This winter's flu vaccine was a particularly bad match for the most common influenza strain in circulation, a new analysis from the Centers for Disease Control and Prevention found. Gizmodo reports: Thankfully, the flu season was much milder than usual for the second year in a row, as ongoing covid-19 precautions likely blunted the spread of flu as well. The estimates come from the CDC's long-running surveillance program of people with suspected flu-like symptoms who visit various outpatient sites throughout the country. Overall, the odds of catching a case of confirmed flu were only slightly lower for vaccinated people, the researchers found. Against all flu strains detected at these sites, the vaccine was deemed to be 14% effective, as well as 16% effective at preventing cases of flu from A(H3N2) viruses, the predominant strain this winter. Numbers this low are far below the 50% threshold for a vaccine to be considered relatively useful, and they're not even high enough to reach statistical significance.

In the words of the researchers, who published their results in the CDC's Morbidity and Mortality Weekly Report, the vaccine "did not reduce the risk for outpatient respiratory illness caused by influenza A(H3N2) viruses that have predominated so far this season." Flu vaccines, even in a good year, are far from perfect. The strains of influenza virus that infect humans are constantly evolving, meaning that scientists have to try to predict what these strains will look like during the next flu season so that they can match them to the strains included in the vaccine (the vaccine will usually include four strains at a time). This guessing game often results in a vaccine that's around 50% to 60% effective, but sometimes, as is the case this year, the mismatch can get worse. It doesn't help that this year's main flu is H3N2, a subtype of flu already known for being harder to predict than others.

Today, March 11, 2022, marks two years since covid-19 was declared a pandemic by the World Health Organization. We've had lockdowns, vaccines, and arguments about how to move forward and live with this virus. We've watched the pandemic through numbers and data and memorials to the many lives lost, officially now over six million. It is likely this figure is a vast undercount. A study published in The Lancet this week estimated that the true number may be three times higher, at 18.2 million. Technology Review: And, in a statement marking the two-year anniversary, WHO director-general Tedros Adhanom Ghebreyesus warned: "Although reported cases and deaths are declining globally, and several countries have lifted restrictions, the pandemic is far from over -- and it will not be over anywhere until it's over everywhere."

Researchers have categorised more than 80,000 plant species worldwide and found that most of them will "lose" in the face of humanity -- going extinct because people don't need them. From a report: This means that plant communities of the future will be hugely more homogenised than those of today, according to the paper published in the journal Plants, People, Planet. The findings, which paint a stark picture of the threat to biodiversity, cover less than 30% of all known plant species, and as such are a "wake-up call," say the researchers, highlighting the need for more work in this field. "We're actually beginning to quantify what's going to make it through the bottleneck of the Anthropocene, in terms of numbers," said John Kress, botany curator emeritus at the Smithsonian's National Museum of Natural History and lead author of the paper. "It's not the future, it's happening. The bottleneck is starting to happen right now. And I think that's part of the wake-up call that we are trying to give here. It's something we might be able to slow down a little bit, but it's happening."

The World Health Organization advised Ukraine to destroy high-threat pathogens housed in the country's public health laboratories to prevent "any potential spills" that would spread disease among the population, the agency told Reuters on Thursday. From the report: Biosecurity experts say Russia's movement of troops into Ukraine and bombardment of its cities have raised the risk of an escape of disease-causing pathogens, should any of those facilities be damaged. Like many other countries, Ukraine has public health laboratories researching how to mitigate the threats of dangerous diseases affecting both animals and humans including, most recently, COVID-19. Its labs have received support from the United States, the European Union and the WHO.

In response to questions from Reuters about its work with Ukraine ahead of and during Russia's invasion, the WHO said in an email that it has collaborated with Ukrainian public health labs for several years to promote security practices that help prevent "accidental or deliberate release of pathogens." "As part of this work, WHO has strongly recommended to the Ministry of Health in Ukraine and other responsible bodies to destroy high-threat pathogens to prevent any potential spills," the WHO, a United Nations agency, said. The WHO would not say when it had made the recommendation nor did it provide specifics about the kinds of pathogens or toxins housed in Ukraine's laboratories. The agency also did not answer questions about whether its recommendations were followed. On Wednesday, Russian's foreign ministry claimed that the U.S. operates a biowarfare lab in Ukraine, "an accusation that has been repeatedly denied by Washington and Kyiv," reports Reuters. A spokesperson for the ministry went on to claim that Russian forces unearthed documents in Ukraine that showed "an emergency attempt to erase evidence of military biological programs" by destroying lab samples.

Not only has Ukraine denied these allegations, Pentagon spokesperson John Kirby called them "laughable" and suggested Moscow could be laying the groundwork to use a chemical or biological weapon.

An anonymous reader shares a report: In 2018, an international team of scientists announced a startling discovery: Buried beneath the thick ice of the Hiawatha Glacier in northwest Greenland is an impact crater 31 kilometers wide -- not as big as the crater from the dinosaur-killing impact 66 million years ago, but perhaps still big enough to mess with the climate. Scientists were especially excited by hints in the crater and the surrounding ice that the Hiawatha strike was recent -- perhaps within the past 100,000 years, when humans might have been around to witness it. But now, using dates gleaned from tiny mineral crystals in rocks shocked by the impact, the same team says the strike is much, much older. The researchers say it occurred 58 million years ago, a warm time when vast forests covered Greenland -- and humanity was not yet even a glimmer in evolution's eye.

Kurt Kjaer, a geologist at the Natural History Museum of Denmark and a co-author of the new study, says the new date is at odds with the team's initial impression, gleaned from ice-penetrating radar. "But this is the way science works and should work," he says. The date is a blow to a group of scientists that for more than a decade has advanced a controversial hypothesis that the Younger Dryas, a drastic, 1000-year cooling about 12,800 years ago, was triggered when a comet struck Earth. They had seized on the first Hiawatha paper as a smoking gun: The crater seemed about the right age, and it was in the right place -- near a region of the North Atlantic Ocean that heavily influences Northern Hemisphere climate. Now, says Brandon Johnson, a co-author and impact modeler at Purdue University, West Lafayette, "It's probably safe to put the Younger Dryas impact hypothesis back to rest for a while."

Scientists at NASA's Johnson Space Center in Houston are preparing to open the first tube that one of the astronauts on the Apollo missions hammered into the surface of the moon. As NPR reports, it's "remained tightly sealed all these years since that 1972 Apollo 17 mission -- the last time humans set foot on the moon." From the report: The unsealed tube from that mission was opened in 2019. The layers of lunar soil had been preserved, and the sample offered insight into subjects like landslides in airless places. Because the sample being opened now has been sealed, it may contain something in addition to rocks and soil: gas. The tube could contain substances known as volatiles, which evaporate at normal temperatures, such as water ice and carbon dioxide. The materials at the bottom of the tube were extremely cold at the time they were collected. The amount of these gases in the sample is expected to be very low, so scientists are using a special device called a manifold, designed by a team at Washington University in St. Louis, to extract and collect the gas.

Another tool was developed at the European Space Agency (ESA) to pierce the sample and capture the gases as they escape. Scientists there have called that tool the "Apollo can opener." The careful process of opening and capturing has begun, and so far, so good: the seal on the inner sample tube seems to be intact. Now, the piercing process is underway, with that special "can opener" ready to trap whatever gases might come out. If there are gases in the sample, scientists will be able to use modern mass spectrometry technology to identify them. (Mass spectrometry is a tool for analyzing and measuring molecules.) The gas could also be divided into tiny samples for other researchers to study.

An anonymous reader quotes a report from Science.org: An extinct rat that once lived on an island in the Indian Ocean may have put the kibosh on scientists' dreams of resurrecting more famous extinct animals like the woolly mammoth. The Christmas Island rat disappeared just over 100 years ago, but researchers now say even its detailed genome isn't complete enough to bring it back to life. The work "shows both how wonderfully close -- and yet -- how devastatingly far" scientists are from being able to bring back extinct species by genetically transforming a close relative in what's called "de-extinction," says Douglas McCauley, an ecologist at the University of California, Santa Barbara, who was not involved with the study. [...] To bring back an extinct species, scientists would first need to sequence its genome, then edit the DNA of a close living relative to match it. Next comes the challenge of making embryos with the revised genome and bringing them to term in a living surrogate mother. So far, scientists have sequenced the genomes of about 20 extinct species, including a cave bear, passenger pigeon, and several types of mammoths and moas. But no one has yet reported re-creating the extinct genome in a living relative.

In the new study, Tom Gilbert, an evolutionary geneticist at the University of Copenhagen, thought it best to start small. "If we want to try something so crazy, why not start with a simple model," he reasoned. So, he, Jian-Qing Lin, a molecular biologist at Shantou University, and their colleagues, focused on the Christmas Island rat (Rattus macleari), which disappeared by 1908 from that island, located about 1200 kilometers west of Australia. This species "should be a dreamy candidate for de-extinction," McCauley says, given its close relationship with the Norway rat, a well-studied lab animal with a complete genome sequence that scientists already know how to modify.

Gilbert and Lin extracted DNA from the skins of two preserved Christmas Island rats and sequenced it many times over to get as much of the genome as possible. They achieved more than 60 times' coverage of it. Old DNA only survives in small fragments, so the team used the genome of the Norway rat as a reference to piece together as much as possible of the vanished rat's genome. Comparing the two genomes revealed almost 5% of the Christmas Island rat's genome was still missing, Lin, Gilbert, and their colleagues report today in Current Biology. The lost sequences included bits of about 2500 of the rat's estimated 34,000 genes. "I was surprised," Gilbert says. The recovered DNA included the genes for the Christmas Island rat's characteristic rounded ears, for example, but important immune system and olfaction genes were either missing or incomplete. The work "really highlights the difficulties, maybe even the ridiculousness, of [de-extinction] efforts," says Victoria Herridge, an evolutionary biologist at the Natural History Museum in London. Herridge says many of the missing genes make each species unique. It's also worth noting that the human genome differs by just 1% from those of chimps and bonobos.

Others researchers like Andrew Pask, a developmental biologist at the University of Melbourne, Parkville, says that the missing 5% of an extinct animal's genome likely won't affect how the transformed animal looks or behaves.

If Congress' sweeping new spending bill is signed, it would finally provide full funding to some major NASA projects that have been underfunded over the last few years. From a report: Notably, NASA's program to develop a new human lunar lander would be fully funded as the president's budget requested, as will a program to develop new commercial space stations in low Earth orbit. Overall, NASA would receive $24.041 billion for 2022 in this new bill, which will fund the US government for fiscal year 2022. NASA's portion is roughly $800 million less than the $24.8 billion that President Joe Biden's budget request called for in May of 2021. However, NASA would still see a slight bump from its total funding for fiscal year 2021, which sat at $23.27 billion.

Though Congress's plan would not fully meet the president's budget request, there are a few projects that House and Senate lawmakers are finally agreeing to fund in their entirety. The bill would give NASA's human landing system the full $1.195 billion that the request asked for. Currently, NASA is developing a new human lunar lander as part of its Artemis program, an initiative to send the first woman and first person of color to the Moon. Previously, Congress showed its reluctance to give NASA the money it requested for the lander. For 2021, appropriators only provided $850 million of the requested $3.4 billion for the lander.

McGruber writes: Retired NASA Astronaut Scott Kelly just announced that he was returning a medal awarded to him by Russia. A translation of his announcement, which Mr Kelly made in Russian:

The first person to have his failing heart replaced with that of a genetically altered pig in a groundbreaking operation died Tuesday afternoon at the University of Maryland Medical Center, two months after the transplant surgery. From a report: David Bennett Sr., who lived in Maryland, was 57. He had severe heart disease, and had agreed to receive the experimental pig's heart after he was rejected from several waiting lists to receive a human heart. It was unclear whether his body had rejected the foreign organ. "There was no obvious cause identified at the time of his death," a hospital spokeswoman told the newspaper. The report adds: Hospital officials said they could not comment further on the cause of death, because his physicians had yet to conduct a thorough examination. They plan to publish the results in a peer-reviewed medical journal. Dr. Bartley Griffith, the surgeon who performed the transplant, said the hospital's staff was "devastated" by the loss of Mr. Bennett. "He proved to be a brave and noble patient who fought all the way to the end," Dr. Griffith said. "Mr. Bennett became known by millions of people around the world for his courage and steadfast will to live."

An experimental new type of cancer treatment has yielded some impressive results in mice: the eradication of advanced-stage ovarian and colorectal cancer in the animals as little as six days. ScienceAlert reports: The new therapy has only been tested in mice so far, so let's not get too excited just yet. However, the early signs are promising, and human clinical trials could be underway by the end of the year. The treatment involves tiny 'drug factory' beads that are implanted into the body and deliver a continuous, high dose of interleukin-2 (IL2) -- a natural compound that enlists white blood cells in the fight against cancer.

"We just administer once, but the drug factories keep making the dose every day, where it's needed until the cancer is eliminated," says bioengineer Omid Veiseh from Rice University in Texas. "Once we determined the correct dose -- how many factories we needed -- we were able to eradicate tumors in 100 percent of animals with ovarian cancer and in seven of eight animals with colorectal cancer." The research has been published in the journal Science Advances.

An anonymous reader quotes a report from Motherboard: People are review-bombing a hospital in India with one-star reviews after a doctor tweeted a video of himself during a procedure with an unconscious patient. The anesthesiologist, who goes by Dr. Shreeveera on Twitter and his YouTube channel, filmed himself supposedly in an active operating room where he had just anesthetized a patient and was preparing for an invasive procedure to remove a gallbladder. He claimed to be defending himself against people claiming he's not a real doctor, because they disagree with his passion for the "console wars." "Console wars" is shorthand for the decades-long argument between gamers about which platform -- Xbox, Playstation, Nintendo devices, PC gaming, and so on -- is the best.

Shreeveera posted the video to Twitter, writing, "Here I am after inducing anaesthesia, intubating & putting a patient on controlled mechanical ventilation for a Laparoscopic Cholecystectomy case in OR. Slandering my identity, profession coz you Xbots can't Argue FACTS!" according to gaming news outlet Dextero. He added, "SAVING LIVES- My Job. CONSOLE WARS- My Hobby." He was allegedly trying to defend himself from accusations that he wasn't a real doctor. Dextero, which viewed the video before Shreeveera locked his Twitter account, says that he pans around an operating room holding up the phone to record himself, showing the patient on the operating table.

Shreeveera posted an unlisted apology video on YouTube on Monday, saying that he's received a lot of backlash and racist harassment because of his video. He says he regrets posting the video and acknowledges that his obsession with console wars is childish, but also tries defending himself and his hobby. "I'm a human being guys, I make mistakes, please let's move on ahead," he said. "I do not hate anyone on a personal level. If I do not like the console they're playing, I just make points regarding what that console is giving you... this is just a hobby of mine." Judging from his YouTube channel, Shreeveera is clearly a PlayStation fan and an Xbox hater.

People who have a rosy outlook on the world may live healthier, longer lives because they have fewer stressful events to cope with, new research suggests. From a report: Scientists found that while optimists reacted to, and recovered from, stressful situations in much the same way as pessimists, the optimists fared better emotionally because they had fewer stressful events in their daily lives. How optimists minimise their dose of stress is unclear, but the researchers believe they either avoid arguments, lost keys, traffic jams and other irritations, or simply fail to perceive them as stressful in the first place. Previous studies have found evidence that optimists live longer and healthier lives, but researchers do not fully understand why having a glass-half-full attitude might contribute to healthy ageing. "Given prior work linking optimism to longevity, healthy ageing, and lower risks of major diseases, it seemed like a logical next step to study whether optimism might protect against the effects of stress among older adults," said Dr Lewina Lee, a clinical psychologist at the Veterans Affairs Boston Healthcare System and assistant professor of psychiatry at Boston University.

An anonymous reader quotes a report from Scientific American: New research, published in the journal Physiological Entomology, suggests that the palm-sized Joro spider, which swarmed North Georgia by the millions last September, has a special resilience to the cold. This has led scientists to suggest that the 3-inch (7.6 centimeters) bright-yellow-striped spiders -- whose hatchlings disperse by fashioning web parachutes to fly as far as 100 miles (161 kilometers) -- could soon dominate the Eastern Seaboard. Since the spider hitchhiked its way to the northeast of Atlanta, Georgia, inside a shipping container in 2014, its numbers and range have expanded steadily across Georgia, culminating in an astonishing population boom last year that saw millions of the arachnids drape porches, power lines, mailboxes and vegetable patches across more than 25 state counties with webs as thick as 10 feet (3 meters) deep, Live Science previously reported.

Common to China, Taiwan, Japan and Korea, the Joro spider is part of a group of spiders known as "orb weavers" because of their highly symmetrical, circular webs. The spider gets its name from Jorgumo, a Japanese spirit, or Ykai, that is said to disguise itself as a beautiful woman to prey upon gullible men. True to its mythical reputation, the Joro spider is stunning to look at, with a large, round, jet-black body cut across with bright yellow stripes, and flecked on its underside with intense red markings. But despite its threatening appearance and its fearsome standing in folklore, the Joro spider's bite is rarely strong enough to break through the skin, and its venom poses no threat to humans, dogs or cats unless they are allergic. That's perhaps good news, as the spiders are destined to spread far and wide across the continental U.S., researchers say.

The scientists came to this conclusion after comparing the Joro spider to a close cousin, the golden silk spider, which migrated from tropical climates 160 years ago to establish an eight-legged foothold in the southern United States. By tracking the spiders' locations in the wild and monitoring their vitals as they subjected caught specimens to freezing temperatures, the researchers found that the Joro spider has about double the metabolic rate of its cousin, along with a 77% higher heart rate and a much better survival rate in cold temperatures. Additionally, Joro spiders exist in most parts of their native Japan -- warm and cold -- which has a very similar climate to the U.S. and sits across roughly the same latitude. [...] While most invasive species tend to destabilize the ecosystems they colonize, entomologists are so far optimistic that the Joro spider could actually be beneficial, especially in Georgia where, instead of lovesick men, they kill off mosquitos, biting flies and another invasive species -- the brown marmorated stink bug, which damages crops and has no natural predators. In fact, the researchers say that the Joro is much more likely to be a nuisance than a danger, and that it should be left to its own devices.

Researchers have now harnessed the power of artificial intelligence to infer how pigs are feeling on the basis of their grunts. The Guardian reports: Scientists believe that the AI pig translator -- which turns oinks, snuffles, grunts and squeals into emotions -- could be used to automatically monitor animal wellbeing and pave the way for better livestock treatment on farms and elsewhere. "We have trained the algorithm to decode pig grunts," said Dr Elodie Briefer, an expert in animal communication who co-led the work at the University of Copenhagen. "Now we need someone who wants to develop the algorithm into an app that farmers can use to improve the welfare of their animals."

Working with an international team of colleagues, Briefer trained a neural network to learn whether pigs were experiencing positive emotions, such as happiness or excitement, or negative emotions, such as fear and distress, using audio recordings and behavioral data from pigs in different situations, from birth through to death. Writing in the journal Scientific Reports, the researchers describe how they used the AI to analyze the acoustic signatures of 7,414 pig calls recorded from more than 400 animals. While most of the recordings came from farms and other commercial settings, others came from experimental enclosures where pigs were given toys, food and unfamiliar objects to nose around and explore.

The scientists used the algorithm to distinguish calls linked to positive emotions from those linked to negative emotions. The different noises represented emotions across the spectrum and reflected positive situations, such as huddling with littermates, suckling their mothers, running about and being reunited with the family, to negative situations ranging from piglet fights, crushing, castration and waiting in the abattoir. The researchers found that there were more high-pitched squeals in negative situations. Meanwhile, low-pitched grunts and barks were heard across the board, regardless of their predicament. Short grunts, however, were generally a good sign of porcine contentment.

Over 170 million U.S.-born people who were adults in 2015 were exposed to harmful levels of lead as children, a new study estimates. The Associated Press reports: Researchers used blood-lead level, census and leaded gasoline consumption data to examine how widespread early childhood lead exposure was in the country between 1940 and 2015. In a paper published in the Proceedings of the National Academy of Sciences on Monday, they estimated that half the U.S. adult population in 2015 had been exposed to lead levels surpassing five micrograms per deciliter -- the Centers for Disease Control and Prevention threshold for harmful lead exposure at the time.

The scientists from Florida State University and Duke University also found that 90% of children born in the U.S. between 1950 and 1981 had blood-lead levels higher than the CDC threshold. And the researchers found significant impact on cognitive development: on average, early childhood exposure to lead resulted in a 2.6-point drop in IQ. The researchers only examined lead exposure caused by leaded gasoline, the dominant form of exposure from the 1940s to the late 1980s, according to data from the U.S. Geological Survey. Leaded gasoline for on-road vehicles was phased out starting in the 1970s, then finally banned in 1996.

During at least the first few months following a coronavirus infection, even mild cases of Covid-19 are associated with subtle tissue damage and accelerated losses in brain regions tied to the sense of smell, as well as a small loss in the brain's overall volume, a new British study finds. Having mild Covid is also associated with a cognitive function deficit. NBC: These are the striking findings of the new study led by University of Oxford investigators, one that leading Covid researchers consider particularly important because it is the first study of the disease's potential impact on the brain that is based on brain scans taken both before and after participants contracted the coronavirus. "This study design overcomes some of the major limitations of most brain-related studies of Covid-19 to date, which rely on analysis and interpretation at a single time point in people who had Covid-19," said Dr. Serena S. Spudich, a neurologist at the Yale University School of Medicine, who was not involved in the research.

The research, which was published Monday in Nature, also stands out because the lion's share of its participants apparently had mild Covid -- by far, the most common outcome of coronavirus infections. Most of the brain-related studies in this field have focused on those with moderate to severe Covid. Gwenaelle Douaud, an associate professor at the Nuffield Department of Clinical Neurosciences at Oxford and the paper's lead author, said that the excess loss of brain volume she and her colleagues observed in brain scans of hundreds of British individuals is equivalent to at least one extra year of normal aging. "It is brain damage, but it is possible that it is reversible," she said. "But it is still relatively scary because it was in mildly infected people."

"Every day, several petabytes of data are generated on the internet," says Kasra Tabatabaei, a researcher at the Beckman Institute for Advanced Science and Technology. "Only one gram of DNA would be sufficient to store that data."

So the Institute is now announcing the results of a project Tabatabaei worked on "to transform the double helix into a robust, sustainable data storage platform." CNET reports: Tabatabaei is the co-author of a new study, published in last month's edition of the journal Nano Letters... Essentially, the study team is the first to artificially extend the DNA alphabet, which could allow for massive storage capacities and accommodate a pretty extreme level of digital data.... DNA encodes genetic information with four molecules called nucleotides. There's adenine, guanine, cytosine and thymine, or A, G, C and T. In a sense, DNA has a four-letter alphabet, and different letter combinations represent different bits of data....

But what if we had a longer alphabet? Presumably, that'd give us a much deeper capacity. Following this line of thought, the team behind the new study artificially added seven new letters to the DNA repertoire.... "Instead of converting zeroes and ones to A, G, C and T, we can convert zeroes and ones to A, G, C, T and the seven new letters in the storage alphabet."
One of the study's co-principal investigators said their work "provides an exciting proof-of-principle demonstration of extending macromolecular data storage to non-natural chemistries, which hold the potential to drastically increase storage density in non-traditional storage media."

Two new studies involving tens of thousands of British men and women "found that, most of the time, people who ran and rode vigorously had larger brain volumes and lower risks for dementia than their less active peers," reports the New York Times. (Alternate URL here.)

"But if people exercised in areas with even moderate levels of air pollution, the expected brain improvements from exercise almost disappeared...." [F]or the first of the new studies, published in January in Neurology, researchers at the University of Arizona and University of Southern California pulled records for 8,600 middle-aged adults enrolled in the UK Biobank. A huge trove of health and lifestyle records, the Biobank holds information on about more than 500,000 British adults, such as their ages, home locations, socioeconomic status, genomes and extensive health data. Some of the participants also completed brain scans and wore activity monitors for a week to track their exercise habits.

The researchers focused on those who had worn a monitor, had a brain scan and, according to their trackers, often exercised vigorously, such as by running, which meant they breathed heavily during workouts. The heavier you breathe, the more air pollutants you draw in. The researchers also included some people who never worked out vigorously, for comparison. Using established air quality models, they then estimated air pollution levels where the people lived and, finally, compared everyone's brain scans.

As expected, vigorous exercise was linked, in general, to sturdy brain health. Men and women who lived and presumably worked out in areas with little air pollution showed relatively large amounts of gray matter and low incidence of white matter lesions, compared to people who never exercised hard. And the more they exercised, the better their brains tended to look. But any beneficial associations almost disappeared when exercisers lived in areas with even moderate air pollution. (Levels in this study were mostly within the bounds considered acceptable for health by European and American air quality standards.) Their gray matter volume was smaller and white matter lesions more numerous than among people living and exercising away from pollution, even if their workouts were similar.

Extending these findings in a second, follow-up study published this month in Medicine & Science in Sports & Exercise, the same scientists repeated aspects of this experiment with another 35,562 older UK Biobank participants, comparing people's exercise habits, local pollution levels and diagnoses of dementia, if any. The data showed the more people exercised, the less likely they were to develop dementia over time — provided their local air was clear. When it was moderately polluted, though, they had an increased long-term risk of dementia, whether they exercised or not.
The Times also got this assessment of the studies from pollution researcher Pamela Lein, a professor of neurotoxicity at the University of California, Davis.

"The observation that air pollution negates the well-established beneficial effects of exercise on brain health is alarming and increases the urgency for developing more-effective regulatory policies" related to air quality.

"In a galaxy far, far away, two giant black holes appear to be circling each other like fighters in a galactic boxing ring," reports USA Today.

"Gravity is causing this death spiral, which will result in a collision and formation of a single black hole, a massive event that will send ripples through space and time." The collision itself happened eons ago — the two black holes are located about 9 billion light years from Earth. Scientists won't be able to document it for 10,000 years. Even so, there are imperceptible gravitational waves generated before the collision that are hitting us right now. These waves from the black holes' activity will increase, but will not affect Earth. However, they could help increase our understanding of how our universe has evolved.

Such supermassive black holes "are the most powerful and energetic objects in the universe and they have an enormous effect on the evolution of galaxies and stars," Tony Readhead, an astronomy professor at the California Institute of Technology, told USA TODAY. He is the co-author of the report by Caltech astronomers who detail the discovery in The Astrophysical Journal Letters, a peer-reviewed scientific journal. "If we want to understand the evolution of our universe we need to understand these objects," Readhead said....

Each of the black holes identified in this study has a mass amounting to hundreds of millions of times more than that of our sun, the researchers say. It took about 100 million years for the two objects to converge on their orbit, which has them at a distance of about 50 times that separating our sun and Pluto, NASA said. The two black holes are more than 99% of the way toward colliding, the agency said....

This is only the second pair of orbiting black holes identified by scientists, the researchers say. Space-time undulations from gravitational waves made by two colliding black holes 1.3 billion light-years away were recorded in 2015 by the National Science Foundation's Laser Interferometer Gravitational-Wave Observatory.