long-lived orbits than the rest of the world combined, according to McKnight. "But now we're at a point where it's actually kind of accelerating in the last two years as these constellations are getting deployed."
A deputy head of China's national space agency recently said China is "currently researching" how to remove space debris from orbit, according to the article. ("One of the missions China claims is testing space debris mitigation techniques has docked with multiple spacecraft in orbit, but U.S. officials see it as a military threat. The same basic technologies needed for space debris cleanup — rendezvous and docking systems, robotic arms, and onboard automation — could be used to latch on to an adversary's satellite.")

ScienceAlert writes that some of the tiny nanoplastic fragments present in soil "can make their way into the edible parts of vegetables, research has found." A team of scientists from the University of Plymouth in the UK placed radishes into a hydroponic (water-based) system containing polystyrene nanoparticles. After five days, almost 5% of the nanoplastics had made their way into the radish roots. A quarter of those were in the edible, fleshy roots, while a tenth had traveled up to the higher leafy shoots, despite anatomical features within the plants that typically screen harmful material from the soil.

"Plants have a layer within their roots called the Casparian strip, which should act as a form of filter against particles, many of which can be harmful," says physiologist Nathaniel Clark. "This is the first time a study has demonstrated nanoplastic particles could get beyond that barrier, with the potential for them to accumulate within plants and be passed on to anything that consumes them...."

There are some limitations to the study, as it didn't use a real-world farming setup. The concentration of plastics in the liquid solution is higher than estimated for soil, and only one type of plastic and one kind of vegetable were tested. Nevertheless, the basic principle stands: the smallest plastic nanoparticles can apparently sneak past protective barriers in plants, and from there into the food we eat... "There is no reason to believe this is unique to this vegetable, with the clear possibility that nanoplastics are being absorbed into various types of produce being grown all over the world," says Clark.
The research has been published in Environmental Research.

Currently DNA synthesis companies "deploy biosecurity software designed to guard against nefarious activity," reports the Washington Post, "by flagging proteins of concern — for example, known toxins or components of pathogens." But Microsoft researchers discovered "up to 100 percent" of AI-generated ricin-like proteins evaded detection — and worked with a group of leading industry scientists and biosecurity experts to design a patch. Microsoft's chief science officer called it "a Windows update model for the planet.

"We will continue to stay on it and send out patches as needed, and also define the research processes and best practices moving forward to stay ahead of the curve as best we can."

But is that enough? Outside biosecurity experts applauded the study and the patch, but said that this is not an area where one single approach to biosecurity is sufficient. "What's happening with AI-related science is that the front edge of the technology is accelerating much faster than the back end ... in managing the risks," said David Relman, a microbiologist at Stanford University School of Medicine. "It's not just that we have a gap — we have a rapidly widening gap, as we speak. Every minute we sit here talking about what we need to do about the things that were just released, we're already getting further behind."
The Washington Post notes not every company deploys biosecurity software. But "A different approach, biosecurity experts say, is to ensure AI software itself is imbued with safeguards before digital ideas are at the cusp of being brought into labs for research and experimentation." "The only surefire way to avoid problems is to log all DNA synthesis, so if there is a worrisome new virus or other biological agent, the sequence can be cross-referenced with the logged DNA database to see where it came from," David Baker, who shared the Nobel Prize in chemistry for his work on proteins, said in an email.

An anonymous reader shared this report from the Washington Post: Women tend to live longer than men. There are traditional explanations: Men smoke more. They drink more. They tend to engage in riskier behavior. But the fact that this lifespan gap holds true regardless of country or century indicates something deeper is also at play.

A growing body of evidence suggests that women's relative longevity may derive, in part, from having double X chromosomes, a redundancy that protects them against harmful mutations. That theory was further bolstered Wednesday with the publication of the most sweeping analysis to date of the lifespan differences between males and females in more than 1,000 mammal and bird species...

If a baby has a pair of X chromosomes, she's a girl. If the baby inherits an X chromosome and a Y chromosome, he's a boy. In birds, however, the situation is reversed. Female birds have a pair of unlike sex chromosomes while males have the like pair... For their study, Colchero, Staerk and their colleagues collected data on the lifespans of 528 mammal species and 648 bird species kept in zoos. The team found that most other mammals are like humans, with the females of nearly three-fourths of mammal species outliving their male counterparts. But in birds, 68 percent of species studied showed a bias toward male longevity, as expected from their chromosomal makeup.

"A small number of researchers are making real progress trying to create computers out of living cells," reports the BBC: Among those leading the way are a group of scientists in Switzerland, who I went to meet. One day, they hope we could see data centres full of "living" servers which replicate aspects of how artificial intelligence (AI) learns — and could use a fraction of the energy of current methods.

That is the vision of Dr Fred Jordan, co-founder of the FinalSpark lab I visited. We are all used to the ideas of hardware and software in the computers we currently use. The somewhat eyebrow-raising term Dr Jordan and others in the field use to refer to what they are creating is "wetware". In simple terms, it involves creating neurons which are developed into clusters called organoids, which in turn can be attached to electrodes — at which point the process of trying to use them like mini-computers can begin...

For FinalSpark, the process begins with stem cells derived from human skin cells, which they buy from a clinic in Japan. The actual donors are anonymous... In the lab, FinalSpark's cellular biologist Dr Flora Brozzi handed me a dish containing several small white orbs. Each little sphere is essentially a tiny, lab-grown mini-brain, made out of living stem cells which have been cultured to become clusters of neurons and supporting cells — these are the "organoids"... After undergoing a process which can last several months, the organoids are ready to be attached to an electrode and then prompted to respond to simple keyboard commands... Electrical stimulations are important first steps towards the team's bigger goal of triggering learning in the biocomputer's neurons so they can eventually adapt to perform tasks...

FinalSpark are not the only scientists working in the biocomputing space. Australian firm Cortical Labs announced in 2022 that it had managed to get artificial neurons to play the early computer game Pong. In the US, researchers at Johns Hopkins University are also building "mini-brains" to study how they process information — but in the context of drug development for neurological conditions like Alzheimer's and autism.
Thanks to long-time Slashdot reader fjo3 for sharing the news.

Jeff Bezos told an audience on Friday that gigawatt-scale data centers will be built in space within the next ten to twenty years. The Amazon founder said these orbital facilities would eventually outperform their terrestrial counterparts because space offers uninterrupted solar power around the clock.

Bezos was speaking in a fireside chat with Ferrari and Stellantis Chairman John Elkann. He said the giant training clusters needed for AI would be better built in space because there are no clouds, rain or weather to interrupt power generation. Bezos predicted that space-based data centers would beat the cost of Earth-based ones within a couple of decades. He described the shift as part of a broader pattern that has already occurred with weather satellites and communication satellites. The next steps would be data centers and then other kinds of manufacturing.

Air pollution increases the likelihood of people becoming frail in middle and old age, according to an international review of studies. The Guardian: The review team found 10 studies that looked at outdoor air pollution and frailty. The people studied came from 11 countries including China, the UK, Sweden, South Africa and Mexico. Two of the studies showed that men were more vulnerable than woman, with a stronger association between particle pollution and frailty. The risk of frailty increased with outdoor particle pollution. For the UK, this could mean about 10-20% of frailty cases are attributable to air pollution.

Exposure to secondhand smoking was the environmental factor that presented the greatest risk of frailty. The risk of frailty was increased by about 60% for people who breathed other people's smoke at home. Using solid fuels for cooking or home heating also carried an extra risk of frailty. This was about half the risk of living with a smoker, based on studies from six countries.

An anonymous reader quotes a report from MIT Technology Review: A team at Microsoft says it used artificial intelligence to discover a "zero day" vulnerability in the biosecurity systems used to prevent the misuse of DNA. These screening systems are designed to stop people from purchasing genetic sequences that could be used to create deadly toxins or pathogens. But now researchers led by Microsoft's chief scientist, Eric Horvitz, says they have figured out how to bypass the protections in a way previously unknown to defenders.The team described its work today in the journalScience.

Horvitz and his team focused on generative AI algorithms that propose new protein shapes. These types of programs are already fueling the hunt for new drugs at well-funded startups like Generate Biomedicines and Isomorphic Labs, a spinout of Google. The problem is that such systems are potentially "dual use." They can use their training sets to generate both beneficial molecules and harmful ones. Microsoft says it began a "red-teaming" test of AI's dual-use potential in 2023 in order to determine whether "adversarial AI protein design" could help bioterrorists manufacture harmful proteins.

The safeguard that Microsoft attacked is what's known as biosecurity screening software. To manufacture a protein, researchers typically need to order a corresponding DNA sequence from a commercial vendor, which they can then install in a cell. Those vendors use screening software to compare incoming orders with known toxins or pathogens. A close match will set off an alert. To design its attack, Microsoft used several generative protein models (including its own, called EvoDiff) to redesign toxins -- changing their structure in a way that let them slip past screening software but was predicted to keep their deadly function intact. "This finding, combined with rapid advances in AI-enabled biological modeling, demonstrates the clear and urgent need for enhanced nucleic acid synthesis screening procedures coupled with a reliable enforcement and verification mechanism," says Dean Ball, a fellow at the Foundation for American Innovation, a think tank in San Francisco.

Bruce66423 shares a report from The Guardian: Those diagnosed as small children typically have distinct genetic profile from those diagnosed later, [finds an international study based on genetic data from more than 45,000 autistic people in Europe and the U.S]. So, there's more than one condition out there that's being diagnosed as "autism." This, of course, messes with the debate about causes; one version of autism may be caused by something for which the evidence is very weak overall. "The term 'autism' likely describes multiple conditions," said Dr Varun Warrier, from Cambridge's department of psychiatry, senior author of the research. "For the first time, we have found that earlier and later diagnosed autism have different underlying biological and developmental profiles."

"It is a gradient," added Warrier. "There are also many other factors that contribute to age of diagnosis, so the moment you go from averages to anything that is applicable to an individual, it's false equivalency."

The analysis has been published in the journal Nature.

An anonymous reader shares a report: It's not the vibes; Earth is literally getting darker. Scientists have discovered that our planet has been reflecting less light in both hemispheres, with a more pronounced darkening in the Northern hemisphere, according to a study published on Monday in Proceedings of the National Academy of Sciences.

The new trend upends longstanding symmetry in the surface albedo, or reflectivity, of the Northern and Southern hemispheres. In other words, clouds circulate in a way that equalizes hemispheric differences, such as the uneven distribution of land, so that the albedos roughly match -- though nobody knows why. "There are all kinds of things that people have noticed in observations and simulations that tend to suggest that you have this hemispheric symmetry as a kind of fundamental property of the climate system, but nobody's really come up with a theoretical framework or explanation for it," said Norman Loeb, a physical scientist at NASA's Langley Research Center, who led the new study. "It's always been something that we've observed, but we haven't really explained it fully."

To study this mystery, Loeb and his colleagues analyzed 24 years of observations captured since 2000 by the Clouds and the Earth's Radiant Energy System (CERES), a network of instruments placed on several NOAA and NASA satellites. Instead of an explanation for the strange symmetry, the results revealed an emerging asymmetry in hemispheric albedo; though both hemispheres are darkening, the Northern hemisphere shows more pronounced changes which challenges "the hypothesis that hemispheric symmetry in albedo is a fundamental property of Earth," according to the study.

Scientists have discovered complex organic molecules within the icy plume erupting from Saturn's moon Enceladus, strengthening the case that its hidden saltwater ocean may harbor the conditions for life. The Guardian reports: The sixth largest of Saturn's moons, Enceladus has become one of the leading contenders in the search for bodies that could harbor extraterrestrial life, with the Cassini mission -- which ended in 2017 -- revealing the moon has a plume of water ice grains and vapors erupting from beneath the surface at its south pole. The phenomenon has since been captured by the James Webb space telescope, with the plume reaching nearly 6,000 miles into space. The source of this material is thought to be a saltwater ocean that lies beneath the moon's icy crust.

Now researchers studying data from the Cassini mission say they have discovered organic substances within the plume, with some types of molecule detected there for the first time. Dr Nozair Khawaja, a planetary scientist at Freie University Berlin and lead author of the work, said the results increased the known complexity of the chemistry that is happening below the surface of Enceladus. "When there is complexity happening, that means that the habitable potential of Enceladus is increasing right now," he said. Writing in the journal Nature Astronomy, Khawaja and colleagues reported how their previous work had revealed the presence of organic substances and salts within ice grains found in a ring of Saturn, known as the "E-ring," that is composed of material ejected from Enceladus. [...]

While the new findings do not show that there is life on Enceladus, Khawaja said they indicate there are complex chemical pathways at play that could lead to the formation of substances that could be biologically relevant. The results, he added, support plans by the European Space Agency (ESA) to investigate the moon for signs of life. "I think all the signals are green here for Enceladus," Khawaja said. The findings add momentum to ESA's proposed mission to directly search for biological signs around 2042. According to the ESA, the mission will consist of an orbiter around Enceladus that will also fly through the plumes, as well as a lander that will touch down in the south pole region of the moon.

Jane Goodall, world-renowned primatologist, anthropologist, and conservationist, has died at the age of 91 while on a speaking tour in California. The British primatologist's "discoveries as an ethologist revolutionized science, and she was a tireless advocate for the protection and restoration of our natural world," according to the institute she founded. From a report: Goodall was only 26 years old when she first traveled to Tanzania and began her important research on chimpanzees in the wild. Throughout her study of the species, Goodall proved that primates display an array of similar behaviors to humans, such as the ability to develop individual personalities and make and use their own tools. Among the most surprising discoveries Goodall made was "how like us" the chimpanzees are, she told ABC News in 2020.

"Their behavior, with their gestures, kissing, embracing, holding hands and patting on the back," she said. "... The fact that they can actually be violent and brutal and have a kind of war, but also loving an altruistic." That discovery is considered one of the great achievements of 20th-century scholarship, according to the Jane Goodall Institute. [...] Goodall's research garnered both scientific honors and mainstream fame, and she was credited with paving the way for a rise in women pursuing careers in STEM (science, technology, engineering and math) over the years. The number of women in STEM has increased from 7% to 26% in the six last decades, according to The Jane Goodall Institute, which cited census information from 1970 to 2011.

In 1991, she also founded Roots & Shoots, a global humanitarian and environmental program for young people. She was named a United Nations Messenger of Peace in April 2002. The anthropologist continued to lend her voice to environmental causes well into her 80s and 90s. In 2019, Goodall acknowledged the climate crisis and the importance of mitigating further warming, telling ABC News that the planet is "imperiled." "We are definitely at a point where we need to make something happen," she said.

"We are imperiled. We have a window of time. I'm fairly sure we do. But, we've got to take action." Goodall even partnered with Apple in 2022 to encourage customers to recycle their devices to reduce individual carbon footprint and cut down on unnecessary mineral mining around the world. "Yes, people need to make money, but it is possible to make money without destroying the planet," Goodall told ABC News at the time. "We've gone so far in destroying the planet that it's shocking."

alternative_right shares a report from Phys.org: For the first time, a new study has tested the effectiveness of trigger warnings in real life scenarios, revealing that the vast majority of young adults choose to ignore them. A new Flinders University study has found that nearly 90% of young people who saw a trigger warning still chose to view the content, saying that they did so out of curiosity, rather than because they felt emotionally prepared or protected. The findings published in the Journal of Behavior Therapy and Experimental Psychiatry aligned with a growing body of lab-based research suggesting that trigger warnings rarely lead to the avoidance of potentially distressing material.

An anonymous reader quotes a report from the BBC: US scientists have, for the first time, made early-stage human embryos by manipulating DNA taken from people's skin cells and then fertilizing it with sperm. The technique could overcome infertility due to old age or disease, by using almost any cell in the body as the starting point for life. It could even allow same-sex couples to have a genetically related child. [...]

The Oregon Health and Science University research team's technique takes the nucleus -- which houses a copy of the entire genetic code needed to build the body -- out of a skin cell. This is then placed inside a donor egg that has been stripped of its genetic instructions. So far, the technique is like the one used to create Dolly the Sheep -- the world's first cloned mammal -- born back in 1996. However, this egg is not ready to be fertilized by sperm as it already contains a full suite of chromosomes.

You inherit 23 of these bundles of DNA from each of your parents for a total of 46, which the egg already has. So the next stage is to persuade the egg to discard half of its chromosomes in a process the researchers have termed "mitomeiosis" (the word is a fusion of mitosis and meiosis, the two ways cells divide). The study, published in the journal Nature Communications, showed 82 functional eggs were made. These were fertilized with sperm and some progressed onto the early stages of embryos development. None were developed beyond the six-day-stage.

The technique is far from polished as the egg randomly chooses which chromosomes to discard. It needs to end up with one of each of the 23 types to prevent disease, but ends up with two of some and none of others. There is also a poor success rate (around 9%) and the chromosomes miss an important process where they rearrange their DNA, called crossing over. Prof Mitalipov, a world-renowned pioneer in the field, told me: "We have to perfect it. "Eventually, I think that's where the future will go because there are more and more patients that cannot have children."

Cancer rates among people aged 15 to 49 have increased 10% since 2000 even as rates have fallen among older populations. Young women face an 83% higher cancer rate than men in the same age range. A 150,000-person study presented at the American Association for Cancer Research meeting found millennials appear to be aging biologically faster than previous generations based on blood biomarkers. That acceleration was associated with up to 42% increased risk for certain cancers including lung, gastrointestinal and uterine malignancies.

Researchers are examining the "exposome" -- the full range of environmental exposures across a person's life. Studies have linked early-onset cancers to medications taken during pregnancy, ultra-processed foods that now account for more than half of daily calorie intake in the United States, circadian rhythm disruption from artificial light and shift work, and chemical exposures. Gary Patti at Washington University is using zebrafish exposed to known and suspected carcinogens to track tumor development. His lab has developed systems to scan blood samples for tens of thousands of chemicals simultaneously to identify signatures appearing more frequently in early-onset cancer patients.