Roughly 10 to 25% of lung cancers worldwide now occur in people who have never smoked, according to researchers at the National Cancer Institute. Among certain groups of Asian and Asian American women, that share reaches 50% or more. Scientists studying 871 nonsmokers with lung cancer from around the world found that certain DNA mutations were significantly more common in people living in areas with high air pollution levels, including Hong Kong, Taiwan and Uzbekistan.

The research, published in Nature this month, revealed that pollution both directly damages DNA and causes cells to divide more rapidly. The biology of cancer in nonsmokers differs from smoking-related cases and may require different prevention and detection strategies. Nonsmokers with lung cancer are more likely to have specific "driver" mutations that can cause cancer, while smokers tend to accumulate many mutations over time.

Current U.S. screening guidelines recommend routine testing only for people ages 50 to 80 who smoked at least one pack daily for 20 years. Taiwan now offers screening for nonsmokers with family history after a nationwide trial detected cancer in 2.6% of participants.

An anonymous reader quotes a report from Phys.org: The mission team of NASA's Jupiter-orbiting Juno spacecraft executed a deep-space move in December 2023 to repair its JunoCam imager to capture photos of the Jovian moon Io. Results from the long-distance save were presented during a technical session on July 16 at the Institute of Electrical and Electronics Engineers Nuclear & Space Radiation Effects Conference in Nashville. JunoCam is a color, visible-light camera. The optical unit for the camera is located outside a titanium-walled radiation vault, which protects sensitive electronic components for many of Juno's engineering and science instruments. This is a challenging location because Juno's travels carry it through the most intense planetary radiation fields in the solar system. While mission designers were confident JunoCam could operate through the first eight orbits of Jupiter, no one knew how long the instrument would last after that. Throughout Juno's first 34 orbits (its prime mission), JunoCam operated normally, returning images the team routinely incorporated into the mission's science papers. Then, during its 47th orbit, the imager began showing hints of radiation damage. By orbit 56, nearly all the images were corrupted.

While the team knew the issue might be tied to radiation, pinpointing what was specifically damaged within JunoCam was difficult from hundreds of millions of miles away. Clues pointed to a damaged voltage regulator that was vital to JunoCam's power supply. With few options for recovery, the team turned to a process called annealing, where a material is heated for a specified period before slowly cooling. Although the process is not well understood, the idea is that heating can reduce defects in the material. Soon after the annealing process finished, JunoCam began cranking out crisp images for the next several orbits. But Juno was flying deeper and deeper into the heart of Jupiter's radiation fields with each pass. By orbit 55, the imagery had again begun showing problems.

"After orbit 55, our images were full of streaks and noise," said JunoCam instrument lead Michael Ravine of Malin Space Science Systems. "We tried different schemes for processing the images to improve the quality, but nothing worked. With the close encounter of Io bearing down on us in a few weeks, it was Hail Mary time: The only thing left we hadn't tried was to crank JunoCam's heater all the way up and see if more extreme annealing would save us." Test images sent back to Earth during the annealing showed little improvement in the first week. Then, with the close approach of Io only days away, the images began to improve dramatically. By the time Juno came within 930 miles (1,500 kilometers) of the volcanic moon's surface on Dec. 30, 2023, the images were almost as good as the day the camera launched, capturing detailed views of Io's north polar region that revealed mountain blocks covered in sulfur dioxide frosts rising sharply from the plains and previously uncharted volcanoes with extensive flow fields of lava. To date, the solar-powered spacecraft has orbited Jupiter 74 times. Recently, the image noise returned during Juno's 74th orbit.

An anonymous reader shares a report: In 2023 and 2024, the hottest years on record, more than 78 million acres of forests burned around the globe. The fires sent veils of smoke and several billion tons of carbon dioxide into the atmosphere, subjecting millions of people to poor air quality. Extreme forest-fire years are becoming more common because of climate change, new research suggests.

"Climate change is loading the dice for extreme fire seasons like we've seen," said John Abatzoglou, a climate scientist at the University of California Merced. "There are going to be more fires like this." The area of forest canopy lost to fire during 2023 and 2024 was at least two times greater than the annual average of the previous nearly two decades, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences.

The researchers used imagery from the LANDSAT satellite network to determine how tree cover had changed from 2002 to 2024, and compared that with satellite detections of fire activity to see how much canopy loss was because of fire. Globally, the area of land burned by wildfires has decreased in recent decades, mostly because humans are transforming savannas and grasslands into less flammable landscapes. But the area of forests burned has gone up.

At least 759 US hospitals experienced network disruptions during the CrowdStrike outage on July 19, 2024, with more than 200 suffering outages that directly affected patient care services, according to a study published in JAMA Network Open by UC San Diego researchers. The researchers detected disruptions across 34% of the 2,232 hospital networks they scanned, finding outages in health records systems, fetal monitoring equipment, medical imaging storage, and patient transfer platforms.

Most services recovered within six hours, though some remained offline for more than 48 hours. CrowdStrike dismissed the study as "junk science," arguing the researchers failed to verify whether affected networks actually ran CrowdStrike software. The researchers defended their methodology, noting they could scan only about one-third of America's hospitals, suggesting the actual impact may have been significantly larger.

An anonymous reader shares a blog post: The International Mathematical Olympiad is the world's most prestigious competition for young mathematicians, and has been held annually since 1959. Each country taking part is represented by six elite, pre-university mathematicians who compete to solve six exceptionally difficult problems in algebra, combinatorics, geometry, and number theory. Medals are awarded to the top half of contestants, with approximately 8% receiving a prestigious gold medal.

Recently, the IMO has also become an aspirational challenge for AI systems as a test of their advanced mathematical problem-solving and reasoning capabilities. Last year, Google DeepMind's combined AlphaProof and AlphaGeometry 2 systems achieved the silver-medal standard, solving four out of the six problems and scoring 28 points. Making use of specialist formal languages, this breakthrough demonstrated that AI was beginning to approach elite human mathematical reasoning.

This year, we were amongst an inaugural cohort to have our model results officially graded and certified by IMO coordinators using the same criteria as for student solutions. Recognizing the significant accomplishments of this year's student-participants, we're now excited to share the news of Gemini's breakthrough performance. An advanced version of Gemini Deep Think solved five out of the six IMO problems perfectly, earning 35 total points, and achieving gold-medal level performance.

"Scientists at the world's largest particle collider have observed a new class of antimatter particles breaking down at a different rate than their matter counterparts," reports Scientific American: [P]hysicists have been on the hunt for any sign of difference between matter and antimatter, known in the field as a violation of "charge conjugation-parity symmetry," or CP violation, that could explain why some matter escaped destruction in the early universe. [Wednesday] physicists at the Large Hadron Collider (LHC)'s LHCb experiment published a paper in the journal Nature announcing that they've measured CP violation for the first time in baryons — the class of particles that includes the protons and neutrons inside atoms.

Baryons are all built from triplets of even smaller particles called quarks. Previous experiments dating back to 1964 had seen CP violation in meson particles, which unlike baryons are made of a quark-antiquark pair. In the new experiment, scientists observed that baryons made of an up quark, a down quark and one of their more exotic cousins called a beauty quark decay more often than baryons made of the antimatter versions of those same three quarks... The matter-antimatter difference scientists observed in this case is relatively small, and it fits within predictions of the Standard Model of particle physics — the reigning theory of the subatomic realm. This puny amount of CP violation, however, cannot account for the profound asymmetry between matter and antimatter we see throughout space...

"We are trying to find little discrepancies between what we observe and what is predicted by the Standard Model," [says LHCb spokesperson/study co-author Vincenzo Vagnoni of the Italian National Institute of Nuclear Physics]. "If we find a discrepancy, then we can pinpoint what is wrong." The researchers hope to discover more cracks in the Standard Model as the experiment keeps running. Eventually LHCb should collect about 30 times more data than was used for this analysis, which will allow physicists to search for CP violation in particle decays that are even rarer than the one observed here.

So stay tuned for an answer to why anything exists at all.

"The distant reaches of the Solar System are still mysterious," writes ScienceAlert. "Not much sunlight pierces these regions, and there are strong hints that undiscovered objects lurk there. The objects that astronomers have discovered in these dim reaches are primordial, and their orbits suggest the presence of more undiscovered objects."

And now thanks to the giant 8.2-meter Subaru telescope at Hawaii's Mauna Kea Observatory, astronomers have discovered "a massive new solar system body located beyond the orbit of Pluto," reports Space.com. The weird elongated orbit of the object suggests that if "Planet Nine" exists, it is much further from the sun than thought, or it has been ejected from our planetary system altogether.

The strange orbit of the object, designated 2023 KQ14 and nicknamed "Ammonite," classifies it as a "sednoid." Sednoids are bodies beyond the orbit of the ice giant Neptune, known as trans-Neptunian objects (TNOs), characterized by a highly eccentric (non-circular) orbit and a distant closest approach to the sun or "perihelion." The closest distance that 2023 KQ14 ever comes to our star is equivalent to 71 times the distance between Earth and the sun... This is just the fourth known sednoid, and its orbit is currently different from that of its siblings, though it seems to have been stable for 4.5 billion years.

However, the team behind the discovery, made using Subaru Telescope as part of the Formation of the Outer Solar System: An Icy Legacy (FOSSIL) survey, thinks that all four sednoids were on similar orbits around 4.2 billion years ago. That implies something dramatic happened out at the edge of the solar system around 400 million years after its birth. Not only does the fact that 2023 KQ14 now follows a unique orbit suggest that the outer solar system is more complex and varied than previously thought, but it also places limits on a hypothetical "Planet Nine" theorized to lurk at the edge of the solar system.
There's "no viable transfer mechanisms" to explain the observed orbits "with the current configuration of planets," according to the team's recently-published paper. But since those orbits are stable, it "suggests that an external gravitational influence beyond those of the currently known Solar System planets is required to form their orbits." So where does that leave us? ScienceAlert summarizes the rest of the paper — and where things stand now: Astronomers have proposed many sources for this external gravitational influence, including interactions with a rogue planet or star, ancient stellar interactions from when the Sun was still in its natal cluster, and the capture of objects from other lower-mass stars in the Solar System's early times. But the explanation that gets the most attention is interactions with a hypothetical planet, Planet Nine.

If Planet Nine exists, it has a huge area to hide in. Some astronomers who have studied its potential existence think it could be the fifth largest planet in the Solar System. It would be so far away that it would be extremely dim. However, we may be on the cusp of detecting it, if it exists. The Vera Rubin Observatory recently saw first light and will begin its decade-long Legacy Survey of Space and Time (LSST). The LSST will find transient events and objects in the Solar System like no other telescope before it. It's purpose-built to find hard-to-detect objects, and not even an elusive object like Planet Nine may be able to hide from it.

San Francisco-based startup Orchid Health "screens embryos for thousands of potential future illnesses," reports the Washington Post, calling it "the first company to say it can sequence an embryo's entire genome of 3 billion base pairs." It uses as few as five cells from an embryo to test for more than 1,200 of these uncommon single-gene-derived, or monogenic, conditions. The company also applies custom-built algorithms to produce what are known as polygenic risk scores, which are designed to measure a future child's genetic propensity for developing complex ailments later in life, such as bipolar disorder, cancer, Alzheimer's disease, obesity and schizophrenia. Orchid, [founder Noor] Siddiqui said in a tweet, is ushering in "a generation that gets to be genetically blessed and avoid disease." Right now, at $2,500 per embryo-screening on top of the average $20,000 for a single cycle of IVF, Siddiqui's social network in Silicon Valley and other tech hubs is an ideal target market...

Yet several genetic scientists told The Post they doubt Orchid's core claim: that it can accurately sequence an entire human genome from just five cells collected from an early-stage embryo, enabling it to see many more single- and multiple-gene-derived disorders than other methods have. Experts have struggled to extract accurate genetic information from small embryonic samples, said Svetlana Yatsenko, a Stanford University pathology professor who specializes in clinical and research genetics. Genetic tests that use saliva or blood samples typically collect hundreds of thousands of cells. For its vastly smaller samples, Orchid uses a process called amplification, which creates copies of the DNA retrieved from the embryo. That process, Yatsenko said, can introduce major inaccuracies. "You're making many, many mistakes in the amplification," she said, rendering it problematic to declare any embryo free of a particular disease, or positive for one. "It's basically Russian roulette...."

Numerous fertility doctors and scientists also told The Post they have serious reservations about screening embryos through polygenic risk scoring, the technique that allows Orchid and other companies to predict future disease by tying clusters of hundreds or even thousands of genes to disease outcomes and in some cases to other traits, such as intelligence and height. The vast majority of diseases that afflict humans are associated with many different genes rather than a single gene... And for traits such as intelligence, polygenic scoring has almost negligible predictive capacity — just a handful of IQ points... Or parents might select against an unwanted trait, such as schizophrenia, without understanding how they may be screening out desired traits associated with the same genes, such as creativity... The American College of Medical Genetics and Genomics calls the benefits of screening embryos for polygenic risks "unproven" and warns that such tests "should not be offered" by clinicians. A pioneer of polygenic risk scores, Harvard epidemiology professor Peter Kraft, has criticized Orchid, saying on X that "the science doesn't add up" and that "waving a magic wand and changing some of these variants at birth may not do anything at all."
The article notes several startups are already providing predictions on intelligence. "In the United States, there are virtually no restrictions on the types of genetic predictions companies can offer, and no external vetting of their proprietary scoring methods."

"Eight healthy babies were born in Britain," reports Phys.org, "with the help of an experimental technique that uses DNA from three people to help mothers avoid passing devastating rare diseases to their children, researchers reported Wednesday."

Mutations in mitochondrial DNA "can cause a range of diseases in children that can lead to muscle weakness, seizures, developmental delays, major organ failure and death," and in rare cases even pre-IVF testing can't clearly detect their presence. Researchers have been developing a technique that tries to avoid the problem by using the healthy mitochondria from a donor egg. They reported in 2023 that the first babies had been born using this method... Using this method means the embryo has DNA from three people — from the mother's egg, the father's sperm and the donor's mitochondria — and it required a 2016 U.K. law change to approve it. It is also allowed in Australia but not in many other countries, including the U.S. Experts at Britain's Newcastle University and Monash University in Australia reported in the New England Journal of Medicine Wednesday that they performed the new technique in fertilized embryos from 22 patients, which resulted in eight babies that appear to be free of mitochondrial diseases. One woman is still pregnant...

Robin Lovell-Badge [a stem cell and developmental genetics scientist at the Francis Crick Institute who was not involved in the research] said the amount of DNA from the donor is insignificant, noting that any resulting child would have no traits from the woman who donated the healthy mitochondria...

In the U.K., every couple seeking a baby born through donated mitochondria must be approved by the country's fertility regulator. As of this month, 35 patients have been authorized to undergo the technique. Critics have previously raised concerns, warning that it's impossible to know the impact these sorts of novel techniques might have on future generations... But in countries where the technique is allowed, advocates say it could provide a promising alternative for some families.

"Nearly 2 million people protected their privacy by deleting their DNA from 23andMe after it declared bankruptcy in March," writes a Washington Post technology columnist.

"Now it's back with the same person in charge — and I still don't trust it." As of this week, genetic data from the more than 10 million remaining 23andMe customers has been formally sold to an organization called TTAM Research Institute for $305 million. That nonprofit is run by the person who co-founded and ran 23andMe, Anne Wojcicki. In a recent email to customers, the new 23andMe said it "will be operating with the same employees and privacy protocols that have protected your data." Never mind that Wojcicki and her privacy protocols are what put your DNA at risk in the first place...

The company is legally obligated to maintain and honor 23andMe's existing privacy policies, user consents and data protection measures. And as part of a settlement with states, TTAM also agreed to provide annual privacy reports to state regulators and set up a privacy board. But it hasn't agreed to take the fundamental step of asking for permission to acquire existing customers' genetic information. And it's leaving the door open to selling people's genes to the highest bidder again in the future...

Existing 23andMe customers have the right to delete their data or opt out of TTAM's research. But the new company is not asking for opt-in permission before it takes ownership of customers' DNA... Why does that matter? Because people who handed over the DNA 15 years ago, often to learn about their genetic ancestry, never imagined it might be used in this way now. Asking for new permission might significantly shrink the size (and value) of 23andMe's DNA database — but it would be the right thing to do given the rocky history. Neil M. Richards [the Washington University professor who served as privacy ombudsman for the bankruptcy court], pointed out that about a third of 23andMe customers haven't logged in for at least three years, so they may have no idea what is going on. Some 23andMe users never even clicked "agree" on a legal agreement that allowed their data to be sold like this; the word "bankruptcy" wasn't added to the company's privacy policy until 2022. And then there is an unknown number of deceased users who most certainly can't consent, but whose DNA still has an impact on their living genetic relatives...

[S]everal states have argued that their existing genetic privacy laws don't allow 23andMe to receive the information without getting permission from every single person. Virginia has an ongoing lawsuit over the issue, and the California attorney general's office told me it "will continue to fight to protect and vindicate the rights" of consumers....
Two more points of concern:

• "There is nothing in 23andMe's bankruptcy agreement or privacy statement to prevent TTAM from selling or transferring DNA to some other organization in the future."

• The article also notes a 2023 data breach affecting 6.9 million users, arguing "They haven't shown they can keep your data safe... 23andMe's financial struggles could make it hard to run a robust cybersecurity program."

Historian Garrett M. Graff describes his upcoming book, The Devil Reached Toward the Sky: An Oral History of the Making and Unleashing of the Atomic Bomb. "I assembled an oral history of the Manhattan Project, the bombings of Hiroshima and Nagasaki and the end of World War II in the Pacific, told through the voices of around 500 participants and witnesses of the events — including luminaries like Albert Einstein and Oppenheimer and political figures like President Harry Truman."

It was 80 years ago this week that physicists and 150 other leaders in the atomic bomb program "gathered in the desert outside Alamogordo, New Mexico, for the world's first test of a nuclear explosion." In an except from his upcoming book, Graff publishes quotes from eyewitness: Brig. Gen. Leslie Groves: I had become a bit annoyed with Fermi when he suddenly offered to take wagers from his fellow scientists on whether or not the bomb would ignite the atmosphere, and if so, whether it would merely destroy New Mexico or destroy the world. He had also said that after all it wouldn't make any difference whether the bomb went off or not because it would still have been a well worthwhile scientific experiment. For if it did fail to go off, we would have proved that an atomic explosion was not possible. Afterward, I realized that his talk had served to smooth down the frayed nerves and ease the tension of the people at the base camp, and I have always thought that this was his conscious purpose. Certainly, he himself showed no signs of tension that I could see...

As the hour approached, we had to postpone the test — first for an hour and then later for 30 minutes more — so that the explosion was actually three- and one-half hours behind the original schedule... Our preparations were simple. Everyone was told to lie face down on the ground, with his feet toward the blast, to close his eyes and to cover his eyes with his hands as the countdown approached zero. As soon as they became aware of the flash they could turn over and sit or stand up, covering their eyes with the smoked glass with which each had been supplied... The quiet grew more intense. I, myself, was on the ground between Bush and Conant...

Edward Teller: We all were lying on the ground, supposedly with our backs turned to the explosion. But I had decided to disobey that instruction and instead looked straight at the bomb. I was wearing the welder's glasses that we had been given so that the light from the bomb would not damage our eyes. But because I wanted to face the explosion, I had decided to add some extra protection. I put on dark glasses under the welder's glasses, rubbed some ointment on my face to prevent sunburn from the radiation, and pulled on thick gloves to press the welding glasses to my face to prevent light from entering at the sides... We all listened anxiously as the broadcast of the final countdown started; but, for whatever reason, the transmission ended at minus five seconds...

Kenneth T. Bainbridge: My personal nightmare was knowing that if the bomb didn't go off or hang-fired, I, as head of the test, would have to go to the tower first and seek to find out what had gone wrong...

Brig. Gen. Thomas F. Farrell: Dr. Oppenheimer held on to a post to steady himself. For the last few seconds, he stared directly ahead.
A few examples of how they remembered the explosion:

• William L. Laurence: There rose from the bowels of the earth a light not of this world, the light of many suns in one.

• Kenneth T. Bainbridge: I felt the heat on the back of my neck, disturbingly warm.

• George B. Kistiakowsky: I am sure that at the end of the world — in the last millisecond of the earth's existence — the last man will see what we have just seen.

• Brig. Gen. Thomas F. Farrell: Oppenheimer's face relaxed into an expression of tremendous relief.

• J. Robert Oppenheimer: We knew the world would not be the same. A few people laughed, a few people cried.

• Norris Bradbury, physicist, Los Alamos Lab: Some people claim to have wondered at the time about the future of mankind. I didn't. We were at war, and the damned thing worked.

At Sotheby's Geek Week auction, the largest known Martian meteorite on Earth sold for a record-breaking $5.3 million. The Associated Press reports: The 54-pound (25-kilogram) rock named NWA 16788 was discovered in the Sahara Desert in Niger by a meteorite hunter in November 2023, after having been blown off the surface of Mars by a massive asteroid strike and traveling 140 million miles (225 million kilometers) to Earth, according to Sotheby's. The estimated sale price before the auction was $2 million to $4 million. The identity of the buyer was not immediately disclosed. The final bid was $4.3 million. Adding various fees and costs, the official sale price was about $5.3 million, making it the most valuable meteorite ever sold at auction, Sotheby's said.

The live bidding was slow, with the auctioneer trying to coax more offers and decreasing the minimum bid increases. [...] The bidding for the Mars meteorite began with two advance offers of $1.9 million and $2 million. The live bidding slowly proceeded with increases of $200,000 and $300,000 until $4 million, then continued with $100,000 increases until reaching $4.3 million. The red, brown and gray meteorite is about 70% larger than the next largest piece of Mars found on Earth and represents nearly 7% of all the Martian material currently on this planet, Sotheby's says. It measures nearly 15 inches by 11 inches by 6 inches (375 millimeters by 279 millimeters by 152 millimeters). It was also a rare find. There are only 400 Martian meteorites out of the more than 77,000 officially recognized meteorites found on Earth, the auction house says.

An anonymous reader quotes a report from Live Science: In a world first, scientists have demonstrated an enigmatic phenomenon in quantum computing that could pave the way for fault-tolerant machines that are far more powerful than any supercomputer. The process, called "magic state distillation," was first proposed 20 years ago, but its use in logical qubits has eluded scientists ever since. It has long been considered crucial for producing the high-quality resources, known as "magic states," needed to fulfill the full potential of quantum computers. [...] Now, however, scientists with QuEra say they have demonstrated magic state distillation in practice for the first time on logical qubits. They outlined their findings in a new study published July 14 in the journal Nature.

In the study, using the Gemini neutral-atom quantum computer, the scientists distilled five imperfect magic states into a single, cleaner magic state. They performed this separately on a Distance-3 and a Distance-5 logical qubit, demonstrating that it scales with the quality of the logical qubit. "A greater distance means better logical qubits. A Distance-2, for instance, means that you can detect an error but not correct it. Distance-3 means that you can detect and correct a single error. Distance-5 would mean that you can detect and correct up to two errors, and so on, and so on," [explained Yuval Boger, chief commercial officer at QuEra who was not personally involved in the research]. "So the greater the distance, the higher fidelity of the qubit is -- and we liken it to distilling crude oil into a jet fuel."

As a result of the distillation process, the fidelity of the final magic state exceeded that of any input. This proved that fault-tolerant magic state distillation worked in practice, the scientists said. This means that a quantum computer that uses both logical qubits and high-quality magic states to run non-Clifford gates is now possible. "We're seeing sort of a shift from a few years ago," Boger said. "The challenge was: can quantum computers be built at all? Then it was: can errors be detected and corrected? Us and Google and others have shown that, yes, that can be done. Now it's about: can we make these computers truly useful? And to make one computer truly useful, other than making them larger, you want them to be able to run programs that cannot be simulated on classical computers."

alternative_right shares a report from ScienceAlert: Around a Sun-like star just 1,300 light-years away, a family of planets has been seen in its earliest moments of conception. Astronomers analyzed the infrared flow of dust and detritus left over from the formation of a baby star called HOPS-315, finding tiny concentrations of hot minerals that will eventually form planetesimals -- the 'seeds' around which new planets will grow. It's a system that can tell us about the very first steps of planet formation, and may even contain clues about how our own Solar System formed. The findings have been published in the journal Nature.

Cancer death rates in the U.S. have fallen by approximately one-third since the 1990s when adjusted for age, according to data cited in a new analysis of global cancer trends. The decline represents a steady, year-over-year reduction that began in the early 1990s and continues across developed countries.

Prevention efforts have contributed substantially to the decline. Reduced smoking rates in wealthy nations prevented more than 3 million cancer deaths since 1975 in America alone. Britain's HPV vaccination program, launched in 2008 for teenage girls, produced a 90% reduction in cervical cancer rates among women in their 20s within 15 years. Treatment advances have transformed outcomes for specific cancers. Childhood leukemia, once virtually fatal, now has a five-year survival rate above 90%.

Researchers have identified inexpensive drugs with cancer-prevention properties, including aspirin, which cuts bowel cancer risk in half for patients with Lynch syndrome. Future progress faces obstacles, however, including high treatment costs and planned cuts to the National Cancer Institute under the Trump administration. China overtook America as the primary source of cancer research in 2025.

Airbus's Silicon Valley innovation center Acubed and Google spinout SandboxAQ have successfully tested a quantum-sensing navigation device as an alternative to GPS during 150 hours of flights across the continental United States. The toaster-sized MagNav device uses quantum physics to measure unique magnetic signatures in Earth's crust [non-paywalled, syndicated link], with an AI algorithm matching those signatures to exact locations.

The technology achieved Federal Aviation Administration requirements by pinpointing aircraft location within two nautical miles 100% of the time and within 550 meters 64% of the time. SandboxAQ CEO Jack Hidary called it "the first novel absolute navigation system to our knowledge in the last 50 years." The analog system cannot be jammed or spoofed like GPS, which faces increasing tampering in the Middle East and around Ukraine and Russia.

NIST: There's a new record holder for the most accurate clock in the world. Researchers at the National Institute of Standards and Technology (NIST) have improved their atomic clock based on a trapped aluminum ion. Part of the latest wave of optical atomic clocks, it can perform timekeeping with 19 decimal places of accuracy.

Optical clocks are typically evaluated on two levels -- accuracy (how close a clock comes to measuring the ideal "true" time, also known as systematic uncertainty) and stability (how efficiently a clock can measure time, related to statistical uncertainty). This new record in accuracy comes out of 20 years of continuous improvement of the aluminum ion clock. Beyond its world-best accuracy, 41% greater than the previous record, this new clock is also 2.6 times more stable than any other ion clock. Reaching these levels has meant carefully improving every aspect of the clock, from the laser to the trap and the vacuum chamber.

The team published its results in Physical Review Letters. "It's exciting to work on the most accurate clock ever," said Mason Marshall, NIST researcher and first author on the paper. "At NIST we get to carry out these long-term plans in precision measurement that can push the field of physics and our understanding of the world around us."

The LIGO-Virgo-KAGRA Collaboration has detected the most massive black hole merger to date, forming a final black hole around 225 times the Sun's mass. Caltech reports: Before now, the most massive black hole merger -- produced by an event that took place in 2021 called GW190521 -- had a total mass of 140 times that of the Sun. In the more recent GW231123 event, the 225-solar-mass black hole was created by the coalescence of black holes each approximately 100 and 140 times the mass of the Sun. In addition to their high masses, the black holes are also rapidly spinning.

"The black holes appear to be spinning very rapidly -- near the limit allowed by Einstein's theory of general relativity," explains Charlie Hoy of the University of Portsmouth and a member of the LVK. "That makes the signal difficult to model and interpret. It's an excellent case study for pushing forward the development of our theoretical tools." Researchers are continuing to refine their analysis and improve the models used to interpret such extreme events. "It will take years for the community to fully unravel this intricate signal pattern and all its implications," says Gregorio Carullo of the University of Birmingham and a member of the LVK. "Despite the most likely explanation remaining a black hole merger, more complex scenarios could be the key to deciphering its unexpected features. Exciting times ahead!"

Armagh Observatory is marking a very special meteorological milestone as the institute celebrates 230 years of continuous weather observation. From a report: The unbroken tradition of handwritten data makes it the longest sequence of continuous weather information gathered anywhere in the UK and Ireland. Events are being held at Armagh Observatory on Monday to mark the significant anniversary. Nowadays, most weather data is gathered only by automated weather stations, but not in Armagh, where the human touch remains.

The first handwritten recording was made on the evening of 14 July 1795, when a measurement of the temperature and air pressure was recorded on a graph at the observatory that sits above the city of Armagh. The measurement was repeated the next day and every subsequent day for the next 230 years.

A scientific paper featuring an AI-generated image of a rat with an oversized penis was retracted three days after publication, highlighting broader problems plaguing academic publishing as researchers struggle with an explosion of scientific literature. The paper appeared in Frontiers in Cell and Developmental Biology before widespread mockery forced its withdrawal.

Research studies indexed on Clarivate's Web of Science database increased 48% between 2015 and 2024, rising from 1.71 million to 2.53 million papers. Nobel laureate Venki Ramakrishnan called the publishing system "broken and unsustainable," while University of Exeter researcher Mark Hanson described scientists as "increasingly overwhelmed" by the volume of articles. The Royal Society plans to release a major review of scientific publishing disruptions at summer's end, with former government chief scientist Mark Walport citing incentives that favor quantity over quality as a fundamental problem.