Physicists using SLAC's X-ray free-electron laser discovered two new laser phenomena that allowed them to generate the shortest, highest-energy X-ray pulses ever recorded (60-100 attoseconds). These breakthroughs could let scientists observe electron motion and chemical bond formation in real time. Physicists Uwe Bergmann and Thomas Linker write in an article for The Conversation: In this new study we used X-rays, which have 100 million times shorter wavelengths than microwaves and 100 million times more energy. This meant the resulting new X-ray laser pulses were split into different X-ray wavelengths corresponding to Rabi frequencies in the extreme ultraviolet region. Ultraviolet light has a frequency 100 million times higher than radio waves. This Rabi cycling effect allowed us to generate the shortest high-energy X-ray pulses to date, clocking in at 60-100 attoseconds.

While the pulses that X-ray free-electron lasers currently generate allow researchers to observe atomic bonds forming, rearranging and breaking, they are not fast enough to look inside the electron cloud that generates such bonds. Using these new attosecond X-ray laser pulses could allow scientists to study the fastest processes in materials at the atomic-length scale and to discern different elements.

In the future, we also hope to use much shorter X-ray free-electron laser pulses to better generate these attosecond X-ray pulses. We are even hoping to generate pulses below 60 attoseconds by using heavier materials with shorter lifespans, such as tungsten or hafnium. These new X-ray pulses are fast enough to eventually enable scientists to answer questions such as how exactly an electron cloud moves around and what a chemical bond actually is. The findings have been published in the journal Nature.

fahrbot-bot shares a report from Popular Mechanics: [I]n a new study published in the journal Nature Materials, scientists from the Korea Research Institute of Standards and Science (KRISS) have now found yet another phase, appropriately named Ice XXI. At the heart of the experiment, scientists used diamond anvil cells (DACs) -- a common device used in materials science for squeezing samples under immense pressure -- to subject water to 2 gigapascals (20,000 times higher than normal atmosphere) of pressure in just 10 milliseconds.

The scientists call this kind of water "supercompressed," and it's metastable, meaning it persists for a time even when another form of ice would be more stable. And because of the immense pressure, ice forms at room temperature but the molecules are much more densely packed. "Rapid compression of water allows it to remain liquid up to higher pressures, where it should have already crystallized to ice VI," Geun Woo Lee, a co-author of the study from RISS, said in a press statement. "The structure in which liquid H2O crystallizes depends on the degree of supercompression of the liquid."

Scientists from Spain and China have successfully repaired the blood-brain barrier in Alzheimer's-model mice, enabling the brain to naturally clear amyloid-beta plaques and reverse cognitive decline. "After just three drug injections, mice with certain genes that mimic Alzheimer's showed a reversal of several key pathological features," adds ScienceAlert. From the report: Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months.

These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors say "heralds a new era" in drug research. "The therapeutic implications are profound," claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU). The findings have been published in Signal Transduction and Targeted Therapy.

An anonymous reader quotes a report from the Conversation: Sound waves at frequencies above the threshold for human hearing are routinely used in medical care. Also known as ultrasound, these sound waves can help clinicians diagnose and monitor disease, and can also provide first glimpses of your newest family members. And now, patients with conditions ranging from cancer to neurodegenerative diseases like Alzheimer's may soon benefit from recent advances in this technology.

I am a biomedical engineer who studies how focused ultrasound -- the concentration of sound energy into a specific volume -- can be fine-tuned to treat various conditions. Over the past few years, this technology has seen significant growth and use in the clinic. And researchers continue to discover new ways to use focused ultrasound to treat disease. [...] Research on focused ultrasound has primarily focused on the most devastating and prevalent diseases, such as cancer and Alzheimer's disease. However, I believe that further developments in, and increased use of, focused ultrasound in the clinic will eventually benefit patients with rare diseases.

One rare disease of particular interest for my lab is cerebral cavernous malformation, or CCM. CCMs are lesions in the brain that occur when the cells that make up blood vessels undergo uncontrolled growth. While uncommon, when these lesions grow and hemorrhage, they can cause debilitating neurological symptoms. The most common treatment for CCM is surgical removal of the brain lesions; however, some CCMs are located in brain areas that are difficult to access, creating a risk of side effects. Radiation is another treatment option, but it, too, can lead to serious adverse effects.

We found that using focused ultrasound to open the blood-brain barrier can improve drug delivery to CCMs. Additionally, we also observed that focused ultrasound treatment itself could stop CCMs from growing in mice, even without administering a drug. While we don't yet understand how focused ultrasound is stabilizing CCMs, abundant research on the safety of using this technique in patients treated for other conditions has allowed neurosurgeons to begin designing clinical trials testing the use of this technique on people with CCM. With further research and advancements, I am hopeful that focused ultrasound can become a viable treatment option for many devastating rare diseases.

Math teachers across American schools are contending with a classroom disruption that has proven impossible to contain. The numbers six and seven now trigger instant pandemonium among students. They scream the phrase and perform a palms-up seesaw hand gesture whenever the numbers appear in equations or instructions.

Teachers have begun avoiding breaking students into groups of six or seven or asking them to turn to page 67. The meme has no meaning, reports WSJ. That absence of meaning is the point. The phenomenon traces back to late last year when Philadelphia rapper Skrilla released "Doot Doot (6 7)," a song referencing 67th street where his friends grew up. The phrase spiraled into youth culture in March through a viral video of a boy with forward-swept hair lurching toward a camera to deliver an animated "six seven." Skrilla is now touring venues where audiences wait for the six-seven line. Some teachers have attempted to neutralize the meme by saying it themselves.

A new study shows that common baker's yeast (Saccharomyces cerevisiae) can survive Mars-like conditions, including meteorite shock waves and toxic perchlorate salts found in Martian soil. Phys.org reports: Published in PNAS Nexus, Purusharth I. Rajyaguru and colleagues subjected Saccharomyces cerevisiae, which is a widely used model yeast, to shock waves and perchlorates. The authors chose the yeast in part because it has already been studied in space. When stressed, yeast, humans, and many other organisms form ribonucleoprotein (RNP) condensates, structures made of RNA and proteins that protect RNA and affect the fates of mRNAs. When the stressor passes, the RNP condensates, which include subtypes known as stress granules and P-bodies, disassemble.

The authors simulated Martian shock waves at the High-Intensity Shock Tube for Astrochemistry (HISTA) housed in the Physical Research Laboratory in Ahmedabad, India. Yeast exposed to 5.6 Mach intensity shock waves survived with slowed growth, as did yeast subjected to 100 mM sodium salt of perchlorate (NaClO4) -- a concentration similar to that in Martian soils. Yeast cells also survived exposure to the combined stress of shock waves and perchlorate stress. In both cases, the yeast assembled RNP condensates. Shock waves induced the assembly of stress granules and P-bodies; perchlorate caused yeast to make P-bodies but not stress granules. Mutants incapable of assembling RNP condensates were poor at surviving the Martian stress condition. Transcriptome analysis identified specific RNA transcripts perturbed by Mars-like conditions.

Researchers at UC San Diego and the University of Maryland have found that roughly half of geostationary satellite signals transmit sensitive data without encryption. The team spent three years using an $800 satellite receiver on a university rooftop in San Diego to intercept communications from satellites visible from their location. They collected phone calls and text messages from more than 2,700 T-Mobile users in just nine hours of recording.

The researchers also obtained data from airline passengers using in-flight Wi-Fi, communications from electric utilities and offshore oil and gas platforms, and US and Mexican military communications that revealed personnel locations and equipment details. The exposed data resulted from telecommunications companies using satellites to relay signals from remote cell towers to their core networks.

The researchers examined only about 15% of global satellite transponder communications and presented their findings at an Association for Computing Machinery conference in Taiwan this week. Most companies warned by the researchers have encrypted their satellite transmissions, but some US critical infrastructure owners have not yet added encryption.

NASA's Jet Propulsion Laboratory is laying off around 550 employees, or roughly 11% of its workforce, as part of an effort to "restructure and establish an appropriate size to ensure future success." According to JPL Director Dave Gallagher, the job cuts "are not related to the current government shutdown." CNBC reports: JPL is a research and development lab funded by NASA -- the federal space agency -- and managed by the California Institute of Technology. "While not easy, I believe that taking these actions now will help the Lab transform at the scale and pace necessary to help achieve humanity's boldest ambitions in space," Gallagher wrote in a separate mekor to JPL employees and contractors. Gallagher, in the public announcement, noted that the reorganization of JPL began in July, and "over the past few months, we have communicated openly with employees about the challenges and hard choices ahead."

"This week's action, while not easy, is essential to securing JPL's future by creating a leaner infrastructure, focusing on our core technical capabilities, maintaining fiscal discipline, and positioning us to compete in the evolving space ecosystem -- all while continuing to deliver on our vital work for NASA and the nation," Gallagher wrote. Gallagher said that JPL employees will be notified of their status on Tuesday, and the "new Lab structure ... will become effective Wednesday."

SpaceX's Starship megarocket successfully completed its 11th test flight, achieving major milestones like engine relight, satellite deployment, and a controlled splashdown in the Indian Ocean. From a report: This mission marks the second clean test run for Version 2, following a successful showing during its last test mission in August. Earlier this year, however, Starship Version 2 suffered three in-flight failures and an explosive accident during ground testing. Today's test mission is expected to be the last for the current iteration of Starship prototypes. The company has said it will debut a scaled up Version 3 for the next flight. You can watch a recording of the launch on YouTube.

ScienceDaily reports: Our everyday GPS struggles in "urban canyons," where skyscrapers bounce satellite signals, confusing even advanced navigation systems. Norwegian University of Science and Technology (NTNU) scientists created SmartNav, combining satellite corrections, wave analysis, and Google's 3D building data for remarkable precision. Their method achieved accuracy within 10 centimeters during testing [90% of the time]. The breakthrough could make reliable urban navigation accessible and affordable worldwide...

"Cities are brutal for satellite navigation," explained Ardeshir Mohamadi. Mohamadi, a doctoral fellow at NTNU, is researching how to make affordable GPS receivers (like those found in smartphones and fitness watches) much more precise without depending on expensive external correction services.

Off the southwest cost of Italy, a remotely operated submarine made "a significant and rare discovery," reports the Independent — a vast white coral reef that was 80 metres tall (262 feet) and 2 metres wide (6.56 feet) "containing important species and fossil traces." Often dubbed the "rainforests of the sea", coral reefs are of immense scientific interest due to their status as some of the planet's richest marine ecosystems, harbouring millions of species. They play a crucial role in sustaining marine life but are currently under considerable threat...

hese impressive formations are composed of deep-water hard corals, commonly referred to as "white corals" because of their lack of colour, specifically identified as Lophelia pertusa and Madrepora oculata species. The reef also contains black corals, solitary corals, sponges, and other ecologically important species, as well as fossil traces of oysters and ancient corals, the Italian Research Council said. It called them "true geological testimonies of a distant past."

Mission leader Giorgio Castellan said the finding was "exceptional for Italian seas: bioconstructions of this kind, and of such magnitude, had never been observed in the Dohrn Canyon, and are rarely seen elsewhere in our Mediterranean". The discovery will help scientists understand the ecological role of deep coral habitats and their distribution, especially in the context of conservation and restoration efforts, he added.
The undersea research was funded by the EU.

Thanks to davidone (Slashdot reader #12,252) for sharing the article.

fjo3 shares a report from the Washington Post: Across vast stretches of farmland in southern Brazil, researchers at a carbon removal company are attempting to accelerate a natural process that normally unfolds over thousands or millions of years. The company, Terradot, is spreading tons of volcanic rock crushed into a fine dust over land where soybeans, sugar cane and other crops are grown. As rain percolates through the soil, chemical reactions pull carbon from the air and convert it into bicarbonate ions that eventually wash into the ocean, where the carbon remains stored. The technique, known as "enhanced rock weathering," is emerging as a promising approach to lock away carbon on a massive scale. Some researchers estimate the method has the potential to sequester billions of tons of carbon, helping slow global climate trends. Other major projects are underway across the globe and have collectively raised over a quarter-billion dollars. [...]

Terradot was founded in 2022 at Stanford, growing out of an independent study between James Kanoff, an undergraduate seeking large-scale carbon removal solutions, and Scott Fendorf, an Earth science professor. Terradot ran a pilot project across 250 hectares in Mexico and began operations in Brazil in late 2023. Since then, the company has spread about 100,000 tons of rock over 4,500 hectares. It has signed contracts to remove about 300,000 tons of carbon dioxide and is backed by a who's who of Silicon Valley. It expects to deliver its first carbon removal credit -- representing one metric ton of verified carbon dioxide removed -- by the end of this year and then scale up from there.

Doug Whitney carries a genetic mutation that guaranteed he would develop Alzheimer's disease in his late forties or early fifties. His mother and nine of her thirteen siblings died from the disease. His oldest brother died at 45. The mutation has decimated his family for generations. Whitney is now 76 and remains cognitively healthy. The New York Times has a fascinating long read on Whitney and things happening around him.

Scientists at Washington University School of Medicine in St. Louis have studied Whitney for 14 years. They extract his cerebrospinal fluid and conduct brain scans during his periodic visits from Washington State. His brain contains heavy amyloid deposits but almost no tau tangles in regions associated with dementia. Tau accumulation correlates directly with cognitive decline. Whitney accumulated tau only in his left occipital lobe, an area that does not play a major role in Alzheimer's.

Researchers identified several possibly protective factors in Whitney's biology. His immune system produces a lower inflammatory response than other mutation carriers. He has unusually high levels of heat shock proteins, which prevent proteins from misfolding. Scientists believe his decade working in Navy engine rooms at temperatures reaching 110 degrees may have driven this accumulation. He also carries three gene variants his afflicted relatives lack. His son Brian inherited the mutation and remains asymptomatic at 43. Brian received anti-amyloid drugs in clinical trials. Researchers published their findings on Whitney in Nature Medicine. They described the study as a call for other scientists to help solve the case.

eBird, now the world's largest citizen science project with over 2 billion bird observations, is transforming ornithology by turning casual birders (and even TikTok-using kids) into vital contributors to global research and conservation. Slashdot reader alternative_right shares a report from Phys.org: The Cornell Lab of Ornithology has been one of the most influential organizations in the world when it comes to encouraging people to engage in natural history projects. While some form of amateur involvement in science projects has been around since 1900, when the Audubon Society organized the first Christmas Bird Count, it was the Cornell Lab that formalized citizen science as a sound and reliable means of collecting data on birds.

It didn't take much thought to realize that one of the richest sources of information about birds resided in the notebooks virtually every birder has kept, often from childhood. It's a given that birdwatchers list everything. The problem is that zillions of such notebooks sit forgotten in drawers or in dusty boxes in the attic. If only all of that information could be gathered together, organized in sensible ways and then made available to anyone who wanted to use it. What a resource that would be!

After lots of trials and discussion, a small team at the Lab came up with the idea of eBird. It started in a humble way back in 2002, as simply somewhere birders could store their records in a central location. Today, "humble" is no longer an appropriate description. In 2022, its 20th anniversary year, a total of more than 1.3 billion records had been received from more than 820,000 participants. In the month of August this year, reports eBird, 123,000 birders submitted 1.6 million lists of sightings. It has now hit a total of 2 billion bird observations since inception.

An anonymous reader quotes a report from The Guardian: MEPs voted on Wednesday by 355 in favor to 247 against to reserve names such as "steak", "burger" and "sausage" exclusively for products derived from meat, a longstanding demand of farm unions. In order to come into effect, the idea would have to be approved by a majority of the EU's 27 member states, which is far from certain. The vote is a victory for the French centre-right MEP Celine Imart, who drafted the amendment to legislation intended to strengthen the position of farmers in the food supply chain.

Imart, who is also a cereals farmer in north-west France, said: "A steak, an escalope or a sausage are products from our livestock, not laboratory art nor plant products. There is a need for transparency and clarity for the consumer and recognition for the work of our farmers." She argues the proposal is in line with EU rules that already ban the use of terms such as "milk" and "yoghurt" for non-dairy products.

The European parliament rejected a ban on meaty names for plant-based products in 2020, but the 2024 elections shifted the parliament to the right, bringing in more lawmakers who seek close ties with farmers. Opposition was led by Green MEPs, who decried what they saw as a populist move to rename plant-based foods. "Veggie burgers, seitan schnitzel and tofu sausage do not confuse consumers, only rightwing politicians," Thomas Waitz, an Austrian Green MEP, said after the vote. "This tactic is a diversion and a pathetic smokescreen. No farmer will earn more money or secure their future with this ban."

Amazon Pharmacy will begin offering prescription pickup kiosks at its One Medical clinics starting in Los Angeles this December, allowing patients to collect common medications like antibiotics and inhalers without waiting for delivery. Reuters reports: The kiosks will be the first in-person pick-up service offered by Amazon Pharmacy, which has been providing prescription services primarily by delivery, said Hannah McClellan Richards, a vice president at Amazon Pharmacy. One Medical offers a membership structure that allows patients to access primary and urgent care at a subscription fee of $199 annually. Patients without a membership are still able to book an appointment and would be able to use the kiosk, the company said.

Richards said in an interview that the company plans to expand the kiosk model outside of California in 2026 and is in talks with external health systems to introduce the machines through partnerships. Amazon does not plan to offer medicines that must be refrigerated, such as GLP-1 weight-loss drugs, or more tightly regulated prescriptions like controlled pain medicines through the kiosk. Inventory for each kiosk will be tailored to the provider, and patients would be able to consult a company pharmacist virtually, Amazon said in a press release.

Susumu Kitagawa, Richard Robson, and Omar M. Yaghi were awarded the Nobel Prize in Chemistry on Wednesday for the development of molecular building blocks with spaces large enough that gases and other chemicals can flow through them. The New York Times: The cavities on the inside are "almost like rooms in a hotel, so that guest molecules can enter and also exit again from the same material," Heiner Linke, chair of the Nobel Committee for Chemistry, said during the announcement of the award. The laureates' discoveries, he added, pave the way for the creation of materials that can separate toxic chemicals from wastewater or harvest water molecules in a desert.

The laureates' work started with experiments by Dr. Robson in the 1980s and gradually developed over a period of about 15 years. "It takes time for science to be recognized, and it takes multiple workers in the field with different approaches," said Dorothy Phillips, president of the American Chemical Society. The three laureates will share a prize of 11 million Swedish kronor, or around $1.17 million.

XXongo writes: A New York times article suggests that merging the diagnosis of Asperger's syndrome into the Autism diagnosis in 2013, thus creating the "autism spectrum disorder," was not helpful (paywalled; alternative source). That broadening of the diagnosis, along with the increasing awareness of the disorder, is largely responsible for the steep rise in autism cases that Health Secretary Robert F. Kennedy Jr. has called "an epidemic" and has attributed to theories of causality that mainstream scientists reject, like vaccines and, more recently, Tylenol. But the same diagnosis now applies to both people who are non-verbal, frequently engage in self-destructive behavior such as pounding their heads against the floor, and may require full-time care, but also to people who are merely somewhat socially awkward, possibly engage in repetitive behaviors, and have a narrow range of interests. "Everything changed when we included Asperger's [in the diagnosis of autism]," said Dr. Eric Fombonne, a psychiatrist and researcher at Oregon Health & Science University. He noted that in the earliest studies of autism rates, 75% of people with the diagnosis had intellectual disabilities. Now, only about a third do.

The New York Times: John Clarke, Michel H. Devoret and John M. Martinis were awarded the Nobel Prize in Physics on Tuesday in Sweden for showing that two properties of quantum mechanics, the physical laws that rule the subatomic realm, could be observed on a system large enough to see with the naked eye. They will share a prize of 11 million Swedish kroner, or around $1.17 million.

"There is no advanced technology today that does not rely on quantum mechanics," Olle Eriksson, chairman of the Nobel Committee for Physics, said during the announcement of the award. The laureates' discoveries, he added, paved the way for technologies like the cellphone, cameras and fiber optic cables.

It also helped lay the groundwork for current attempts to build a quantum computer, a device that could compute and process information at speeds that would not be possible with classical computer. Martinis worked at Google from 2014 to 2020 to build a quantum computer and led the quantum supremacy experiment in 2019. Devoret is cited in Google's recent breakthrough where its Willow quantum chip solved a problem in five minutes that the world's most advanced supercomputer could never solve.

The three laureates conducted experiments with electrical circuits that demonstrated quantum mechanical tunneling and quantized energy levels in systems large enough to hold in the hand. Clarke is a professor at the University of California, Berkeley. Devoret joined his research group in the 1980s and is now at Yale University and UC Santa Barbara. Martinis also joined the group in the 1980s and is currently at UC Santa Barbara and co-founded Qolab, a startup developing utility-scale superconducting quantum computers.

alternative_right shares a report from ScienceDaily: Scientists may have finally uncovered the mystery behind ultra-high-energy cosmic rays -- the most powerful particles known in the universe. A team from NTNU suggests that colossal winds from supermassive black holes could be accelerating these particles to unimaginable speeds. These winds, moving at half the speed of light, might not only shape entire galaxies but also fling atomic nuclei across the cosmos with incredible energy. [...]

But what on earth does that mean? The Milky Way is the neighborhood in the universe where you and I live. Our Sun and solar system are part of this galaxy, along with at least 100 billion other stars. "There is a black hole called Sagittarius-A* located right in the centre of the Milky Way. This black hole is currently in a quiet phase where it isn't consuming any stars, as there is not enough matter in the vicinity," [said postdoctoral fellow Enrico Peretti from the Universite Paris Cite]. This contrasts with growing, supermassive, active black holes that consume up to several times the mass of our own Sun each year. "A tiny portion of the material can be pushed away by the force of the black hole before it is pulled in. As a result, around half of these supermassive black holes create winds that move through the universe at up to half the speed of light," Peretti said.

We have known about these gigantic winds for approximately ten years. The winds from these black holes can affect galaxies. By blowing away gases, they can prevent new stars from forming, for example. This is dramatic enough in itself, but Oikonomou and her colleagues looked at something else, much smaller, that these winds could be the cause of." It is possible that these powerful winds accelerate the particles that create the ultra-high-energy radiation," said [lead author Domenik Ehlert]. The findings have been published in the journal Monthly Notices of the Royal Astronomical Society.