The U.S. government recently gave California approval to release millions of genetically engineered mosquitoes bred by British biotech company Oxitec, reports the Los Angeles Times: Oxitec, a private company, says its genetically modified bugs could help save half the world's population from the invasive Aedes aegypti mosquito, which can spread diseases such as yellow fever, chikungunya and dengue to humans. Female offspring produced by these modified insects will die, according to Oxitec's plan, causing the population to collapse. "Precise. Environmentally sustainable. Non-toxic," the company says on its website of its product trademarked as the "Friendly" mosquito.

Scientists independent from the company and critical of the proposal say not so fast. They say unleashing the experimental creatures into nature has risks that haven't yet been fully studied, including possible harm to other species or unexpectedly making the local mosquito population harder to control....

Nathan Rose, Oxitec's head of regulatory affairs, noted that the company found its mosquito reduced the population in a Brazilian neighborhood by 95% in just 13 weeks. So far, Oxitec has released little of its data from that experiment or from a more recent release in the Florida Keys. It hasn't yet published any of those results in a peer-reviewed scientific journal — publications that scientists expect when evaluating a new drug or technology....

Among scientists' concerns is that releasing the genetically modified mosquitoes into neighborhoods could create hybrids that are hardier and more dangerous to humans than the state's current population.... An EPA spokesperson said regulators expected that mosquitoes with the corporate genes "would disappear from the environment within 10 generations of mosquitoes because they are not able to reproduce as successfully as local populations." To prove this, the agency has required Oxitec to monitor neighborhoods for mosquitoes that have DNA from its engineered insects until none have been found for at least 10 consecutive weeks.
One bioethicist at Harvard Medical School told the Times that California has never had a case where this breed of mosquitos had actually transmitted disease, and argued that America's Environmental Protection Agency was "not a modern enough regulatory structure for a very modern and complicated technology."

After the U.S. government's approval, the genetically-engineered mosquitors still face several more months of scientific evaluation from California's Department of Pesticide Regulation.

Thanks to long-time Slashdot reader schwit1 for sharing the link

The New York Times reports: Pristine slivers of the impactor that killed the dinosaurs have been discovered, said scientists studying a North Dakota site that is a time capsule of that calamitous day 66 million years ago... "If you're able to actually identify it, and we're on the road to doing that, then you can actually say, 'Amazing, we know what it was,'" Robert DePalma, a paleontologist spearheading the excavation of the site, said Wednesday during a talk at the NASA Goddard Space Flight Center in Greenbelt....

A New Yorker article in 2019 described the site in southwestern North Dakota, named Tanis, as a wonderland of fossils buried in the aftermath of the impact some 2,000 miles away. Many paleontologists were intrigued but uncertain about the scope of DePalma's claims; a research paper published that year by DePalma and his collaborators mostly described the geological setting of the site, which once lay along the banks of a river. When the object hit Earth, carving a crater about 100 miles wide and nearly 20 miles deep, molten rock splashed into the air and cooled into spherules of glass, one of the distinct calling cards of meteor impacts. In the 2019 paper, DePalma and his colleagues described how spherules raining down from the sky clogged the gills of paddlefish and sturgeon, suffocating them.

Usually the outsides of impact spherules have been mineralogically transformed by millions of years of chemical reactions with water. But at Tanis, some of them landed in tree resin, which provided a protective enclosure of amber, keeping them almost as pristine as the day they formed.... Finding amber-encased spherules, he said, was the equivalent of sending someone back in time to the day of the impact, "collecting a sample, bottling it up and preserving it for scientists right now...."

DePalma said there also appear to be some bubbles within some of the spherules. Because the spherules do not look to be cracked, it's possible that they could hold bits of air from 66 million years ago.
In 1998, UCLA geochemist Frank Kyte claimed he'd found a fragment of that meteor in a core sample drilled off Hawaii, the article points out, "but other scientists were skeptical that any bits of the meteor could have survived."

But now DePalma tells the Times that this North Dakota discovery "actually falls in line with what Frank Kyte was telling us years ago."

Slashdot reader sciencehabit quotes Science magazine: Tiny molecular machines make life possible. Spinning rotary motors generate the chemical fuel our cells need, miniature walkers carry nutrients, and minute construction crews build proteins. Now, chemists are getting in on the act by making even smaller and simpler versions of these biological machines.

In three studies, scientists report designing their own molecular pumps and rotary motors. The puny devices are not quite ready to make their real-world debut, but future versions could suck carbon dioxide from the air and harvest valuable metals from seawater. The new studies show it's possible to get teams of motors all working in the same direction and concentrate target chemicals in a confined space, a feat biology uses to sustain work.

"These are very important steps toward useful real-life molecular machines," says Ivan Aprahamian, a chemist at Dartmouth College who wasn't involved with the studies.

The French aerospace company Gama has raised 2 million euros to deploy a solar sail in space. The Guardian reports: Solar sails require no engines to move. Instead, they are pushed around by the pressure of sunlight. The angle of the sail determines the direction of motion. Gama plans to deploy a 73.3-sq-meter solar sail in a 550km-altitude orbit in October. It will be launched as an additional payload on a SpaceX rocket.

Gama hopes to demonstrate that solar sails can revolutionize access to deep space because they are cost-effective and scalable in size. After this year's deployment test, the company plans to launch a follow-up mission in 2024 to a higher orbit to demonstrate control and onboard navigation. In 2025, it hopes to emulate the Japanese and fly to Venus.

A possible galaxy that exists some 13.5 billion light-years from Earth has broken the record for farthest astronomical object ever seen. Live Science reports: That age places this collection of stars, now dubbed HD1, between a time of total darkness -- about 14 billion years ago the universe was a blank slate devoid of any stars or galaxies -- and one of just-burgeoning lights as clumps of dust and gas were growing into their cosmic destinies. [...] The researchers discovered HD1 in data collected over 1,200 hours of observation time using the Subaru Telescope, the VISTA Telescope, the U.K. Infrared Telescope and the Spitzer Space Telescope. They were particularly looking at redshift, a phenomenon in which light waves stretch out or become redder as an object moves away from the observer. In this case, the redshift suggested HD1 was extremely distant. The researchers found that the red wavelengths were the equivalent to a galaxy located 13.5 billion light-years away.

HD1 also seems to be growing at a feverish rate -- about 100 stars each year, or at least 10 times the rate predicted for starburst galaxies that are known to produce stars at an extraordinarily high pace. These stars were also more massive, brighter (in ultraviolet wavelengths) and hotter than younger stars, the researchers found. As such, HD1 could be home to the universe's very first stars, called Population III stars; if that identity is verified, this would be the first observation of this type of star, the researchers said. There's also the possibility that HD1 is a supermassive black hole with a mass of about 100 million times that of the sun. To figure out HD1's true identity, the researchers can look for X-rays, which are emitted as material gets devoured by the gravity of a black hole. "If HD1 is a black hole, we should see X-ray emission from it. If we do not find X-rays, the emission must originate from massive stars," [one of the researchers told Live Science].

An anonymous reader quotes a report from the Guardian: It's a sunny day on a city street as a green bus pulls up by the kerb. Onboard, a handful of passengers sit stony-faced as you step up to present your pass. But you cannot see your body -- only a floating pair of blue hands. It might sound like a bizarre dream, but the scenario is part of a virtual reality (VR) system designed to help people with agoraphobia -- those for whom certain environments, situations and interactions can cause intense fear and distress. Scientists say the approach enables participants to build confidence and ease their fears, helping them to undertake tasks in real life that they had previously avoided. The study also found those with more severe psychological problems benefited the most. "It leads to a real step-change in people's lives," said Prof Daniel Freeman, the lead researcher in the work, from the psychiatry department at the University of Oxford.

The VR experience begins in a virtual therapist's office before moving to scenarios such as opening the front door or being in a doctor's surgery, each with varying levels of difficulty. Participants are asked to complete certain tasks, such as asking for a cup of coffee, and are encouraged to make eye contact or move closer to other characters. Freeman said while the scenarios feel real, the computer-generated scenes allow participants to feel able to try something new or approach the situation differently. "There's a little bit of the conscious bit [of the brain] going: 'OK, it's OK, I know it's not real and therefore I can persist, try something new and do something differently,'" he said. "That enables people to apply it in the real world. Basically, if you get over something in VR, you will get over in the real world."

Writing in the Lancet Psychiatry journal, Freeman and colleagues report how they randomly allocated 174 patients with difficulties going outside and psychosis to use the "gameChange" VR technology alongside their usual care. Another 172 patients were allocated to receive their usual care alone. [...] The results show that six weeks after the trial began, those allocated to the VR therapy had a small but significant reduction in avoiding real-life situations because of agoraphobia, as well as less distress, compared with those who had only received their usual care. However, by six months there was no difference between the two groups. But further analysis revealed that those who had severe agoraphobia benefited most, and for these people the effect was sustained at six months. Such patients were able to complete, on average, two more activities than before -- such as going shopping or getting on a bus.

Nissan is working with NASA on a new type of battery for electric vehicles that promises to charge more quickly and be lighter yet safe, the Japanese automaker said Friday. CBS News reports: The all-solid-state battery will replace the lithium-ion battery now in use for a 2028 product launch and a pilot plant launch in 2024, according to Nissan. The battery would be stable enough to be used in pacemakers, Nissan said. When finished, it will be about half the size of the current battery and fully charge in 15 minutes instead of a few hours.

The collaboration with the U.S. space program, as well as the University of California San Diego, involves the testing of various materials, Corporate Vice President Kazuhiro Doi told reporters. "Both NASA and Nissan need the same kind of battery," he said. Nissan and NASA are using what's called the "original material informatics platform," a computerized database, to test various combinations to see what works best among hundreds of thousands of materials, Doi said. The goal is to avoid the use of expensive materials like rare metals needed for lithium-ion batteries.

The United States set a major renewable energy milestone last Tuesday: wind power was the second-highest source of electricity for the first time since the Energy Information Administration began gathering the data. From a report: As E&E reporter Ben Storrow noted and the EIA confirmed, wind turbines last Tuesday generated over 2,000 gigawatt-hours of electricity, edging out electricity generated by nuclear and coal (but still trailing behind natural gas). Last year, wind was the fourth-largest electricity source behind natural gas, coal, and nuclear, generating close to 380 terawatt-hours for the entire year, according to the EIA. For context, a terawatt is a thousand times bigger than a gigawatt.

Major milestone aside, wind energy in the US is still lagging behind one European country that recently broke a record of its own: Germany. Although the US has more wind capacity by sheer numbers -- it's a larger country with a larger population -- Germany is outpacing the US in terms of how much electricity it gets from wind. In February alone, windmills in Germany generated a record 20.6 terawatt-hours of wind energy, Rystad Energy reported Tuesday, which made up 45% of its total energy in February. In 2020 -- the most recent year the EIA has robust statistics for -- Germany got 24% of its electricity from wind, compared to 8% in the US.

Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic. Nature: According to Trish Greenhalgh, a primary-care health researcher at the University of Oxford, UK, the IPC GDG members were guided by their medical training and the dominant thinking in the medical field about how infectious respiratory diseases spread; this turned out to be flawed in the case of SARS-CoV-2 and could be inaccurate for other viruses as well. These biases led the group to discount relevant information -- from laboratory-based aerosol studies and outbreak reports, for instance. So the IPC GDG concluded that airborne transmission was rare or unlikely outside a small set of aerosol-generating medical procedures, such as inserting a breathing tube into a patient.

That viewpoint is clear in a commentary by members of the IPC GDG, including Schwaber, Sobsey and Fisher, published in August 20202. The authors dismissed research using air-flow modelling, case reports describing possible airborne transmission and summaries of evidence for airborne transmission, labelling such reports "opinion pieces." Instead, they concluded that "SARS-CoV-2 is not spread by the airborne route to any significant extent." In effect, the group failed to look at the whole picture that was emerging, says Greenhalgh. "You've got to explain all the data, not just the data that you've picked to support your view," and the airborne hypothesis is the best fit for all the data available, she says. One example she cites is the propensity for the virus to transmit in 'superspreader events,' in which numerous individuals are infected at a single gathering, often by a single person. "Nothing explains some of these superspreader events except aerosol spread," says Greenhalgh.

Throughout 2020, there was also mounting evidence that indoor spaces posed a much greater risk of infection than outdoor environments did. An analysis of reported outbreaks recorded up to the middle of August 2020 revealed that people were more than 18 times as likely to be infected indoors as outdoors3. If heavy droplets or dirty hands had been the main vehicles for transmitting the virus, such a strong discrepancy would not have been observed. Although the WHO played down the risk of airborne transmission, it did invite Li [a building environment engineer at the University of Hong Kong who suspected early on that SARS-CoV-2 was also airborne] to become a member of the IPC GDG after he spoke to the group in mid-2020. Had the organization not at least been open to his view that infections were caused by aerosols, especially at short range, "they would not have invited me there as they knew my standing," he says.

People could eventually be able to turn the clock back on the cell-ageing process by 30 years, according to researchers who have developed a technique for reprogramming skin cells to behave as if they are much younger. From a report: Research from the Babraham Institute, a life sciences research organisation in Cambridge, could lead to the development of techniques that will stave off the diseases of old age by restoring the function of older cells and reducing their biological age. In experiments simulating a skin wound, older cells were exposed to a concoction of chemicals that "reprogrammed" them to behave more like youthful cells and removed age-related changes.

This has been previously achieved, but the new work was completed in a much a shorter time frame -- 13 days compared with 50 -- and made the cells even younger. Dr Diljeet Gill, a researcher at the Babraham Institute, said: "Our understanding of ageing on a molecular level has progressed over the last decade, giving rise to techniques that allow researchers to measure age-related biological changes in human cells. We were able to apply this to our experiment to determine the extent of reprogramming our new method achieved. Our results represent a big step forward in our understanding of cell reprogramming."

Across three different animal models researchers have demonstrated how short bursts of ultrasound targeted at specific clusters of nerves in the liver can effectively lower insulin and glucose levels. New Atlas reports: Reporting in the journal Nature Biomedical Engineering, a team led by GE Research, including investigators from the Yale School of Medicine, UCLA, and the Feinstein Institutes for Medical Research, demonstrated a unique non-invasive ultrasound method designed to stimulate specific sensory nerves in the liver. The technology is called peripheral focused ultrasound stimulation (pFUS) and it allows highly targeted ultrasound pulses to be directed at specific tissue containing nerve endings. "We used this technique to explore stimulation of an area of the liver called the porta hepatis," the researchers explained in a Nature briefing. "This region contains the hepatoportal nerve plexus, which communicates information on glucose and nutrient status to the brain but has been difficult to study as its nerve structures are too small to separately stimulate with implanted electrodes."

The newly published study indicates short targeted bursts of pFUS at this area of the liver successfully reversed the onset of hyperglycaemia. The treatment was found to be effective in three separate animal models of diabetes: mice, rats and pigs. [...] The study found just three minutes of focused ultrasound each day was enough to maintain normal blood glucose levels in the diabetic animals. Studies in humans are currently underway to work out whether this method translates from animal studies. But there are other hurdles facing broad clinical deployment of the technique beyond simply proving it works. Current ultrasound tools used to perform this kind of pFUS technique require trained technicians. The researchers suggest the technology exists to simplify and automate these systems in a way that could be used by patients at home, but it will need to be developed before this treatment can be widely deployed.

Loren Grush writes via The Verge: Tomorrow morning, SpaceX is set to launch yet another crew of four to the International Space Station from Florida -- but unlike most of the company's passenger flights, this new crop of flyers won't include any current NASA astronauts. All four members of the crew are civilians, flying with a commercial aerospace company called Axiom Space. Their flight will mark the first time a completely private crew has visited the ISS. It's a new type of human spaceflight mission and one that comes with a hefty price tag for its participants. Three of the four flyers have each paid a reported $55 million for their seats on SpaceX's crew capsule, called the Crew Dragon. The trio of novice spacefarers includes Canadian investor Mark Pathy, American real estate investor Larry Connor, and former Israeli Air Force pilot Eytan Stibbe. The commander of the trip is a spaceflight veteran: Michael Lopez-Alegria, a former NASA astronaut who has flown four missions to space and now serves as a vice president of Axiom.

Their mission, called Ax-1, is the latest in an emerging trend of completely private astronaut flights to orbit. [...] Axiom -- which strives to create a fleet of commercial space stations -- has arranged for three additional private crew missions to the ISS, just like Ax-1, to gear up for the creation of its first station. The company's goal is to "make space more accessible to everyone." "This really does represent the first step where a bunch of individuals who want to do something meaningful in low Earth orbit -- that aren't members of a government -- are able to take this opportunity," Mike Suffredini, Axiom's CEO and the former program manager of the ISS at NASA, said during a press conference. Though, until costs come down, such individuals will need a fat wallet.

An anonymous reader quotes a report from Motherboard: An object from another star system crashed into Earth in 2014, the United States Space Command (USSC) confirmed in a newly-released memo. The meteor ignited in a fireball in the skies near Papua New Guinea, the memo states, and scientists believe it possibly sprinkled interstellar debris into the South Pacific Ocean. The confirmation backs up the breakthrough discovery of the first interstellar meteor -- and, retroactively, the first known interstellar object of any kind to reach our solar system -- which was initially flagged by a pair of Harvard University researchers in a study posted on the preprint server arXiv in 2019.

Amir Siraj, a student pursuing astrophysics at Harvard who led the research, said the study has been awaiting peer review and publication for years, but has been hamstrung by the odd circumstances that arose from the sheer novelty of the find and roadblocks put up by the involvement of information classified by the U.S. government. The discovery of the meteor, which measured just a few feet wide, follows recent detections of two other interstellar objects in our solar system, known as 'Oumuamua and Comet Borisov, that were much larger and did not come into close contact with Earth.

"I get a kick out of just thinking about the fact that we have interstellar material that was delivered to Earth, and we know where it is," said Siraj, who is Director of Interstellar Object Studies at Harvard's Galileo Project, in a call. "One thing that I'm going to be checking -- and I'm already talking to people about -- is whether it is possible to search the ocean floor off the coast of Papua New Guinea and see if we can get any fragments." Siraj acknowledged that the odds of such a find are low, because any remnants of the exploded fireball probably landed in tiny amounts across a disparate region of the ocean, making it tricky to track them down. "It would be a big undertaking, but we're going to look at it in extreme depth because the possibility of getting the first piece of interstellar material is exciting enough to check this very thoroughly and talk to all the world experts on ocean expeditions to recover meteorites," he noted. "Siraj called the multi-year process a 'whole saga' as they navigated a bureaucratic labyrinth that wound its way though Los Alamos National Laboratory, NASA, and other governmental arms, before ultimately landing at the desk of Joel Mozer, Chief Scientist of Space Operations Command at the U.S. Space Force service component of USSC," adds Motherboard.

Mozer confirmed that the object indicated "an interstellar trajectory," which was first brought to Siraj's attention last week via a tweet from a NASA scientist. He's now "renewing the effort to get the original discovery published so that the scientific community can follow-up with more targeted research into the implications of the find," the report says.

Despite the availability of life-saving COVID-19 vaccines, so many people died in the second year of the pandemic in the U.S. that the nation's life expectancy dropped for a second year in a row last year, according to a new analysis. NPR reports: The analysis of provisional government statistics found U.S. life expectancy fell by just under a half a year in 2021, adding to a dramatic plummet in life expectancy that occurred in 2020. Public health experts had hoped the vaccines would prevent another drop the following year. "The finding that instead we had a horrible loss of life in 2021 that actually drove the life expectancy even lower than it was in 2020 is very disturbing," says Dr. Steven Woolf, a professor of population health and health equity at Virginia Commonwealth University, who help conduct the analysis. "It speaks to an extensive loss of life during 2021."

Many of the deaths occurred in people in the prime of their lives, Woolf says, and drove the overall U.S. life expectancy to fall to 76.6 years -- the lowest in at least 25 years. "The motivation for this study was to determine whether the horrible drop in life expectancy that we documented in 2020 resolved or rebounded in 2021 or whether there was a continued decline. Unfortunately, we did not find good news," Woolf told NPR in an interview.

After 10 years of careful analysis and scrutiny, scientists of the CDF collaboration at the U.S. Department of Energy's Fermi National Accelerator Laboratory announced today that they have achieved the most precise measurement to date of the mass of the W boson, one of nature's force-carrying particles. Phys.Org reports: Using data collected by the Collider Detector at Fermilab, or CDF, scientists have now determined the particle's mass with a precision of 0.01% -- twice as precise as the previous best measurement. It corresponds to measuring the weight of an 800-pound gorilla to 1.5 ounces. The new precision measurement, published in the journal Science, allows scientists to test the standard model of particle physics, the theoretical framework that describes nature at its most fundamental level. The result: The new mass value shows tension with the value scientists obtain using experimental and theoretical inputs in the context of the standard model. If confirmed, this measurement suggests the potential need for improvements to the standard model calculation or extensions to the model.

A British startup pioneering a new approach to fusion energy has successfully combined atomic nuclei, in what the UK regulator described as an important step in the decades-long effort to generate electricity from the reaction that powers the sun. From a report: Oxford-based First Light Fusion, which has been developing an approach called projectile fusion since 2011, said it had produced energy in the form of neutrons by forcing deuterium isotopes to fuse, validating years of research. While other fusion experiments have generated more power for longer, either by using "tokamak" machines or high-powered lasers, First Light says its approach, which involves firing a projectile at a target containing the fuel, could offer a faster route to commercial fusion power. "The value of this [result] is that it offers potentially a much cheaper, a much easier path to power production," said chief executive Nicholas Hawker.

To achieve fusion, First Light used a hyper-velocity gas gun to launch a projectile at a speed of 6.5km per second -- about 10 times faster than a rifle bullet -- at a tiny target designed to amplify the energy of the impact and force the deuterium fuel to fuse. The design of the target -- a clear cube, a little over a centimetre wide, enclosing two spherical fuel capsules -- is the key technology and is closely guarded by the company. "It is the ultimate espresso capsule," Hawker told the Financial Times last year. First Light, which is backed by China's Tencent, hopes to manufacture and sell the targets to future power plants -- built to its design -- which would need to vaporise one every 30 seconds to generate continual power. Further reading: So How Close Are We Now to Nuclear Fusion Energy? (August 2021).

An anonymous reader shares a report: Bad news for everyone who loved watching Bill Nye the Science Guy during middle school science class: your fave is problematic. This week, Coca-Cola, one of the world's biggest plastic polluters, teamed up with TV's favorite scientist for a campaign to create a "world without waste," a joke of a corporate greenwashing campaign. In a video innocuously titled "The Coca-Cola Company and Bill Nye Demystify Recycling," an animated version of Nye -- with a head made out of a plastic bottle and his signature bow tie fashioned from a Coke label -- walks viewers through the ways "the good people at the Coca-Cola company are dedicating themselves to addressing our global plastic waste problem." Coke, Nye explains, wants to use predominantly recycled materials to create bottles for its beverages; he then describes the process of recycling a plastic bottle, from a user throwing it into a recycling bin to being sorted and shredded into new material.

"If we can recover and recycle plastic, we can not only keep it from becoming trash, but we can use that plastic again and again -- it's an amazing material," quips Shill Nye the Plastic Guy. "What's more, when we use recycled material, we also reduce our carbon footprint. What's not to love?" What's not, indeed! The video is, on the surface, an accurate depiction of the process of recycling a beverage bottle. The problem lies in what recycling can actually do. Nye paints a rosy picture in the video of plastic Coke bottles being recycled "again and again" -- but if everything worked like he's said, we wouldn't be facing plastic pollution that has grown fourfold over the past few decades. Thanks to concerted lobbying efforts, the public has been led to believe that recycling is the cure for our disastrous plastic addiction. What it does in actuality is place the burden of responsibility on the consumer and allow companies like Coca-Cola to get away with no repercussions for their waste.

An anonymous reader quotes a report from the Guardian: Buried in forest litter or sprouting from trees, fungi might give the impression of being silent and relatively self-contained organisms, but a new study suggests they may be champignon communicators. Mathematical analysis of the electrical signals fungi seemingly send to one another has identified patterns that bear a striking structural similarity to human speech. Previous research has suggested that fungi conduct electrical impulses through long, underground filamentous structures called hyphae -- similar to how nerve cells transmit information in humans. It has even shown that the firing rate of these impulses increases when the hyphae of wood-digesting fungi come into contact with wooden blocks, raising the possibility that fungi use this electrical "language" to share information about food or injury with distant parts of themselves, or with hyphae-connected partners such as trees. But do these trains of electrical activity have anything in common with human language?

To investigate, Prof Andrew Adamatzky at the University of the West of England's unconventional computing laboratory in Bristol analyzed the patterns of electrical spikes generated by four species of fungi -- enoki, split gill, ghost and caterpillar fungi. He did this by inserting tiny microelectrodes into substrates colonized by their patchwork of hyphae threads, their mycelia. The research, published in Royal Society Open Science, found that these spikes often clustered into trains of activity, resembling vocabularies of up to 50 words, and that the distribution of these "fungal word lengths" closely matched those of human languages.

Split gills -- which grow on decaying wood, and whose fruiting bodies resemble undulating waves of tightly packed coral -- generated the most complex "sentences" of all. The most likely reasons for these waves of electrical activity are to maintain the fungi's integrity -- analogous to wolves howling to maintain the integrity of the pack -- or to report newly discovered sources of attractants and repellants to other parts of their mycelia, Adamatzky suggested. "There is also another option -- they are saying nothing," he said. "Propagating mycelium tips are electrically charged, and, therefore, when the charged tips pass in a pair of differential electrodes, a spike in the potential difference is recorded." Whatever these "spiking events" represent, they do not appear to be random, he added.

schwit1 shares a report from SpaceNews: In the largest commercial launch deal ever, Amazon is purchasing up to 83 launches from Arianespace, Blue Origin and United Launch Alliance to deploy most of its 3,236-satellite Project Kuiper broadband megaconstellation, contracts worth several billion dollars. Amazon announced April 5 the agreements to launch an unspecified number of satellites on Ariane 6, New Glenn and Vulcan Centaur rockets over five years. The launches are in addition to nine Atlas 5 launches it purchased from ULA a year ago. Amazon did not disclose financial terms but said it is spending billions of dollars on these contracts as part of the constellation's $10 billion overall cost.

Amazon is buying 38 Vulcan launches from ULA. The agreement includes additional investments in launch infrastructure to support a higher flight rate, such as a dedicated launch platform for Vulcan launches of Kuiper satellites. ULA will make its own investments to support processing two launch vehicles in parallel. "With a total of 47 launches between our Atlas and Vulcan vehicles, we are proud to launch the majority of this important constellation," Tory Bruno, chief executive of ULA, said in a company statement. "Amazon's investments in launch infrastructure and capability upgrades will benefit both commercial and government customers." The Arianespace deal includes 18 Ariane 6 launches, a contract that Stephane Israel, chief executive of Arianespace, described in a statement as the largest contract in his company's history. Blue Origin is selling 12 New Glenn launches with an option for 15 more. Notably absent is SpaceX, which in addition to its Falcon and Future Starship vehicles is developing its Starlink broadband constellation that will compete with Kuiper.

An anonymous reader quotes a report from the Guardian: Scientists have developed a blood test that can predict whether someone is at high risk of a heart attack, stroke, heart failure or dying from one of these conditions within the next four years. The test, which relies of measurements of proteins in the blood, has roughly twice the accuracy of existing risk scores. It could enable doctors to determine whether patients' existing medications are working or whether they need additional drugs to reduce their risk. It could also be used to hasten the development of new cardiovascular drugs by providing a faster means of assessing whether drug candidates are working during clinical trials. The test is already being used in four healthcare systems within the US and [...] it could be introduced to the UK in the near future.

[Researchers] used machine learning to analyze 5,000 proteins in blood plasma samples from 22,849 people and identify a signature of 27 proteins that could predict the four-year likelihood of heart attack, stroke, heart failure or death. When validated in 11,609 individuals, they found their model was roughly twice as good as existing risk scores, which use a person's age, sex, race, medical history, cholesterol and blood pressure to assess their likelihood of having a cardiovascular event. The results were published in Science Translational Medicine. Importantly, the test can also accurately assess risk in people who have previously had a heart attack or stroke, or have additional illnesses, and are taking drugs to reduce their risk, which is where existing risk prediction scores tend to fall down.